Development of external-stimuli-responsive nanomaterials and evaluation of their compatibility with living cells

• Project/Area Number: 26390020
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Nanomaterials chemistry
• Research Institution: Kumamoto University
• Principal Investigator: Kuwahara Yutaka 熊本大学, 大学院先端科学研究部(工), 助教 (60347002)
• Co-Investigator(Kenkyū-buntansha): 栗原 清二 熊本大学, 大学院先端科学研究部(工), 教授 (50225265) ; 山口 佳宏 熊本大学, 環境安全センター, 准教授 (10363524)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 光応答性材料 / 光応答性分子 / アゾベンゼン / ナノシート / 液晶 / 生体膜 / ナノ材料 / 抗菌機能

Outline of Final Research Achievements

We have developed photo-responsive small materials by utilizing external (photo)-stimuli-responsive molecules. The photo-responsive molecules were designed and synthesized under considering intermolecular interaction to organized molecules like liquid crystals and lipids. Under light irradiation, the photo-responsive materials modified by the photo-responsive molecules were able to induce partially disorganization of the aligned molecules. We have also evaluated inhibitory effect on cell multiplication by the photo-responsive materials under light irradiation.

Research Products

• [Journal Article] Photo-responsive traveling of small-particles modified with azobenzene groups as molecular motors in a liquid crystal (2016)
  • Author(s): Yutaka Kuwahara, Takahiro Oda, Sunnam Kim, Tomonari Ogata, Seiji Kurihara
  • Journal Title: Materials Letters Volume: 181 Pages: 257-260
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] Remote control of small particles modified with azobenzene derivatives by light irradiation (2016)
  • Author(s): Yutaka Kuwahara, Yoshihiro Yamaguchi, Seiji Kurihara
  • Organizer: The Applied Nanotechnology and Nanoscience International Conference
  • Place of Presentation: Barcelina, Spain
  • Int'l Joint Research
• [Presentation] Optical manipulation of small machines modified with azobenzene groups on a nematic liquid crystal film (2016)
  • Author(s): Yutaka Kuwahara, Takahiro Oda, Su Ma, Ryo Izumi, Sunnam Kim, Tomonari Ogata, Seiji Kurihara
  • Organizer: the 9th Asian and Oceanian Photochemistry Conference
  • Place of Presentation: Singapore
  • Int'l Joint Research
• [Presentation] Light-induced Phase Transition of Lyotropic Liquid Crystals and Motion Behavior of Micron Objects via Photochemical Azobenzene Molecules (2015)
  • Author(s): Su Ma, Yutaka Kuwahara, Tomonari Ogata, Sunnam Kim, Seiji Kurihara
  • Organizer: The 2015 International Conference on Material Science and Application (ICMSA 2015)
  • Place of Presentation: Suzhou, China
  • Year and Date: 2015-06-13
  • Int'l Joint Research