| Project/Area Number |
26410186
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Bio-related chemistry
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| Research Institution | Yokohama College of Pharmacy |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
梶原 康宏 横浜薬科大学, 薬学部, 准教授 (50460283)
川嶋 剛 横浜薬科大学, 薬学部, 准教授 (60460284)
新谷 彰教 横浜薬科大学, 薬学部, 講師 (20588157)
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| Co-Investigator(Renkei-kenkyūsha) |
HIGASHIMOTO Yuichiro 久留米大学, 医学部, 教授 (40352124)
SATO Hideaki 久留米大学, 医学部, 准教授 (60271996)
SUGISHIMA Masakazu 久留米大学, 医学部, 准教授 (30379292)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | ポルフィリン生合成 / ポルフィリン症 / ウロポルフィリノーゲンIII合成酵素 / ヒドロキシメチルビラン合成酵素 / ハイドロキシメチルビラン合成酵素 / ヘムタンパク質 / ポルホビリノーゲン |
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| Outline of Final Research Achievements |
Heme contained in hemoglobin and others is an essential substance for most organisms. In the case of human, defect in its biosynthetic pathway enzyme causes a disease called porphyria. The patients of porphyria can not get outdoors on daytime in some cases due the increased light sensitivity that is general symptom of porphyria. In order to contribute to the drug discovery for porphyria and the treatment of patients, a detailed reaction mechanism of enzymes involved in heme biosynthesis was studied by using chemically synthesized analogs of substrate and slightly modified enzymes of function.
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