Chiral stationary phases consisting of p-conjugated polymers bearing glucose-linked biphenyl units: Reversible switching of recognition abilities based on coil-to-helix transition
| Project/Area Number |
26410129
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Polymer chemistry
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| Research Institution | Kanazawa University |
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Principal Investigator |
Ikai Tomoyuki 金沢大学, 物質化学系, 准教授 (90402495)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 共役高分子 / スイッチング / キラリティー / グルコース / 高次構造 / 光学分割 / コンホメーション / 軸不斉 |
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| Outline of Final Research Achievements |
An optically active p-conjugated polymer (poly-1) consisting of alternating thieno[3,4-b]thiophene and glucose-linked biphenyl units was synthesized. We found that poly-1 undergoes a conformational transition between random-coil and helix in both solution and the solid state in response to the external solvent environment. Coated-type chiral stationary phases (CSPs) were prepared from both the random-coil and helical poly-1, and the influence of the polymer backbone structure on chiral recognition ability was evaluated. The two CSPs showed complementary resolution abilities. In addition, an immobilized-type CSP with universal solvent durability was also prepared using an alkyne-appended poly-1 analogue and an azide-functionalized silica gel. The resulting CSP displayed repeatable switching of the chiral recognition ability based on a coil-to-helix transition of the polymer backbone by alternate column treatment with common organic solvents, such as chloroform and acetonitrile.
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Report
(4 results)
Research Products
(17 results)
