| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2016: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
Protein A is oftein used for preparation of immunoglobulins. However, its conformation is solution has not known. We have used X-ray solution scattering method for obtaining the conformation of protein A and its derivatives.
Results are also compared with the structure predicted by molecular dynamics, which gives the very good coincidence. This result suggests the protein A takes the relaxed conformaton without the stress.
We have also done X-ray solution scattering study on the complex of protein A and Fc fragment of Immunoglobulin, and successfully obtained the scattering profile of the complex. Further analysis should be done.
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