Molecular design of the hydrophobic interactions for stimuli-responsive polymers

• Project/Area Number: 26410137
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Polymer chemistry
• Research Institution: Fukuoka University
• Principal Investigator: Katsumoto Yukiteru 福岡大学, 理学部, 准教授 (90351741)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 水系刺激応答性高分子 / 疎水性相互作用 / マルチブロック高分子 / PEO-PPO交互マルチブロック / PEO-PPO 交互マルチブロックコポリマー / テレケリックpoly(oxazoline) / 相分離 / ヒステリシス / 高分子ミセル / 高分子末端制御 / 感熱応答性 / 立体制御

Outline of Final Research Achievements

The micellization and phase behavior of the PEO-PPO AMB copolymers in water have been investigated. The turbidity measurement has been carried out for monitoring the cloud point (Tc). The concentration dependence of Tc clearly indicates that the polymer aqueous solution undergoes the phase separation with a lower critical solution temperature. The fluorescent probe method suggests that the 20 nm aggregates have the hydrophobic core like a micelle. The micellization entropy suggested that the hydrophobic interaction between PPO blocks induces the thermoresponsiveness of the PEO-PPO AMB copolymers in water. Hysteresis of the phase change temperature (Tpc) of stereo-controlled poly(N-isopropylacrylamide) (PNiPAm) in aqueous solutions has also investigated. It is found for PNiPAm with the 46 % mess content (m) that the difference between Tpc(h) and Tpc(c) becomes ignorable when the polymer concentration goes down to 0.01 wt%, while that for PNiPAm with m=55 % remains to be 5 °C.

Research Products

• [Journal Article] Effects of Syndiotacticity on the Dynamic and Static Phase Separation Properties of Poly(N-isopropylacrylamide) in Aqueous Solution (2016)
  • Author(s): Takanori Tada, Tomohiro Hirano, Koichi Ute, Yukiteru Katsumoto, Taka-Aki Asoh, Tatsuya Shoji, Noboru Kitamura, Yasuyuki Tsuboi
  • Journal Title: J. Phys Chem. B Volume: 120 Issue: 31 Pages: 7724-7730
  • DOI: 10.1021/acs.jpcb.6b03200
  • NAID: 120006550807
  • URL: https://ocu-omu.repo.nii.ac.jp/records/2020526
  • Peer Reviewed
• [Journal Article] Solvent-Dependent Properties and Higher-Order Structures of Aryl Alcohol + Surfactant Molecular Gels (2016)
  • Author(s): S. Katsube, M. Kinoshita, K. Amano, T. Sato, Y. Katsumoto, T. Umecky, T. Takamuku, T. Kaji, M. Hiramoto, Y. Tsurunaga, K. Nishiyama
  • Journal Title: Langmuir Volume: 32 Issue: 17 Pages: 4352-4360
  • DOI: 10.1021/acs.langmuir.6b01109
  • Peer Reviewed
• [Journal Article] Supramolecular Porphyrin Copolymer Assembled through Host-Guest Interactions and Metal-Ligand Coordination (2015)
  • Author(s): K. Kinjo, T. Hirao, S. Kihara, Y. Katsumoto, ant T. Haino
  • Journal Title: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION Volume: 54 Pages: 14830-14834
  • Peer Reviewed
• [Journal Article] Reconsidering the activation entropy for anomerization of glucose and mannose in water studied by NMR spectroscopy (2015)
  • Author(s): Ami Kosaka, Misako Aida, and Yukiteru Katsumoto
  • Journal Title: Journal of Molecular Structure Volume: 1093 Pages: 195-200
  • DOI: 10.1016/j.molstruc.2015.03.038
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Structures of Naphthol-AOT Self-assembly Organogels and Their Applications to Dispersing Media of Rare-earth Complexes (2014)
  • Author(s): Katsube, S; Harada, T; Umecky, T; Takamuku, T; Kaji, T; Hiramoto, M; Katsumoto, Y; Nishiyama, K
  • Journal Title: CHEMISTRY LETTERS Volume: 43 Pages: 1861-1863
  • NAID: 130004687288
  • Peer Reviewed
• [Journal Article] Transient Reciprocating Motion of a Self-Propelled Object Controlled by a Molecular Layer of a N-Stearoyl-p-nitroaniline: Dependence on the Temperature of an Aqueous Phase (2014)
  • Author(s): Nakata, S; Ueda, T; Miyaji, T; Matsuda, Y; Katsumoto, Y; Kitahata, H; Shimoaka, T ; Hasegawa, T
  • Journal Title: JOURNAL OF PHYSICAL CHEMISTRY C Volume: 118 Pages: 14888-14893
  • Peer Reviewed
• [Journal Article] Kinetic Aspect on Gelation Mechanism of Tetra-PEG Hydrogel (2014)
  • Author(s): Nishi, Kengo; Fujii, Kenta; Katsumoto, Yukiteru; Sakai, Takamasa; Shibayama, Mitsuhiro
  • Journal Title: MACROMOLECULES Volume: 47 Pages: 3274-3281
• [Presentation] 水溶液中におけるPEO-PPOマルチブロックおよびトリブロックコポリマーのミセル形成 (2017)
  • Author(s): 力山和晃, 古賀尚之, 勝本之晶
  • Organizer: 高分子基礎研究会2016
  • Place of Presentation: かんぽの宿 鳥羽(三重)
  • Year and Date: 2017-01-27
• [Presentation] 高分子水溶液の相変化ヒステリシスの立体規則度による系統的変化 (2017)
  • Author(s): 濵村健人, 勝本之晶
  • Organizer: 高分子基礎研究会2016
  • Place of Presentation: かんぽの宿 鳥羽(三重)
  • Year and Date: 2017-01-27
• [Presentation] P(NdMAm)ミクロハイドロゲル水分散液の粘性挙動に対するコモノマーの影響 (2017)
  • Author(s): 芳野賢将，高田晃彦，真田雄介，勝本之晶
  • Organizer: 高分子基礎研究会2016
  • Place of Presentation: かんぽの宿 鳥羽(三重)
  • Year and Date: 2017-01-27
• [Presentation] 熱応答性高分子の水溶液中での凝集・解離と脱水和・水和の関係 (2017)
  • Author(s): 池本澪加，濵村健人，真田雄介，勝本之晶
  • Organizer: 高分子基礎研究会2016
  • Place of Presentation: かんぽの宿 鳥羽(三重)
  • Year and Date: 2017-01-27
• [Presentation] 熱応答性高分子水溶液における相分離のヒステリシス～α,ω-OH Poly(2-isopropyl-2-oxazoline)～ (2017)
  • Author(s): 戸次崇彰，濵村健人，真田雄介，勝本之晶
  • Organizer: 高分子基礎研究会2016
  • Place of Presentation: かんぽの宿 鳥羽(三重)
  • Year and Date: 2017-01-27
• [Presentation] Hysteresis in the thermos-responsiveness of theα,ω-hydroxyl telechelic poly(2-isopropyl-2-oxazoline) in water. (2016)
  • Author(s): Takaaki Bekki, Kento Hamamura, Yusuke Sanada and Yukiteru Katsumoto
  • Organizer: 2016 GLOBAL RESEARCH EFFORTS ON ENERGY AND NANOMATERIALS
  • Place of Presentation: 台北（台湾）
  • Year and Date: 2016-12-22
• [Presentation] Study on the hysteresis of hydration and dehydration processes for PNiPAm and PNdEAm in water by fluorescence probe method. (2016)
  • Author(s): Reika Ikemoto, Kento Hamamura, Yusuke Sanada and Yukiteru Katsumoto
  • Organizer: 2016 GLOBAL RESEARCH EFFORTS ON ENERGY AND NANOMATERIALS
  • Place of Presentation: 台北（台湾）
  • Year and Date: 2016-12-22
• [Presentation] Impact of the Primary Structure on the Thermoresponsiveness of Amphiphilic Polymers in Water (2016)
  • Author(s): Yukiteru Katsumoto
  • Organizer: 2016 GLOBAL RESEARCH EFFORTS ON ENERGY AND NANOMATERIALS
  • Place of Presentation: 台北（台湾）
  • Year and Date: 2016-12-22
  • Int'l Joint Research / Invited
• [Presentation] Thermoresponsive self-assembling behavior of PEO-PPO block copolymers in aqueous solution (2016)
  • Author(s): Yusuke Sanada, Naoyuki Koga, Tasuku Horiuchi and Yukiteru Katsumoto
  • Organizer: The 11th International Polymer Conference
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 2016-12-13
  • Int'l Joint Research
• [Presentation] Hysteresis on the phase separation of the aqueous solution of thermo-responsive polymers VII~α, ω-hydroxyl telechelic poly(2-isopropyl-2-oxazoline). (2016)
  • Author(s): Takaaki Bekki, Kento Hamamura, Yusuke Sanada and Yukiteru Katsumoto
  • Organizer: The 11th International Polymer Conference
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 2016-12-13
  • Int'l Joint Research
• [Presentation] The effect of comonomer on the viscous behavior for the aqueous dispersion of Poly(N, N-dimethylacrylamide) micro hydrogels (2016)
  • Author(s): Takamasa Yoshino and Yukiteru Katsumoto
  • Organizer: The 11th International Polymer Conference
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 2016-12-13
  • Int'l Joint Research
• [Presentation] Hysteresis on the phase separation of the aqueous solution of thermo-responsive polymers VIII ~Relation between aggregation and dehydration process of PNiPAm by fluorescence probe method~ (2016)
  • Author(s): Reika Ikemoto, Kento Hamamura, Yusuke Sanada and Yukiteru Katsumoto
  • Organizer: The 11th International Polymer Conference
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 2016-12-13
  • Int'l Joint Research
• [Presentation] Micellization behaviors of PEO-PPO multi-block copolymer and triblock copolymer in aqueous solution (2016)
  • Author(s): Kazuaki Rikiyama, Naoyuki Koga and Yukiteru Katsumoto
  • Organizer: The 11th International Polymer Conference
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 2016-12-13
  • Int'l Joint Research
• [Presentation] The viscous behavior for the aqueous dispersion of poly(N-isopropylacrlyamide) micro hydrogels (2016)
  • Author(s): Miho Iwamoto, Takamasa Yoshino and Yukiteru Katsumoto
  • Organizer: The 11th International Polymer Conference
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 2016-12-13
  • Int'l Joint Research
• [Presentation] 熱応答性高分子水溶液の相分離におけるヒステリシスVII～両末端にOH基を有するPoly(2-isopropyl-2-oxazoline)～ (2016)
  • Author(s): 戸次崇彰，濵村健人，真田雄介，勝本之晶
  • Organizer: 第65回高分子討論会
  • Place of Presentation: 神奈川大学
  • Year and Date: 2016-09-14
• [Presentation] 熱応答性高分子水溶液の相分離におけるヒステリシスVI～蛍光プローブ法によるPNiPAmの水和，脱水和過程の検討～ (2016)
  • Author(s): 池本澪加，濵村健人，真田雄介，勝本之晶
  • Organizer: 第65回高分子討論会
  • Place of Presentation: 神奈川大学
  • Year and Date: 2016-09-14
• [Presentation] Poly(N,N-dimethylacrylamide)ミクロゲル水分散液の粘性挙動に対するコモノマーの影響 (2016)
  • Author(s): 芳野賢将，真田雄介，勝本之晶
  • Organizer: 第65回高分子討論会
  • Place of Presentation: 神奈川大学
  • Year and Date: 2016-09-14
• [Presentation] 水溶液中における熱応答性PEO-PPO交互マルチブロックコポリマーの凝集挙動に対するブロック鎖長の影響 (2016)
  • Author(s): 堀内輔，真田雄介，勝本 之晶
  • Organizer: 第65回高分子討論会
  • Place of Presentation: 神奈川大学
  • Year and Date: 2016-09-14
• [Presentation] 水溶液中におけるPEO-PPOマルチブロックコポリマーのミセル形成 (2016)
  • Author(s): 力山 和晃, 古賀 尚之, 勝本 之晶
  • Organizer: 第65回高分子討論会
  • Place of Presentation: 神奈川大学
  • Year and Date: 2016-09-14
• [Presentation] 熱応答性 PEO-PPO マルチブロックコポリマー水溶液の相分離過程~ブロック鎖長の影響~ (2016)
  • Author(s): 堀内輔，勝本之晶
  • Organizer: 第65回高分子学会年次大会
  • Place of Presentation: 神戸国際会議場・展示場
  • Year and Date: 2016-05-25
• [Presentation] 熱応答性高分子水溶液の相分離におけるヒステリシスIV ~PNiPAmの分子量分布による影響とモノマーモデル水溶液との比較~ (2016)
  • Author(s): 濵村健人，勝本之晶
  • Organizer: 第65回高分子学会年次大会
  • Place of Presentation: 神戸国際会議場・展示場
  • Year and Date: 2016-05-25
• [Presentation] poly(ethylene oxide)-poly(propylene oxide)マルチブロックコポリマーの立体配座における特異性 (2016)
  • Author(s): 勝本之晶，森田后祐
  • Organizer: 第65回高分子学会年次大会
  • Place of Presentation: 神戸国際会議場・展示場
  • Year and Date: 2016-05-25
• [Presentation] 熱応答性PEO-PPOマルチブロックコポリマーの水溶液中における段階的凝集過程 (2016)
  • Author(s): 堀内 輔，勝本 之晶
  • Organizer: 高分子基礎研究会2015
  • Place of Presentation: 湯布院FITセミナーハウス
  • Year and Date: 2016-01-29
• [Presentation] 熱応答性高分子水溶液の相分離におけるヒステリシスⅢ～PNiPAmの分子量分布とモノマー水溶液の検討～ (2016)
  • Author(s): 濵村健人，勝本之晶
  • Organizer: 高分子基礎研究会2015
  • Place of Presentation: 湯布院FITセミナーハウス
  • Year and Date: 2016-01-29
• [Presentation] ウシ血清アルブミンの構造変化がPEO-PPOマルチブロックコポリマーとの会合に与える影響 (2016)
  • Author(s): 力山和晃，勝本之晶
  • Organizer: 高分子基礎研究会2015
  • Place of Presentation: 湯布院FITセミナーハウス
  • Year and Date: 2016-01-29
• [Presentation] Acrylamide 系 microhydrogel の粘度測定 (2016)
  • Author(s): 芳野賢将，勝本之晶
  • Organizer: 高分子基礎研究会2015
  • Place of Presentation: 湯布院FITセミナーハウス
  • Year and Date: 2016-01-29
• [Presentation] 両末端を OH 基に修飾した PiPrOx の曇点測定とヒステリシスの観察 (2016)
  • Author(s): 戸次崇彰，勝本之晶
  • Organizer: 高分子基礎研究会2015
  • Place of Presentation: 湯布院FITセミナーハウス
  • Year and Date: 2016-01-29
• [Presentation] 純液体Decalinの立体配座と物性の関連 (2016)
  • Author(s): 池本澪加，勝本之晶，村田義夫
  • Organizer: 高分子基礎研究会2015
  • Place of Presentation: 湯布院FITセミナーハウス
  • Year and Date: 2016-01-29
• [Presentation] PNiPAm水溶液の相分離におけるヒステリシス～分子量分布とモノマーの検討～ (2016)
  • Author(s): 濵村健人，勝本之晶
  • Organizer: 平成27年度 物理化学インターカレッジセミナー
  • Place of Presentation: 福岡大学セミナーハウス
  • Year and Date: 2016-01-09
• [Presentation] 両末端修飾されたPoly(2-isopropyl-2-oxazoline) の濁度測定とヒステリシスの観察 (2016)
  • Author(s): 戸次崇彰，勝本之晶
  • Organizer: 平成27年度 物理化学インターカレッジセミナー
  • Place of Presentation: 福岡大学セミナーハウス
  • Year and Date: 2016-01-09
• [Presentation] Poly(dimethyl acryl amide)microhydrogel の粘性測定 (2016)
  • Author(s): 芳野賢将，勝本之晶
  • Organizer: 平成27年度 物理化学インターカレッジセミナー
  • Place of Presentation: 福岡大学セミナーハウス
  • Year and Date: 2016-01-09
• [Presentation] Decalinの立体異性体と純液体物性の関連 (2016)
  • Author(s): 池本澪加，勝本之晶，村田義夫
  • Organizer: 平成27年度 物理化学インターカレッジセミナー
  • Place of Presentation: 福岡大学セミナーハウス
  • Year and Date: 2016-01-09
• [Presentation] 両親媒性マルチブロック高分子水溶液 (2016)
  • Author(s): 勝本之晶
  • Organizer: 研究会 分子を使った寄せ木細工
  • Place of Presentation: 島根大学松江キャンパス
  • Invited
• [Presentation] Correlation between thermo-responsiveness and primary structure of synthetic amphiphilic polymers (2016)
  • Author(s): Yukiteru Katsumoto
  • Organizer: Workshop on smart polymers
  • Place of Presentation: 北京森林大学(中国)
  • Int'l Joint Research / Invited
• [Presentation] 両親媒性マルチブロック共重合体のミセル化 (2016)
  • Author(s): Yukiteru Katsumoto
  • Organizer: The 10th Mini-Symposium on Liquids
  • Place of Presentation: 岡山大学理学部大会議室
  • Invited
• [Presentation] Impact of the Primary Structure on the Phase Behavior of Amphiphilic Polymers in Water (2016)
  • Author(s): Yukiteru Katsumoto
  • Organizer: 第２１回九州溶液化学懇談会
  • Place of Presentation: 福岡大学理学部
  • Int'l Joint Research / Invited
• [Presentation] 水溶液中におけるPoly(2-isopropyl-2-oxazoline)の感熱応答挙動とそのヒステリシス (2015)
  • Author(s): 勝本之晶
  • Organizer: 第64回高分子討論会
  • Place of Presentation: 東北大学川内キャンパス
  • Year and Date: 2015-09-15
• [Presentation] PNiPAmの感熱応答性に現れるヒステリシスの立体制御度依存性 (2015)
  • Author(s): 濵村健人，勝本之晶
  • Organizer: 第64回高分子討論会
  • Place of Presentation: 東北大学 川内キャンパス
  • Year and Date: 2015-09-15
• [Presentation] Hysteresis in the phase change of the stereo-controlled PNiPAm in water (2015)
  • Author(s): Kento Hamamura, Yukiteru Katsumoto
  • Organizer: Univ. of Ulsan – Fukuoka Univ. Joint Seminar
  • Place of Presentation: 福岡大学
  • Year and Date: 2015-08-19
  • Int'l Joint Research
• [Presentation] 立体制御されたPNiPAm水溶液の熱誘起相分離におけるヒステリシス (2015)
  • Author(s): 濵村健人，勝本之晶
  • Organizer: 第64回高分子学会年次大会
  • Place of Presentation: 札幌コンベンションセンター
  • Year and Date: 2015-05-27
• [Presentation] 水溶液中におけるウシ血清アルブミンとPEO-PPOマルチブロックコポリマーの会合挙動 (2015)
  • Author(s): 力山和晃，勝本之晶
  • Organizer: 第64回高分子年次大会
  • Place of Presentation: 札幌コンベンションセンター
  • Year and Date: 2015-05-27
• [Presentation] 水溶液中における熱応答性PEO-PPOマルチブロックコポリマーの凝集過程 (2015)
  • Author(s): 堀内 輔，近藤 真司，酒井 崇匡，勝本 之晶
  • Organizer: 第64回高分子学会年次大会
  • Place of Presentation: 札幌コンベンションセンター
  • Year and Date: 2015-05-27
• [Presentation] 高分子水溶液の相分離に対する分子構造論的アプローチ (2015)
  • Author(s): 勝本之晶
  • Organizer: 岡山大学理学部学術講演会
  • Place of Presentation: 岡山大学
  • Year and Date: 2015-03-13
  • Invited
• [Presentation] Physical background of the blue shift in the CH stretching band of alcohol in water (2015)
  • Author(s): Yukiteru KATSUMOTO
  • Organizer: Pure and Applied Chemistry International Conference 2015
  • Place of Presentation: Amari Watergate Hotel, Bangkok, Thailand
  • Year and Date: 2015-01-21 – 2015-01-23
  • Invited
• [Presentation] 蛍光プローブ法による立体制御されたアクリルアミド系高分子の水和状態の研究 (2014)
  • Author(s): 勝本之晶
  • Organizer: 第37回溶液化学シンポジウム
  • Place of Presentation: 佐賀県佐賀市アバンセ
  • Year and Date: 2014-11-12 – 2014-11-14
• [Presentation] 赤外分光法を用いて調べる溶液中における高分子鎖の局所構造と溶媒和 (2014)
  • Author(s): 勝本之晶
  • Organizer: 第63回高分子討論会
  • Place of Presentation: 長崎大学
  • Year and Date: 2014-09-24 – 2014-09-26
• [Presentation] Relationship between the local structure and thermo-responsiveness of polymer solutions (2014)
  • Author(s): Yukiteru KATSUMOTO
  • Organizer: International Meeting on Applications of Statistical Mechanics of Molecular Liuid on Soft Matter
  • Place of Presentation: Kasesart University, Bangkok, Thailand
  • Year and Date: 2014-09-14 – 2014-09-15
  • Invited
• [Presentation] How the interamolecular interaction affects the thermoresponsiveness of the acryl amide polymers (2014)
  • Author(s): Yukiteru KATSUMOTO
  • Organizer: Kathmandu Symposia on Advanced Materials 2014
  • Place of Presentation: The Everest Hotel (Napal)
  • Year and Date: 2014-09-07 – 2014-09-10
  • Invited
• [Presentation] Impact of the intermolecular interaction on the thermoresponsiveness of the acrylamide polymers (2014)
  • Author(s): Yukiteru KATSUMOTO
  • Organizer: ダッカ大学特別セミナー
  • Place of Presentation: University of Dhaka, Dhaka, Bangladesh
  • Year and Date: 2014-09-04 – 2014-09-06
  • Invited
• [Presentation] 分子性溶液の赤外スペクトルとシミュレーション (2014)
  • Author(s): 勝本之晶
  • Organizer: 九重分光学関連夏期セミナー
  • Place of Presentation: 九州地区国立大学九重共同研修所
  • Year and Date: 2014-07-25 – 2014-07-26
  • Invited
• [Book] エッセンシャル化学 (2015)
  • Author(s): 尾崎 幸洋, 勝本 之晶, 森田 成昭, 山本 茂樹, 森澤 勇介, 佐藤 春実
  • Total Pages: 195
  • Publisher: 培風館