| Project/Area Number |
26400210
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Foundations of mathematics/Applied mathematics
|
|---|
| Research Institution | Josai University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
SUZUKI Kazuo 帝京大学, アジア国際感染症制御研究所, 教授 (20192130)
KAWACHI Shohji 帝京大学, アジア国際感染症制御研究所, 教授 (60152972)
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
|
|---|
| Keywords | 数理モデル / 数値シミュレーション / 新型インフルエンザ / 白血球減少症 / シミュレーション / 体内感染症モデル / インホストモデル / H5N1 / 遅延微分方程式 / 常微分方程式 / leukopenia |
|---|
| Outline of Final Research Achievements |
In this study, we developed a numerical within-host model and performed simulations to reproduce the pathology of leukopenia peculiar to highly pathogenic avian influenza A / H 5 N1. As a mathematical model, we first developed a model by delay differential equation system. Although leukopenia could be reproduced, the system became stiff. It was difficult to combine the within-host model with a transmission model in a local community from the view point of computation time. Then, we next developed an ordinary differential equation model and identified parameters using experimental data. Furthermore, the effectiveness of neuraminidase inhibitor therapy and immunoglobulins therapy were evaluated using the ordinary differential equation model. High-speed simulation coupled with transmission model becomes possible.
|
