| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
We reported that the chiral (CH2)2-bridged azolium salt bearing hydroxy-amide group or the corresponding N-heterocyclic carbene (NHC)-Ag complex promoted the Cu-catalyzed asymmetric conjugate addition reaction.
Interestingly, the reversal of enantioselectivity was achieved by changing the order of addition of starting materials. When dialkyl zinc was added to THF solution containing CuOTf, NHC-Ag complex (or azolium salt) and enone, the reaction produced the corresponding 1,4-adduct (Method A).
In contrast, the enantioselectivity of the 1,4-addition reaction was reversed when enone was added to the mixture of a Cu(I) salt, NHC-Ag complex and dialkyl zinc (Method B).
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