• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Theoretical elucidation on the full reaction mechanisms of threonine synthase

Research Project

Project/Area Number 26410002
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Physical chemistry
Research InstitutionUniversity of Tsukuba

Principal Investigator

SHOJI MITSUO  筑波大学, 計算科学研究センター, 助教 (00593550)

Co-Investigator(Renkei-kenkyūsha) HAYASHI HIDEYUKI  大阪医科大学, 医学部, 教授 (00183913)
Research Collaborator UJIIE YUZURU  筑波大学, 数理物質系
TANAKA WATARU  筑波大学, 数理物質系
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Keywordsトレオニン合成酵素 / 反応機構 / 生成物支援機構 / QM/MM / molecular dynamics / 自由エネルギー / スパコン / 反応制御 / 反応制御機構 / 副反応経路 / molecular dynamics (MD) / スーパーコンピュータ / 量子古典混合計算 / 酵素反応
Outline of Final Research Achievements

Reaction mechanisms of the threonine synthase (ThrS) were theoretically investigated by using the mixed quantum mechanics/molecular mechanics (QM/MM) and classical molecular dynamics methods. By utilizing the supercomputers, long time scale CMD (total 3 micro sec) were performed and important protein-substrate interactions and free energy changes were elucidated. Significantly, conformational changes on the active site molecules (PLP, water and amino acid residues) were observed depending on the intermediate states. It was also shown that the anion important for the product assisted mechanism plays important role to construct active site conformations. These results clearly indicate that precise structural controls optimized for the reactions are performed in ThrS. This reaction control mechanism provides valuable insights for other reaction mechanisms and functional modifications.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (54 results)

All 2017 2016 2015 2014 Other

All Journal Article (16 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 16 results,  Open Access: 2 results,  Acknowledgement Compliant: 8 results) Presentation (30 results) (of which Int'l Joint Research: 13 results,  Invited: 11 results) Book (2 results) Remarks (6 results)

  • [Journal Article] Reaction mechanism of sarcosine oxidase elucidated using FMO and QM/MM methods2017

    • Author(s)
      Y. Abe, M. Shoji, Y. Nishiya, H. Aiba, T. Kishimoto, K. Kitaura
    • Journal Title

      Physical Chemistry Chemical Physics

      Volume: 19 Issue: 15 Pages: 9811-9822

    • DOI

      10.1039/c6cp08172j

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Large-scale QM/MM calculations of the CaMn4O5 cluster in the S3 state of the oxygen evolving complex of photosystem II. Comparison between water-inserted and no water-inserted structures.2017

    • Author(s)
      Shoji M, Isobe H, Nakajima T, Shigeta Y, Suga M, Akita F, Shen JR and *Yamazaki K.
    • Journal Title

      Faraday Discussions

      Volume: 198 Pages: 83-106

    • DOI

      10.1039/c6fd00230g

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Large-scale QM/MM calculations of the CaMn4O5 cluster in the oxygen-evolving complex of photosystem II: comparisons with EXAFS structures2016

    • Author(s)
      M. Shoji, H. Isobe, T. Nakajima, K. Yamaguchi
    • Journal Title

      Chem. Phys. Lett.

      Volume: 658 Pages: 354-363

    • DOI

      10.1016/j.cplett.2016.06.067

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular mechanisms of substrate specificities of uridine-cytidine kinase2016

    • Author(s)
      W. Tanaka, M. Shoji, F. Tomoike, Y. Ujiie, K. Hanaoka, R. Harada, M. Kayanuma, K. Kamiya, T. Ishida, R. Masui, S. Kuramitsu, Y. Shigeta
    • Journal Title

      Biophysics and Physicobiology

      Volume: 13 Issue: 0 Pages: 77-84

    • DOI

      10.2142/biophysico.13.0_77

    • NAID

      130005156955

    • ISSN
      2189-4779
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Geometric and electronic structures of the synthetic Mn4CaO4 model compound mimicking the photosynthetic oxygen-evolving complex2016

    • Author(s)
      M. Shoji, H. Isobe, J.-R. Shen, K. Yamaguchi
    • Journal Title

      Physical Chemistry Chemical Physics

      Volume: 18 Issue: 16 Pages: 11330-11340

    • DOI

      10.1039/c5cp07226c

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Catalytic Mechanism of Nitrile Hydratase Subsequent to Cyclic Intermediate Formation: A QM/MM Study2016

    • Author(s)
      M. Kayanuma, M. Shoji, M. Yohda, M. Odaka, Y. Shigeta
    • Journal Title

      The Journal of Physical Chemistry B

      Volume: 123(13) Issue: 13 Pages: 3259-3266

    • DOI

      10.1021/acs.jpcb.5b11363

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A QM/MM study of the 5'-AMP DNA hydrolysis of aprataxin2015

    • Author(s)
      K.Hanaoka, W.Tanaka, M.Kayanuma, M.Shoji
    • Journal Title

      Chemical Physics Letters

      Volume: 631-632 Pages: 16-20

    • DOI

      10.1016/j.cplett.2015.04.053

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Performance of the divide-and-conquer approach used as an initial guess2015

    • Author(s)
      M.Shoji, M.Kayanuma, H.Umeda, Y.Shigeta
    • Journal Title

      Chemical Physics Letters

      Volume: 634 Pages: 181-187

    • DOI

      10.1016/j.cplett.2015.06.011

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Full Geometry Optimizations of the CaMn4O4 Model Cluster for the Oxygen Evolving Complex of Photosystem II2015

    • Author(s)
      M.Shoji, H.Isobe, T.Nakajima, K.Yamaguchi
    • Journal Title

      Chemical Physics Letters

      Volume: 640 Pages: 23-30

    • DOI

      10.1016/j.cplett.2015.10.006

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] QM/MM Study of the S2 to S3 Transition Reaction in the Oxygen-Evolving Complex of Photosystem II2015

    • Author(s)
      M.Shoji, H.Isobe, K.Yamaguchi
    • Journal Title

      Chemical Physics Letters

      Volume: 636 Pages: 172-179

    • DOI

      10.1016/j.cplett.2015.07.039

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Light absorption and excitation energy transfer calculations in primitive photosynthetic bacteria2015

    • Author(s)
      Yu Komatsu, Megumi Kayanuma, Mitsuo Shoji, Kazuhiro Yabana, Kenji Shiraishi, Masayuki Umemura
    • Journal Title

      Molecular Physics

      Volume: 印刷中 Issue: 12 Pages: 1413-1421

    • DOI

      10.1080/00268976.2014.998305

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Light absorption efficiencies of photosynthetic pigments: the dependence on spectral types of central stars2015

    • Author(s)
      Yu Komatsu, Masayuki Umemura, Mitsuo Shoji, Megumi Kayanuma, Kazuhiro Yabana and Kenji Shiraishi
    • Journal Title

      International Journal of Astrobiology

      Volume: 印刷中 Issue: 3 Pages: 505-510

    • DOI

      10.1017/s147355041400072x

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Involvement of Propionate Side Chains of the Heme in Circular Dichroism of Myoglobin: Experimental and Theoretical Analyses2015

    • Author(s)
      1M.Nagai, C.Kobayashi, Y. Nagai, K.Imai, N.Mizusawa, H.Sakurai, S.Neya, M.Kayanuma, M.Shoji, S.Nagatomo
    • Journal Title

      J. Phys. Chem. B

      Volume: 119 Issue: 4 Pages: 1275-1287

    • DOI

      10.1021/jp5086203

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] A QM/MM Study of the Initial Steps of Catalytic Mechanism of Nitrile Hydratase2015

    • Author(s)
      M.Kayanuma, K.Hanaoka, M.Shoji, Y. Shigeta
    • Journal Title

      Chem. Phys. Lett.

      Volume: 623 Pages: 8-13

    • DOI

      10.1016/j.cplett.2015.01.039

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] A QM/MM Study of the l-Threonine Formation Reaction of Threonine Synthase: Implications into the Mechanism of the Reaction Specificity2014

    • Author(s)
      M.Shoji, K.Hanaoka, Y.Ujiie, W.Tanaka, D.Kondo, H.Umeda, Y.Kamoshida, M.Kayanuma, K.Kamiya, K.Shiraishi,Y.Machida, T.Murakawa, H.Hayashi
    • Journal Title

      Journal of the American Chemical Society

      Volume: 136

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] An Efficient Initial Guess Formation of Broken-Symmetry Solutions by using Localized Natural Orbitals2014

    • Author(s)
      M. Shoji, Y. Yoshioka, K. Yamaguchi
    • Journal Title

      Chemical Physics Letters

      Volume: 608 Pages: 50-54

    • DOI

      10.1016/j.cplett.2014.05.063

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] A quantum chemical study of the glycine formation reactions in interstellar medium2017

    • Author(s)
      M. Shoji
    • Organizer
      ABC workshop
    • Place of Presentation
      Hiroshima University(Higashi Hiroshima, Hiroshima)
    • Year and Date
      2017-03-21
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] レオニン合成酵素における生成物支援機構の理論的解明2016

    • Author(s)
      氏家謙、○庄司光男、原田隆平、村川武志、重田育照、林秀行
    • Organizer
      第54回生物物理会年会
    • Place of Presentation
      つくば国際会議場(茨城県つくば市)
    • Year and Date
      2016-11-25
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Reaction mechanisms of the S2 to S3 transition in the oxygen-evolving complex of photosytem II2016

    • Author(s)
      Mitsuo Shoji, Hiroshi Isobe, Kizashi Yamaguchi
    • Organizer
      the 17th International Congress on Photosynthesis Research
    • Place of Presentation
      MECC Maastricht, Maastricht, Netherlands
    • Year and Date
      2016-08-07
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Reaction mechanisms for the S2 to S3 transition in the oxygen-evolving complex of photosystem II2016

    • Author(s)
      Mitsuo Shoji, Hiroshi Isobe, Kizashi Yamaguchi
    • Organizer
      AWEST 2016
    • Place of Presentation
      Awaji Yumebutai , Awaji island, Awaji, Hyogo
    • Year and Date
      2016-06-19
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Large-Scale QM/MM study on the oxygen-evolving complex of photosytem II2016

    • Author(s)
      Mitsuo Shoji, Hiroshi Isobe, Kizashi Yamaguchi
    • Organizer
      79th Harden Conference: Oxygen Evolution and Reduction - Common Principles
    • Place of Presentation
      Grauer Bar Hotel, Innsbruck, Austria
    • Year and Date
      2016-04-16
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] NTChemによる光合成酸素発生中心の電子状態解析2016

    • Author(s)
      庄司光男
    • Organizer
      第五回NTChemワークショップ
    • Place of Presentation
      秋葉原UDX6階カンファレンス、東京都千代田区
    • Year and Date
      2016-03-09
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 分割統治法を用いた初期電子密度行列の効率的作成2016

    • Author(s)
      庄司光男
    • Organizer
      蛋白質研セミナー
    • Place of Presentation
      東京大学先端科学研究所、東京都目黒区
    • Year and Date
      2016-03-01
    • Related Report
      2015 Research-status Report
  • [Presentation] Possibilities of Glycine formation in interstellar medium2016

    • Author(s)
      Mitsuo Shoji
    • Organizer
      Symposium on Hierarchy and Holism in Natural Sciences
    • Place of Presentation
      国立天文台、東京都三鷹市
    • Year and Date
      2016-02-05
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 光合成酸素発生中心の電子・スピン状態の理論解析2016

    • Author(s)
      庄司光男
    • Organizer
      第55回電子スピンサイエンス学会年会(SEST2016)
    • Place of Presentation
      大阪市立大学(大阪府大阪市)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 光化学系II酸素発生中心(PSII-OEC)におけるS2-S3状態変化についての理論的研究2016

    • Author(s)
      庄司光男、磯部寛、山口兆
    • Organizer
      第89回日本生化学学会大会
    • Place of Presentation
      東北大学(宮城県仙台市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] Electronic structures of the synthetic model of the photosynthetic oxygen-evolving complex2016

    • Author(s)
      Mitsuo Shoji, Hiroshi Isobe, Jian-Ren Shen, Kizashi Yamaguchi, Yasuteru Shigeta, Yu Takano
    • Organizer
      VUVX satellite workshop
    • Place of Presentation
      University of Zurich, Zurich, Switzerland
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 宇宙空間におけるアミノ酸生成反応についての理論的研究2015

    • Author(s)
      庄司光男
    • Organizer
      第3回キラル研究会
    • Place of Presentation
      京都大学、京都府京都市
    • Year and Date
      2015-11-28
    • Related Report
      2015 Research-status Report
  • [Presentation] Theoretical elucidation on the molecular mechanism of product assited catalysis of threonine synthase2015

    • Author(s)
      Mitsuo Shoji, Tuzuru Ujiie, Megumi Kayanuma, Yasuteru Shigeta, Takeshi Murakawa, Hideyuki Hayashi
    • Organizer
      The 53rd Annual Meeting of the BSJ
    • Place of Presentation
      金沢大学、石川県金沢市
    • Year and Date
      2015-09-14
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 光化学系IIの酸素発生中心の電子状態2015

    • Author(s)
      庄司光男
    • Organizer
      総会シンポジウム、第53回生物物理学会
    • Place of Presentation
      金沢大学、石川県金沢市
    • Year and Date
      2015-09-14
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 光化学系II酸素発生中心のS2->S3状態変化についての理論的解明2015

    • Author(s)
      庄司光男、磯部寛、山口兆,重田育照、鷹野優
    • Organizer
      3D active site 第2回成果報告会
    • Place of Presentation
      筑波山京成ホテル、茨城県つくば市
    • Year and Date
      2015-09-04
    • Related Report
      2015 Research-status Report
  • [Presentation] Molecular dynamics study on the key catalytic intermediates of threonine synthase2015

    • Author(s)
      Mitsuo Shoji, Yuzuru Ujiie, Ryuhei Harada, Megumi Kayanuma, Yasuteru Shigeta, Takeshi Murakawa, Hideyuki Hayashi
    • Organizer
      29th Annual Symposium of the Protein Society
    • Place of Presentation
      Fira de Barcelona Balcelona, Balcelona , Spain
    • Year and Date
      2015-07-22
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] ヘム蛋白の特異的円二色性(Soret帯CD)についての理論的解明2015

    • Author(s)
      庄司光男、栢沼愛、重田教育照、長友重紀、長井雅子
    • Organizer
      蛋白質科学会
    • Place of Presentation
      あわぎんホール、徳島県徳島市
    • Year and Date
      2015-06-24
    • Related Report
      2015 Research-status Report
  • [Presentation] QM/MM Study on the Reaction Mechanism of Assimilatory Nitrite Reductase (aNiR)2015

    • Author(s)
      Mitsuo Shoji
    • Organizer
      Metals in Biology in Wako
    • Place of Presentation
      理化学研究所、埼玉県和光市
    • Year and Date
      2015-06-16
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] QM/MM study on the possible reactions of Photosystem II oxygen evolving complex in the S2 to S3 transition2015

    • Author(s)
      Mitsuo Shoji
    • Organizer
      3rd AWEST
    • Place of Presentation
      淡路夢舞台、兵庫県淡路市
    • Year and Date
      2015-06-14
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 分割統治法を用いた初期電子密度行列の構築2015

    • Author(s)
      庄司光男, 栢沼愛, 梅田宏明, 重田育照
    • Organizer
      第18回理論化学討論会2015
    • Place of Presentation
      大阪大学、大阪府豊中市
    • Year and Date
      2015-05-20
    • Related Report
      2015 Research-status Report
  • [Presentation] 宇宙空間でのアミノ酸生成についての理論的研究2014

    • Author(s)
      庄司光男
    • Organizer
      「実験・観測・計算シナジーによる自然界における生体分子の非対称性起源の解明」
    • Place of Presentation
      分子科学研究所、愛知県
    • Year and Date
      2014-11-29
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] QM/MM study on the L-threonine formation reaction of threonine synthase2014

    • Author(s)
      Mitsuo Shoji, Yuzuru Ujiie, Wataru Tanaka, Megumi Kayanuma, Ryuhei Harada, Hiroaki Umeda, Yasuteru Shigeta, Takeshi Murakawa, Hideyuki Hayashi
    • Organizer
      QSCP XIX
    • Place of Presentation
      Tamkang University, Taipei, Taiwan
    • Year and Date
      2014-11-11 – 2014-11-17
    • Related Report
      2014 Research-status Report
  • [Presentation] トレオニン合成酵素における生成物支援触媒機構解明のための精密自由エネルギー計算2014

    • Author(s)
      庄司光男, 氏家謙, 田中弥, 栢沼愛, 梅田宏明, 重田育照, 村川武志, 林秀行
    • Organizer
      日本生化学会大会(ポスター)
    • Place of Presentation
      京都国際会議場、京都府
    • Year and Date
      2014-10-15 – 2014-10-18
    • Related Report
      2014 Research-status Report
  • [Presentation] Theoretical investigation on the conformation-charge relationship of the photosystem II oxygen evolving complex (PSII-OEC)2014

    • Author(s)
      Mitsuo Shoji, Hiroshi Isobe, Shusuke Yamanaka, Jian-Ren Shen, Kizashi Yamaguchi
    • Organizer
      第52回日本生物物理学会年会
    • Place of Presentation
      札幌コンベンションセンター、北海道
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Research-status Report
  • [Presentation] 同化型亜硝酸還元酵素における全化学反応の理論的解明2014

    • Author(s)
      庄司光男、田中弥、氏家譲、栢沼愛、梅田宏明、重田育照、中野祥吾、片柳克夫
    • Organizer
      分子科学討論会(口頭発表)
    • Place of Presentation
      広島大学、広島県
    • Year and Date
      2014-09-21 – 2014-09-24
    • Related Report
      2014 Research-status Report
  • [Presentation] QM/MM study of the L-threonine formation reaction of threonine synthase: mechanism of the product-assisted catalysis2014

    • Author(s)
      Mitsuo Shoji, Y.Ujiie, W.Tanaka, M.Kayanuma, R.Harada, H.Umeda, Y.Shigeta, T.Murakawa, H.Hayashi
    • Organizer
      computational science workshop 2014 (oral)
    • Place of Presentation
      筑波国際会議場、茨城県
    • Year and Date
      2014-08-22
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 同化型亜硝酸還元酵素の反応機構の理論的解明2014

    • Author(s)
      庄司 光男、田中 弥 、氏家 謙 、栢沼 愛 、梅田 宏明、中野 祥吾 、片柳 克夫
    • Organizer
      第14回蛋白質科学会(ポスター)
    • Place of Presentation
      ワークピア横浜、神奈川県
    • Year and Date
      2014-06-25 – 2014-06-27
    • Related Report
      2014 Research-status Report
  • [Presentation] A development of the computational biosciences with supercomputers2014

    • Author(s)
      Mitsuo Shoji
    • Organizer
      AWEST2014
    • Place of Presentation
      淡路夢舞台、兵庫県
    • Year and Date
      2014-06-17
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] QM/MM 法によるトレオニン合成酵素の反応制御機構の理論解明2014

    • Author(s)
      庄司光男,氏家謙,田中弥,栢沼愛,梅田宏明,村川武,林秀行,重田育照
    • Organizer
      理論化学討論会
    • Place of Presentation
      名古屋大学、愛知県
    • Year and Date
      2014-05-22
    • Related Report
      2014 Research-status Report
  • [Presentation] QM/MM法による酵素反応機構の理論的解明2014

    • Author(s)
      庄司光男
    • Organizer
      CUTE Mini-Workshop
    • Place of Presentation
      三重大学、三重県
    • Year and Date
      2014-05-21
    • Related Report
      2014 Research-status Report
    • Invited
  • [Book] 金属錯体の量子・計算化学”、錯体化学会選書102014

    • Author(s)
      庄司光男(山口兆、榊茂好、増田秀樹編著)
    • Publisher
      三共出版
    • Related Report
      2014 Research-status Report
  • [Book] Adv. Quantum. Chem (Large-Scale QM/MM Calculations of Hydrogen Bonding Networks for Proton Transfer and Water Inlet Channels for Water Oxidation―Theoretical System Models of the Oxygen-Evolving Complex of Photosystem II)2014

    • Author(s)
      M. Shoji, H. Isobe, S. Yamanaka, Y. Umena, K. Kawakami, N. Kamiya, J.-R. Shen
    • Publisher
      Elsevier
    • Related Report
      2014 Research-status Report
  • [Remarks] 研究室ホームページでの業績公開 (2016年)

    • URL

      http://www2.ccs.tsukuba.ac.jp/people/mshoji/research_2016.html

    • Related Report
      2016 Annual Research Report
  • [Remarks] 研究室ホームページでの業績公開 (2017年)

    • URL

      http://www2.ccs.tsukuba.ac.jp/people/mshoji/research_2017.html

    • Related Report
      2016 Annual Research Report
  • [Remarks] 研究室ホームページでの業績公開

    • URL

      http://www2.ccs.tsukuba.ac.jp/people/mshoji/research_2015.html

    • Related Report
      2015 Research-status Report
  • [Remarks] 研究室ホームページ、研究成果

    • URL

      http://www2.ccs.tsukuba.ac.jp/people/mshoji/index.html

    • Related Report
      2014 Research-status Report
  • [Remarks] 研究成果プレスリリース(筑波大学&大阪医科大学)

    • URL

      http://www.ccs.tsukuba.ac.jp/press_threonine_140314

    • Related Report
      2014 Research-status Report
  • [Remarks] 記事掲載(QLife)

    • URL

      http://www.qlifepro.com/news/20140326/the-university-of-tsukuba-supercomputer-reveals-the-final-process-of-threonine-biosynthesis.html

    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi