| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Outline of Final Research Achievements |
As a series of polyethylene glycol (PEG) analogues with structured macrocyclic morphology, PEGs with digonal to hexagonal structures were synthesized and their properties were evaluated. At room temperature, the macrocyclic PEG analogues showed higher hydrophobicity than the corresponding linear PEGs, and the hydrophobicity continuously increased with the ring size. At 70 °C, on the other hand, a topological effect was observed in the relationship between the molecular structure and hydrophobicity.
Amphiphilic PEGs bearing phenyl group at the end of PEG with different chain length were also developed. Phenyl octaethylene glycol showed higher protein aggregation suppression effect than phenyl tetraethylene glycol.
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