Oxidative cross-coupling of enolate species
| Project/Area Number |
26410046
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Organic chemistry
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| Research Institution | Osaka University |
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Principal Investigator |
Amaya Toru 大阪大学, 工学研究科, 助教 (20397615)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
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| Keywords | 酸化的クロスカップリング / ボロンエノラート / バナジウム / シリルエノラート / 酸化的カップリング |
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| Outline of Final Research Achievements |
Oxidative cross-coupling of enolate species is a useful reaction to synthesize unsymmetrical 1,4-dicarbonyl compounds directly from two different enolate species. However, the formation of homo-coupling product has been an issue in this reaction. In this study, we aimed to develop a method for the selective oxidative cross-coupling of enolate species. The key of our strategy is based on the control of the reactivity by the counter cation metal species of the enolate. As a result, we achieved to demonstrate that the oxidative cross-coupling proceeds selectively by combining boron enolate and silyl enolate in the presence of vanadium (V) as an oxidant.
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Report
(5 results)
Research Products
(18 results)
