| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
High performance / highly selective hydrophilic interaction (HILIC) type, ion exchange type, chiral separation type HPLC columns were prepared for monolithic and particle-packed type. They provided highly hydrophilic nature exceeding the performance limit of commercially available HILIC columns. (1) The relationship between the reaction conditions of the polymerization for surface modification of silica and the corresponding performance of the column were carefully examined to establish optimal modification conditions. (2) The correlation between the chain length of the introduced polymer chains and the separation performance and characteristics were examined. (3) HILIC type columns providing theoretical plate height 4-10 microns, 300,000 theoretical plates were prepared and applied to metabolome analysis. (4) A column having all of HILIC, cation exchange, anion exchange and chiral separation ability was prepared.
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