Development of water-soluble Zinc porphyrin aimed at Theranostics
| Project/Area Number |
26410189
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Bio-related chemistry
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| Research Institution | Ube National College of Technology |
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Principal Investigator |
HIROHARA SHIHO 宇部工業高等専門学校, 物質工学科, 教授 (70413804)
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| Co-Investigator(Renkei-kenkyūsha) |
OBATA Makoto 山梨大学, 総合研究部, 准教授 (70343267)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | ポルフィリン亜鉛錯体 / がん診断法(PET) / がん治療法(PDT) / グルコース鎖 / メルカプトエタノール鎖 / Theranostics / がん治療（PDT） / がん診断（PDD） / セラノスティクス / 光細胞毒性試験 / ポルフィリン / 腫瘍集積性置換基 / 腫瘍集積時間促進置換基 / がん治療(PDT) / がん診断(PET) / Theragnosis / PET / PDT / ポルフィリン誘導体 / 糖鎖 |
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| Outline of Final Research Achievements |
We synthesized [65Zn] or [Zn]-5,10,15,20-tetrakis(pentafluorophenyl)porphyrins ([65Zn]-P or Zn-P) bearing two kinds of substituent groups (G2M2), namely glucose group (denoted as G) and 2-mercaptoethanol group (denoted as M) as theranostics drug. The in vitro photocytotoxicity of Zn-PG2M2 was evaluated in HeLa human cervical cell line, RGK gastric carcinoma mucosal cell line, and two human glioblastoma cell lines (U87 and T98G). Zn-PG2M2 exerted the higher photocytotoxicity than fully glucosylated TFPP (G4) at 8 h incubation. From the pharmacokinetics study, the accumulation rate of [65Zn]-PG2M2 in the tumor was about the same as that in digestive organs at 24 h after intraperitoneal injection.
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Report
(4 results)
Research Products
(34 results)
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[Journal Article] Synthesis, Photophysical Properties, and Biological Evaluation of trans-Bisthioglycosylated Tetrakis(fluorophenyl)chlorin for Photodynamic Therapy2015
Author(s)
S. Hirohara, C. Oka, M. Totani, M. Obata, J. Yuasa, H. Ito, M. Tamura, H. Matsui, K. Kakiuchi, T. Kawai, M. Kawaichi, M. Tanihara
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Journal Title
J. Med. Chem.
Volume: 58
Issue: 21
Pages: 8658-8670
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Synthesis and PDT Effect of Polysaccharide-conjugated Porphyrins2014
Author(s)
Shiho Hirohara, Kohei Sharyo, Makoto Obata, Hayato Akahoshi, Masahiro Shiraishi, Kyosuke Fujitsu, Naoto Akiyama, Kenji Sugimoto, Kenji, Yoichi Nakano, Masato Tamura, Hirofumi Matsui and Masao Tanihara
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Journal Title
ALA-Porphyrin Science
Volume: 3(1)
Pages: 11-21
NAID
Related Report
Peer Reviewed / Acknowledgement Compliant
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