Development and verification of numerical simulation for microbubble-enhanced high-intensity focused ultrasound therapy
| Project/Area Number |
26420125
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Fluid engineering
|
|---|
| Research Institution | Nihon University |
|---|
Principal Investigator |
OKITA Kohei 日本大学, 生産工学部, 准教授 (20401135)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
YOSHINAKA Kiyoshi 産業技術総合研究所, 健康工学研究部門, 研究員 (90358341)
AZUMA Takashi 東京大学, 医学系研究科, 教授 (90421932)
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
|---|
| Keywords | キャビテーション / マイクロバブル / 超音波 / シミュレーション / 医用工学 |
|---|
| Outline of Final Research Achievements |
The efficient tissue ablation by controlling the inertial cavitation has been desired for the reduction of treatment time in current high-intensity focused ultrasound (HIFU) therapy. In the present study, the numerical simulator treating cavitation/microbubble in the ultrasound field has been developed. The simulator takes into account the heat generation due to oscillating cavitation bubbles as well as the rectified diffusion which has important role in the initial stage of cavitation bubble growth. The influences of various parameters of ultrasound on the inception of cavitation was investigated. And, the enhancement of localised heating in the cavitation-enhanced HIFU therapy was demonstrated by the present numerical simulation. Furthermore, validation data for the numerical simulation was obtained experimentally and was compared with the calculation result.
|
Report
(4 results)
Research Products
(15 results)
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] INFLUENCE OF BREAST STRUCTURE ON HIFU FOCAL ERROR2015
Author(s)
Kohei Okita, Mika Seki, Ryuta Narumi, Takashi Azuma, Junichi Shidooka, Hidemi Furusawa, Shu Takagi, Yoichiro Matsumoto
Organizer
15th International Symposium on Therapeutic Ultrasound
Place of Presentation
Utrecht, Netherlands
Year and Date
2015-04-15 – 2015-04-18
Related Report
-
-
