Developments of the absolute asymmetric synthesis of optically active derivatives of amino acids with the dynamic preferential crystallization
| Project/Area Number |
26410124
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Synthetic chemistry
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| Research Institution | Chiba Institute of Technology |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
坂本 昌巳 千葉大学, 大学院工学研究科, 教授 (00178576)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 不斉合成 / 不斉増幅現象 / 有機結晶 / コングロメレート / 絶対不斉合成 |
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| Outline of Final Research Achievements |
We demonstrated a new asymmetric synthesis involving a reaction of an achiral substrate in a solution followed by dynamic crystallization. The asymmetric induction and amplification has been clarified by the fact that chiral products are generated by the reaction of achiral compounds and racemization and preferential crystallization of the chiral center generated simultaneously occur in the system. Using this methodology, absolute asymmetric synthesis of amino acid derivatives and medicinal intermediates were achieved. We could disseminate innovative research results widely both in Japan and abroad.
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Report
(4 results)
Research Products
(26 results)
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[Presentation] 動的優先晶出法を用いた不斉合成法の開発2016
Author(s)
上村直弘, 白附洸, 笠嶋義夫, 吉田泰志, 三野孝, 坂本昌巳
Organizer
第60回 香料・テルペンおよび精油化学に関する討論会
Place of Presentation
東京農業大学オホーツクキャンパス（北海道網走市）
Year and Date
2016-10-29
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[Presentation] アミノ酸誘導体の絶対不斉合成2015
Author(s)
梶優輝・石川紘輝・笠嶋義夫・三野孝・坂本昌巳
Organizer
シンポジウム モレキュラー・キラリティー2015
Place of Presentation
早稲田大学西早稲田キャンパス（東京都新宿区）
Year and Date
2015-06-12
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