Molecular mechanism of micelle binding and fusion process to lipid membranes
Project/Area Number |
26410012
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Physical chemistry
|
Research Institution | Nagoya University |
Principal Investigator |
Yoshii Noriyuki 名古屋大学, 工学研究科, 特任准教授 (70371599)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
Keywords | 分子動力学計算 / ミセル / 脂質膜 / 化学物理 / 分子シミュレーション / 自由エネルギー計算 / 自由エネルギー |
Outline of Final Research Achievements |
In this study, free energy analysis based on molecular dynamics simulation was carried out for the binding/fusion process of two spherical micelles and the binding/fusion process of the spherical micelle to the lipid membrane surface. As a target system, SDS micelle, which is a representative spherical micelle, and a planar membrane patch of a lipid bilayer membrane composed of POPC as a model of a real cell membrane were used. Molecular level mechanism of fusion process due to thermal fluctuation was elucidated, and time constants required for micelle binding and fusion were evaluated.
|
Report
(4 results)
Research Products
(27 results)