| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Intramolecular photocyclization by use of flow micro reactor was examined for synthesis of novel heterocyclic compounds in highly efficient and selective photoreaction. Irradiation of benzene solution containing 1-cyanonaphthalene derivatives tethered by prenyl or vinyloxy group at 2- or 4-position afforded intramolecular [2+2] photocycloadduct as heterocyclic compound. The photoreaction using flow micro reactor (1 mm diameter, 2-5 m length FEP tubing) was much faster than that in the batch system (10 mm diameter, 20 cm length, Pyrex glass tubing). Similar photoreaction of phenanthrene and aniline tethered by methylene chain (n=2~5) afforded spiro-compounds (n=3, 5) and 9-methylene-9,10-dihydrophenanthrene (n=2) in high yields when flow micro reactor system was used.
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