| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Outline of Final Research Achievements |
In this study, free energy analysis based on molecular dynamics simulation was carried out for the binding/fusion process of two spherical micelles and the binding/fusion process of the spherical micelle to the lipid membrane surface. As a target system, SDS micelle, which is a representative spherical micelle, and a planar membrane patch of a lipid bilayer membrane composed of POPC as a model of a real cell membrane were used. Molecular level mechanism of fusion process due to thermal fluctuation was elucidated, and time constants required for micelle binding and fusion were evaluated.
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