| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
The Fe2/O2-mediated oxidation reactions such as arene hydroxylation and C-H bond oxidation of alkanes are of current interest for understanding the reaction mechanism of dioxygen activating non-heme diiron enzymes such as soluble methane monooxygenase (sMMO) and toluene monooxygenase (TMO) and utilizing metal complexes as oxidation catalysis. Various synthetic (peroxo)diiron(III) model complexes have been developed, however, there are few functional models that exhibit oxidation reactivity and O-O bond cleavage similar to those of (peroxo)diiron(III) species in non-heme diiron enzymes. In this study, (peroxo)diiron(III) complexes having a bridging ligand (oxo or carboxylate) were prepared and their oxidation reacvtivities towards external substrates were studied. We found a mechanistic evidence that a diiron(IV)-oxo species derived from the O-O bond cleavage of (peroxo)diiron(III) species is involved in the oxidation reaction as an active oxidant.
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