Development of one-pot enantioselective construction of densely functionalized bicyclic compound using organocatalyst
| Project/Area Number |
26410121
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Synthetic chemistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 有機分子触媒 / Michael反応 / 不斉合成 / エナンチオ選択性 / 有機触媒 |
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| Outline of Final Research Achievements |
In this research, one-pot asymmetric construction of densely functionalized bicyclic compound by successive Michael reactions of cyclohexanone derivatives and acrylate derivatives bearing a leaving group was investigated. The enantioselective intramolecular Michael reaction of cyclohexanone derivatives and acrylate derivatives, which is essential for the asymmetric construction, was achieved by using quaternary ammonium salt derived from cinchona alkaloid. On the basis of the enantioselective Michael reaction, one-pot asymmetric construction of densely functionalized bicyclic compounds was also achieved.
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Report
(4 results)
Research Products
(21 results)
