Development of PLLA porous nanofiber scaffold for tissue regeneration by using electrospinning method
| Project/Area Number |
26420027
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Materials/Mechanics of materials
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| Research Institution | Doshisha University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
森田 有亮 同志社大学, 生命医科学部, 教授 (80368141)
田中 和人 同志社大学, 生命医科学部, 教授 (50303855)
仲町 英治 同志社大学, 生命医科学部, 教授 (60099893)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 組織再生 / ファイバースキャホールド / 多孔質中空構造 / ポリ乳酸 / エレクトロスピニング / 栄養供給 / 有孔中空構造 / ポーラス構造 / 軟骨再生 / 中空構造 |
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| Outline of Final Research Achievements |
In this study, PLLA porous hollow fiber scaffold was developed by using electrospinning to maintain nutrient supply in cultured cartilage. Porous hollow fiber scaffold was fabricated by using the co-axial spinneret. PLLA/PEO solution as the outer solution was prepared by dissolving poly-L-lactic acid (PLLA) and polyethylene oxide (PEO) in 1,3-dioxolane. 40% ethanol was used as the inner solution. According to SEM observation, the fabricated fiber had porous hollow structure. According to fluorescent observation of diffusion of fluorescent solution through the fiber, the developed PLLA porous hollow fiber scaffold had an interconnected structure to maintain supply of a culture medium in cultured cartilage.
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Report
(4 results)
Research Products
(4 results)
