Search for the liquid-ordered phase appeared in cholesterol-free lipid bilayers
| Project/Area Number |
26400431
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biological physics/Chemical physics/Soft matter physics
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| Research Institution | Kyoto Institute of Technology |
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Principal Investigator |
Yao Haruhiko 京都工芸繊維大学, 材料化学系, 准教授 (60212271)
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| Co-Investigator(Kenkyū-buntansha) |
猿山 靖夫 京都工芸繊維大学, 材料化学系, 教授 (50162532)
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| Research Collaborator |
KOMAKI Hiroyuki 京都工芸繊維大学, 材料制御化学専攻, 大学院生
YOSHIKAWA Yuki 京都工芸繊維大学, 材料制御化学専攻, 大学院生
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 脂質二分子膜 / 秩序液体相 |
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| Outline of Final Research Achievements |
The liquid ordered(lo) phase in cholesterol-free lipid bilayers has been searched using ultra-high-sensitivity DSC developed in our laboratory. Multiple heat anomalies were found near the gel to liquid-crystalline phase transition of diundecanoyl phosphatidylcholine(DC11PC), ditridecanoyl phosphatidylcholine(DC13PC) and dimyristoyl phosphatidylgrycerol(DC14PG). The packing of hydrocarbon chains of the systems was investigated with X-ray diffraction. It was found that the lo phase existed as an intermediate phase near the gel to liquid-crystalline phase transition of DC11PC, DC13PC and DC14PG.
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Report
(4 results)
Research Products
(6 results)
