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Development of self-aligned nano-carbon biosensors using glycan for the highly pathogenic avian influenza virus

Research Project

Project/Area Number 26390030
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Nanomaterials engineering
Research InstitutionChubu University

Principal Investigator

KAWAHARA Toshio  中部大学, 工学部, 教授 (80437350)

Co-Investigator(Kenkyū-buntansha) 鈴木 康夫  中部大学, 生命健康科学部, 客員教授 (00046278)
Co-Investigator(Renkei-kenkyūsha) MAEHASHI Kenzo  東京農工大学, 大学院・工学研究院, 教授 (40229323)
OKAMOTO Kazumasa  北海道大学, 大学院・工学研究院, 助教 (10437353)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsナノカーボン応用 / バイオセンサー / ナノカーボン成長制御 / 自己組織化成長 / 電気伝導率制御 / 糖鎖の評価・最適化 / インフルエンザ感染性
Outline of Final Research Achievements

We have developed a self-alignment process for nano-carbon field effect transistors (FETs) using a carbon nanowall (CNW). Higher growth temperature enlarges the grain size in CNWs, and this results in a decrease in carrier scattering at the grain boundary. Using the low temperature buffer, we can improve the electric properties of channels. We also discussed about the plasma processes to improve the device properties of CNW-FETs. And we measured the pH dependence of the device properties. The binding molecules are known to be the key components for bio-sensors. We estimated the size of detection molecules of glycan for influenza viruses using atomic force microscopy. The typical molecule size is around 1 nm, and this may be suitable for electronic detection using a FET structure. We have also checked the selectivity of the graphene bio sensor. Furthermore, we have also evaluated the specific binding properties for the wild type of influenza virus in Egypt, Indonesia, and so forth.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (32 results)

All 2017 2016 2015 2014

All Journal Article (9 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 9 results,  Open Access: 3 results,  Acknowledgement Compliant: 3 results) Presentation (23 results) (of which Int'l Joint Research: 5 results,  Invited: 3 results)

  • [Journal Article] Synthesis of MoS2 ribbons and their branched structures by chemical vapor deposition in sulfur enriched environment2017

    • Author(s)
      Rakesh D. Mahyavanshi, Golap Kalita, Kamal P. Sharma, Masuharu Kondo, Takeshita Dewa, Toshio Kawahara, Masaki Tanemura
    • Journal Title

      Appl. Surf. Sci.

      Volume: 409 Pages: 396-402

    • DOI

      10.1016/j.apsusc.2017.03.074

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Development of Nano-Carbon Biosensors Using Glycan for Host Range Detection of Influenza Virus2016

    • Author(s)
      Toshio Kawahara, Hiroaki Hiramatsu, Yasuo Suzuki, Shin-ichi Nakakita, Yasuhide Ohno, Kenzo Maehashi, Kazuhiko Matsumoto, Kazumasa Okamoto, Teruaki Matsuba, Risa Utsunomiya
    • Journal Title

      Condens. Matter

      Volume: 1 Issue: 1 Pages: 7-7

    • DOI

      10.3390/condmat1010007

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Plasma process for the improvements of device characteristics for self-aligned nano-carbon FETs2016

    • Author(s)
      Toshio Kawahara, Singh R. Kumar, Yasuhide Ohno, Kenzo Maehashi, Kazuhiko Matsumoto, Kazumasa Okamoto, Risa Utsunomiya, Teruaki Matsuba
    • Journal Title

      Proc. of 38th International Symposium on Dry Process

      Volume: - Pages: 51-52

    • NAID

      130005175701

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CuNi binary alloy catalyst for growth of nitrogen-doped graphene by low pressure chemical vapor deposition2016

    • Author(s)
      Remi Papon, Kamal P. Sharma, Rakesh D. Mahayavanshi, Subash Sharma, Riteshkumar Vishwakarma, Mohamad Saufi Rosmi, Toshio Kawahara, Joseph Cline, Golap Kalita, Masaki Tanemura
    • Journal Title

      Phys. Status Solidi Rapid Res. Lett.

      Volume: 10 Issue: 10 Pages: 749-752

    • DOI

      10.1002/pssr.201600298

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Noise Spectroscopy of Self-aligned Carbon Nanowalls2015

    • Author(s)
      T. Kawahara, Y. Ohno, K. Maehashi, K. Matsumoto, K. Okamoto, R. Utsunomiya, T. Matsuba
    • Journal Title

      IEEE Conf. Proc.: 2015 23rd Int. Conf. Noise and Fluctuations (ICNF)

      Volume: - Pages: 108-111

    • DOI

      10.1109/icnf.2015.7288600

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 直接成長グラフェンによる自己組織化デバイスプロセス開発-自己組織化プロセスのデバイス特性への影響2015

    • Author(s)
      河原敏男, 玉田敦子
    • Journal Title

      中部大学 総合工学研究所、総合工学

      Volume: 27 Pages: 28-35

    • NAID

      120006520397

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Carbon Nanowall Field Effect Transistors Using a Self-Aligned Growth Process2014

    • Author(s)
      T. Kawahara, S. Yamaguchi, Y. Ohno, K. Maehashi, K. Matsumoto, K. Okamoto, R. Utsunomiya, T. Matsuba
    • Journal Title

      e-Journal of Surface Science and Nanotechnology

      Volume: 12 Issue: 0 Pages: 225-229

    • DOI

      10.1380/ejssnt.2014.225

    • NAID

      130004438881

    • ISSN
      1348-0391
    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Raman spectral mapping of self-aligned carbon nanowalls2014

    • Author(s)
      Toshio Kawahara, Satarou Yamaguchi, Yasuhide Ohno, Kenzo Maehashi, Kazuhiko Matsumoto, Kazumasa Okamoto, Risa Utsunomiya, Teruaki Matsuba, Yuki Matsuoka, Masamichi Yoshimura
    • Journal Title

      Jpn. J. Appl. Phys.

      Volume: 53 Issue: 5S1 Pages: 05FD10-05FD10

    • DOI

      10.7567/jjap.53.05fd10

    • NAID

      210000143823

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] ナノカーボン超高感度センサーによる感染症との闘い2014

    • Author(s)
      河原敏男、玉田敦子
    • Journal Title

      アリーナ (風媒社)

      Volume: 17 Pages: 74-92

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] 納豆のインフルエンザウイルス感染症予防効果の評価2017

    • Author(s)
      林京子, 田谷有紀, 西谷啓, 小林知世, 李貞範, 河原敏男, 林利光
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台国際センター (宮城県仙台市)
    • Year and Date
      2017-03-26
    • Related Report
      2016 Annual Research Report
  • [Presentation] ヒト感染性の即時鑑別のための糖鎖機能化グラフェンを用いたインフルエンザウイルスの検出2017

    • Author(s)
      川田拓哉, 小野尭生, 金井康, 大野恭秀, 前橋兼三, 井上恒一, 渡邊洋平, 河原敏男, 鈴木康夫, 中北愼一, 松本和彦
    • Organizer
      第64回応用物理学会春季学術講演会
    • Place of Presentation
      パシフィコ横浜 (神奈川県横浜市)
    • Year and Date
      2017-03-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] Comparison of Sugar Chains of Sialylglycopeptide and Sialyllactose for the Application of Influenza Bio Sensor2016

    • Author(s)
      Toshio Kawahara, Hiroaki Hiramatsu, Yuhsuke Ohmi, Yasuo Suzuki, Shin-ichi Nakakita, Yasuhide Ohno, Kenzo Maehashi, Kazuhiko Matsumoto
    • Organizer
      24th International Colloquium on Scanning Probe Microscopy (ICSPM24)
    • Place of Presentation
      HAWAII CONVENTION CENTER (USA, Honolulu)
    • Year and Date
      2016-12-14
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] カーボンナノウォールFETのためのプラズマプロセス2016

    • Author(s)
      河原敏男, Singh R. Kumar, 大野恭秀, 前橋兼三, 松本和彦, 岡本一将, 宇都宮里佐, 松葉晃明
    • Organizer
      第57回真空に関する連合講演会・第36回表面科学学術講演会
    • Place of Presentation
      名古屋国際会議場 (愛知県名古屋市)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] インフルエンザウイルス変異監視デバイス開発のための糖鎖分子の検討2016

    • Author(s)
      平松宏明, 河原敏男, 鈴木康夫, 中北愼一, 渡邊洋平, 大野恭秀, 前橋兼三, 小野暁生, 金井康, 松本和彦
    • Organizer
      日仏生物学会第185回例会
    • Place of Presentation
      東北大学学際科学フロンティア研究所 (宮城県仙台市)
    • Year and Date
      2016-11-26
    • Related Report
      2016 Annual Research Report
  • [Presentation] Plasma process for the improvements of device characteristics for self-aligned nano-carbon FETs2016

    • Author(s)
      Toshio Kawahara, Singh R. Kumar, Yasuhide Ohno, Kenzo Maehashi, Kazuhiko Matsumoto, Kazumasa Okamoto, Risa Utsunomiya, Teruaki Matsuba
    • Organizer
      38th International Symposium on Dry Process
    • Place of Presentation
      北海道大学 (北海道札幌市)
    • Year and Date
      2016-11-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Raman Spectroscopic Analysis of Carbon Nano-walls Grown on Low Temperature Buffer Layer2016

    • Author(s)
      Singh R. Kumar, Toshimasa Kawagiwa, Toshio Kawahara
    • Organizer
      第4回応用物理学会SC東海地区学術講演会
    • Place of Presentation
      名古屋大学 (愛知県名古屋市)
    • Year and Date
      2016-10-29
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Developments of the nano-carbon bio sensors using glycan for influenza virus2016

    • Author(s)
      Toshio Kawahara, Hiroaki Hiramatsu, Yasuo Suzuki, Shin-ichi Nakakita, Yasuhide Ohno, Kenzo Maehashi, Kazuhiko Matsumoto, Kazumasa Okamoto, Teruaki Matsuba, Risa Utsunomiya
    • Organizer
      13th International Conference on Atomically Controlled Surfaces, Interfaces and Nanostructures (ACSIN2016)
    • Place of Presentation
      Frascati National Laboratories (Rome, Italy)
    • Year and Date
      2016-10-14
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 糖鎖機能化グラフェンFET を用いた抗ウイルス薬効評価のためのノイラミニダーゼ反応計測2016

    • Author(s)
      鎌田果歩, 小野尭生, 金井康, 大野恭秀, 前橋兼三, 井上恒一, 渡邊洋平, 河原敏男, 鈴木康夫, 中北愼一, 松本和彦
    • Organizer
      第77回応用物理学会秋季学術講演会
    • Place of Presentation
      朱鷺メッセ (新潟県新潟市)
    • Year and Date
      2016-09-15
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] インフルエンザバイオセンサー開発のための糖鎖分子の検討2016

    • Author(s)
      河原敏男, 平松宏明, 鈴木康夫, 中北愼一, 渡邊洋平, 大野恭秀, 前橋兼三, 小野尭生, 金井康, 松本和彦
    • Organizer
      第77回応用物理学会秋季学術講演会
    • Place of Presentation
      朱鷺メッセ (新潟県新潟市)
    • Year and Date
      2016-09-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] 糖鎖機能化グラフェンFET を用いたノイラミニダーゼ反応計測2016

    • Author(s)
      鎌田果歩、小野尭生、金井康、大野恭秀、前橋兼三、井上恒一、渡邊洋平、河原敏男、鈴木康夫、中北愼一、松本和彦
    • Organizer
      第63回応用物理学会春季学術講演会
    • Place of Presentation
      東京工業大学大岡山キャンパス (東京都目黒区)
    • Year and Date
      2016-03-21
    • Related Report
      2015 Research-status Report
  • [Presentation] ウイルス検出のための糖鎖機能化グラフェンFET の修飾糖鎖の検討2016

    • Author(s)
      林亮太、小野尭生、金井康、大野恭秀 、前橋兼三、井上恒一、渡邊洋平、河原敏男、鈴木康夫、中北愼一、松本和彦
    • Organizer
      第63回応用物理学会春季学術講演会
    • Place of Presentation
      東京工業大学大岡山キャンパス (東京都目黒区)
    • Year and Date
      2016-03-20
    • Related Report
      2015 Research-status Report
  • [Presentation] シアロ糖鎖修飾による数層グラフェンインフルエンザバイオセンサーの研究開発2016

    • Author(s)
      河原敏男、玉田敦子、中北愼一
    • Organizer
      平成27年度 総合工学研究所研究発表会
    • Place of Presentation
      中部大学 (愛知県春日井市)
    • Year and Date
      2016-03-07
    • Related Report
      2015 Research-status Report
  • [Presentation] ナノカーボンバイオセンサーの医療応用研究会座長総括2016

    • Author(s)
      河原敏男
    • Organizer
      第8回 ナノカーボンバイオセンサーの医療応用研究会
    • Place of Presentation
      ウインクあいち (愛知県名古屋市)
    • Year and Date
      2016-01-28
    • Related Report
      2015 Research-status Report
  • [Presentation] 低温バッファー層を用いたCNW-FETのノイズ解析2015

    • Author(s)
      河原敏男、川際智聖、中川幸紀、大野泰秀、前橋兼三、松本和彦、岡本一将、宇都宮里佐、松葉晃明、吉村雅満、松岡佑樹
    • Organizer
      第76回応用物理学会秋季学術講演会
    • Place of Presentation
      名古屋国際会議場 (愛知県名古屋市)
    • Year and Date
      2015-09-16
    • Related Report
      2015 Research-status Report
  • [Presentation] 糖鎖機能化グラフェンFETを用いたインフルエンザウイルス由来ヘマグルチニンの検出2015

    • Author(s)
      林亮太、小野尭生、生田昂、金井康、大野恭秀、前橋兼三、井上恒一、渡邊洋平、河原敏男、鈴木康夫、中北愼一、松本和彦
    • Organizer
      第76回応用物理学会秋季学術講演会
    • Place of Presentation
      名古屋国際会議場 (愛知県名古屋市)
    • Year and Date
      2015-09-15
    • Related Report
      2015 Research-status Report
  • [Presentation] Noise Spectroscopy of Self-aligned Carbon Nanowalls2015

    • Author(s)
      T. Kawahara, Y. Ohno, K. Maehashi, K. Matsumoto, K. Okamoto, R. Utsunomiya, T. Matsuba
    • Organizer
      23rd Internationl Conference on Noise and Fluctuations (ICNF)
    • Place of Presentation
      Xidian University, Xi'An, China
    • Year and Date
      2015-06-03
    • Related Report
      2015 Research-status Report
  • [Presentation] Spreading of Influenza Virus in North Africa and Southeast Asia2015

    • Author(s)
      T. Kawahara, Y. Suzuki, A. Tamada, N. Sriwilaijaroen, K. Matsumoto
    • Organizer
      The 5th Asia-Africa Sustainable Energy Forum Jointly with 7th International Workshop on Sahara Solar Breeder
    • Place of Presentation
      30th Anniversary Hall, University of Tsukuba, Tsukuba, Japan (茨城県つくば市)
    • Year and Date
      2015-05-11
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 糖鎖修飾グラフェンFETを用いたインフルエンザウイルスセンサの開発2015

    • Author(s)
      麻植丈史, 生田昂, 林亮太, 金井康, 大野恭秀, 前橋兼三, 井上恒一, 松本和彦, 渡邊洋平, 河原敏男, 鈴木康夫, 中北愼一
    • Organizer
      第62回応用物理学会春季学術講演会
    • Place of Presentation
      東海大学湘南キャンパス(神奈川県平塚市)
    • Year and Date
      2015-03-11 – 2015-03-14
    • Related Report
      2014 Research-status Report
  • [Presentation] Electrical detection of lectin using glycan-modified graphene field-effect transistors for highly sensitive influenza virus sensor2014

    • Author(s)
      T. Oe, Y. Kanai, Y. Ohno, K. Maehashi, K. Inoue, K. Matsumoto, Y. Watanabe, T. Kawahara, Y. Suzuki, S. Nakakita
    • Organizer
      27th International Microprocesses and Nanotechnology Conference (MNC2014)
    • Place of Presentation
      Hilton Fukuoka Sea Hawk, Fukuoka, Japan (福岡県福岡市)
    • Year and Date
      2014-11-04 – 2014-11-07
    • Related Report
      2014 Research-status Report
  • [Presentation] CNW-FETプロセスへの低温バッファー層の影響2014

    • Author(s)
      河原敏男、中川幸紀、大野泰秀、前橋謙三、松本和彦、岡本一将、宇都宮里佐、松葉晃明、吉村雅満、松岡佑樹
    • Organizer
      第75回応用物理学会秋季学術講演会
    • Place of Presentation
      北海道大学札幌キャンパス(北海道札幌市)
    • Year and Date
      2014-09-17 – 2014-09-20
    • Related Report
      2014 Research-status Report
  • [Presentation] 高感度インフルエンザウイルスセンサに向けたシアロ糖鎖修飾グラフェン電界効果トランジスタを用いたレクチン検出2014

    • Author(s)
      麻植丈史, 金井康, 大野恭秀, 前橋兼三, 井上恒一, 松本和彦, 渡邊洋平, 河原敏男, 鈴木康夫, 中北愼一
    • Organizer
      第75回応用物理学会秋季学術講演会
    • Place of Presentation
      北海道大学札幌キャンパス(北海道札幌市)
    • Year and Date
      2014-09-17 – 2014-09-20
    • Related Report
      2014 Research-status Report
  • [Presentation] ナノカーボンデバイスのプロセス開発2014

    • Author(s)
      河原敏男
    • Organizer
      第1回 ナノカーボンバイオセンサーの医療応用研究会
    • Place of Presentation
      科学技術交流財団研究交流センター(愛知県名古屋市)
    • Year and Date
      2014-06-26
    • Related Report
      2014 Research-status Report
    • Invited

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Published: 2014-04-04   Modified: 2018-03-22  

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