| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Outline of Final Research Achievements |
Crystal formation from the solution is essential in fundamental science as well as the fabrication of pharmaceuticals, food, polymers and organic solid materials. In solution crystallization, the formation of crystal nuclei plays an important role in determining the crystal structure, size, and polymorph. We have developed the fluorescence microscopy that can detect the changes of the fluorescence and weight of the droplet simultaneously. We investigate the fluorescence properties of the boron difluoride complexes solution during evaporative crystallization.
We have found that crystals of boron difluoride complexes can be formed from monomer species via an amorphous state, which is formed prior to crystal formation. This study has clearly confirmed the two-step nucleation model by measuring fluorescence color changes. The present method also enables us to achieve the observation for the polymorphic appearance of organic crystal formation.
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