| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
A synthetic procedure for a novel polyrotaxane derivative called "one-ring-one-chain type polyrotaxane" was established. Monoazido-alpha-CD was synthesized and purified utilizing reversed phase column chromatography in several gram scale. The obtained monoazido-CD was mixed with terminally aminated PEG to yield an inclusion complex, followed by terminal end-cap reaction with sodium 2,4,6-trinitrobenzene sulfonate to obtain a polyrotaxane with monoazido-CD rings. The obtained polyrotaxane was further subjected to click reactions with mPEG having terminal propargyl groups, obtaining a desired one-ring-one-chain type polyrotaxane. The obtained product indicated a so-called "arrested melting behavior", i.e. a sharp exotherm around the melting temperature of side chain polymers (mPEG2000 in this case) without melting of the whole bulk polymer.
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