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Search for the liquid-ordered phase appeared in cholesterol-free lipid bilayers

Research Project

Project/Area Number 26400431
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Biological physics/Chemical physics/Soft matter physics
Research InstitutionKyoto Institute of Technology

Principal Investigator

Yao Haruhiko  京都工芸繊維大学, 材料化学系, 准教授 (60212271)

Co-Investigator(Kenkyū-buntansha) 猿山 靖夫  京都工芸繊維大学, 材料化学系, 教授 (50162532)
Research Collaborator KOMAKI Hiroyuki  京都工芸繊維大学, 材料制御化学専攻, 大学院生
YOSHIKAWA Yuki  京都工芸繊維大学, 材料制御化学専攻, 大学院生
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords脂質二分子膜 / 秩序液体相
Outline of Final Research Achievements

The liquid ordered(lo) phase in cholesterol-free lipid bilayers has been searched using ultra-high-sensitivity DSC developed in our laboratory. Multiple heat anomalies were found near the gel to liquid-crystalline phase transition of diundecanoyl phosphatidylcholine(DC11PC), ditridecanoyl phosphatidylcholine(DC13PC) and dimyristoyl phosphatidylgrycerol(DC14PG). The packing of hydrocarbon chains of the systems was investigated with X-ray diffraction. It was found that the lo phase existed as an intermediate phase near the gel to liquid-crystalline phase transition of DC11PC, DC13PC and DC14PG.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (6 results)

All 2016 2015 2014

All Presentation (6 results) (of which Invited: 1 results)

  • [Presentation] 短鎖リン脂質ホスファチジルコリンのLx相2016

    • Author(s)
      八尾晴彦、小牧裕之、三村賢人、神谷泰史、岡崎文洋、猿山靖夫
    • Organizer
      第52回熱測定討論会
    • Place of Presentation
      徳島大学
    • Year and Date
      2016-09-28
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 高感度DSCとX線回折の同時測定によるリン脂質ホスファチジルコリン-コレステロール混合系のLx相の研究2016

    • Author(s)
      小牧裕之、神谷泰史、岡崎文洋、猿山靖夫、八尾晴彦
    • Organizer
      第52回熱測定討論会
    • Place of Presentation
      徳島大学
    • Year and Date
      2016-09-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] X線回折と高感度DSCの同時測定によるリン脂質ホスファチジルコリン-コレステロール混合系のLx相の研究2016

    • Author(s)
      小牧裕之、神谷泰史、岡崎文洋、猿山靖夫、八尾晴彦
    • Organizer
      第67回コロイドおよび界面化学討論会
    • Place of Presentation
      北海道教育大学旭川校
    • Related Report
      2016 Annual Research Report
  • [Presentation] 高感度DSCとX線回折の同時測定によるリン脂質ホスファチジルコリン-コレステロール混合系のLx相の研究2015

    • Author(s)
      小牧裕之、猿山靖夫、八尾晴彦
    • Organizer
      熱測定討論会
    • Place of Presentation
      東京電機大学
    • Year and Date
      2015-10-08
    • Related Report
      2015 Research-status Report
  • [Presentation] X線回折と高感度DSCの同時測定によるリン脂質ホスファチジルコリン-コレステロール混合系のLx相の研究2015

    • Author(s)
      小牧裕之、猿山靖夫、八尾晴彦
    • Organizer
      コロイドおよび界面化学討論会
    • Place of Presentation
      鹿児島大学
    • Year and Date
      2015-09-10
    • Related Report
      2015 Research-status Report
  • [Presentation] 高感度DSCとX線回折の同時測定装置の開発2014

    • Author(s)
      三村賢人、猿山靖夫、八尾晴彦
    • Organizer
      日本熱測定学会
    • Place of Presentation
      大阪大学
    • Year and Date
      2014-09-28 – 2014-09-30
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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