| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
At present, ammonia, produced by the Haber-Bosch process, is the only nitrogen source for the industrial preparation of nitrogen-containing organic products. Although the activation and functionalization of N2 under milder conditions have received much recent interest, studies on the direct use of N2 as a feedstock for organic synthesis are still in their infancy.
We have found that the titanium diimide/dinitride complex, formed by activation of N2 with H2 and the titanium trialkyl complex, served as a unique platform for the synthesis of nitriles through reaction with acid chlorides. This protocol features simple reaction condition, no requirement for extra reagents, and unprecedented functional group tolerance. 15N-Isotope labeled nitriles can also be efficiently prepared by using the 15N-enriched diimide/dinitride analogue derived from 15N2 gas. The titanium complexes could be recycled by treatment of the crude reaction mixture with HCl.
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