| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
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| Outline of Final Research Achievements |
Oxidative cross-coupling of enolate species is a useful reaction to synthesize unsymmetrical 1,4-dicarbonyl compounds directly from two different enolate species. However, the formation of homo-coupling product has been an issue in this reaction. In this study, we aimed to develop a method for the selective oxidative cross-coupling of enolate species. The key of our strategy is based on the control of the reactivity by the counter cation metal species of the enolate. As a result, we achieved to demonstrate that the oxidative cross-coupling proceeds selectively by combining boron enolate and silyl enolate in the presence of vanadium (V) as an oxidant.
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