Development of catalytic fluorination reactions based on sigma-bond metathesis
| Project/Area Number |
26410045
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Organic chemistry
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | ヒドロフッ素化 / カルボフッ素化 / アルキン / エポキシド / σボンドメタセシス / ヒドロフッソ化 / 銅触媒 |
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| Outline of Final Research Achievements |
This project was focused on the development of fluorination reaction using safe and cheap fluorinating reagents. The developed catalytic fluorination reactions are as follows. (1) By reacting allene with aryl iodides and cesium fluoride in the presence of a palladium catalyst, the addition reaction of aryl group and fluorine proceeded. (2) By reacting alkyne with benzoyl fluoride and a tertiary alcohol in the presence of a copper catalyst, hydrofluorination reaction took place to give fluorinated alkene derivatives. (3) By treating the epoxide with benzoyl fluoride in the presence of a copper catalyst, aroylfluorination of epoxides occurred to yield fluorinated esters via C-O bond cleavage.
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Report
(4 results)
Research Products
(46 results)
