Identification of biological activities mediated by GPCR in dynamic equilibrium state of monomer and dimer
| Project/Area Number |
26410182
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Bio-related chemistry
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| Research Institution | Saga University |
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Principal Investigator |
KODAMA HIROAKI 佐賀大学, 工学(系)研究科(研究院), 教授 (80205418)
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| Co-Investigator(Kenkyū-buntansha) |
長田 聡史 佐賀大学, 工学(系)研究科(研究院), 准教授 (50284609)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | シグナル伝達 / GPCR / 二量体 / ペプチド合成 / 活性酸素 / 生体分子 / 生理活性 / 二量体ペプチド |
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| Outline of Final Research Achievements |
Many GTP coupled receptors exits as homodetic and heterodetic dimeric forms on the biological membrane and the functions of two protomers of dimeric GPCR have not been elucidated. To understand the functions of protomers of formyl peptide receptors, heterodetic dimeric peptides of peptides with the high selectivities for two receptor subtypes were synthesized. From the results of biological assays, dimeric peptides interact with the two protomers.
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Report
(4 results)
Research Products
(41 results)
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[Journal Article] Coadministration of the FNIII14 peptide synergistically augments the anti-cancer activity of chemotherapeutic drugs by activating pro-apoptotic Bim2016
Author(s)
T. Iyoda, Y. Nagamine, Y. Nakane, Y. Tokita, S. Akari, K. Otsuka, M. Fujita, K. Itagaki, Y. Takizawa, H. Orita, T. Owaki, J. Taira, R. Hayashi, H. Kodama, F. Fukai
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Journal Title
PLoS One
Volume: 11
Issue: 9
Pages: e0162525-e0162525
DOI
Related Report
Peer Reviewed / Open Access
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