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Development and verification of numerical simulation for microbubble-enhanced high-intensity focused ultrasound therapy

Research Project

Project/Area Number 26420125
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Fluid engineering
Research InstitutionNihon University

Principal Investigator

OKITA Kohei  日本大学, 生産工学部, 准教授 (20401135)

Co-Investigator(Renkei-kenkyūsha) YOSHINAKA Kiyoshi  産業技術総合研究所, 健康工学研究部門, 研究員 (90358341)
AZUMA Takashi  東京大学, 医学系研究科, 教授 (90421932)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywordsキャビテーション / マイクロバブル / 超音波 / シミュレーション / 医用工学
Outline of Final Research Achievements

The efficient tissue ablation by controlling the inertial cavitation has been desired for the reduction of treatment time in current high-intensity focused ultrasound (HIFU) therapy. In the present study, the numerical simulator treating cavitation/microbubble in the ultrasound field has been developed. The simulator takes into account the heat generation due to oscillating cavitation bubbles as well as the rectified diffusion which has important role in the initial stage of cavitation bubble growth. The influences of various parameters of ultrasound on the inception of cavitation was investigated. And, the enhancement of localised heating in the cavitation-enhanced HIFU therapy was demonstrated by the present numerical simulation. Furthermore, validation data for the numerical simulation was obtained experimentally and was compared with the calculation result.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (15 results)

All 2017 2016 2015 2014 Other

All Journal Article (3 results) (of which Acknowledgement Compliant: 1 results,  Peer Reviewed: 1 results) Presentation (11 results) (of which Int'l Joint Research: 5 results,  Invited: 4 results) Remarks (1 results)

  • [Journal Article] 超音波によるバブルリポソームの制御に関するシミュレーション手法の開発2017

    • Author(s)
      速水尚,伊井仁志,沖田浩平,高木周
    • Journal Title

      ながれ

      Volume: 36(2)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Numerical Study on the Effective Heating due to Inertial Cavitation in Microbubbl-enhanced HIFU Therapy2015

    • Author(s)
      Kohei Okita, Kazuyasu Sugiyama, Shu Takagi, Yoichiro Matsumoto
    • Journal Title

      AIP Conf. Proc.

      Volume: 1685 Pages: 040021-040021

    • DOI

      10.1063/1.4934416

    • Related Report
      2015 Research-status Report
    • Acknowledgement Compliant
  • [Journal Article] The role of numerical simulation for the development of an advanced HIFU system2014

    • Author(s)
      Kohei Okita, Ryuta Narumi, Takashi Azuma, Shu Takagi, Yoichiro Matumoto
    • Journal Title

      Computational Mechanics

      Volume: 54 Issue: 4 Pages: 1023-1033

    • DOI

      10.1007/s00466-014-1036-y

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] Numerical Simulation of Cavitation-enhanced HIFU Therapy2017

    • Author(s)
      K. Okita, S. Takagi, Y. Matsumoto
    • Organizer
      IACM 19th International Conference on Finite Elements in Flow Problems (FEF2017)
    • Place of Presentation
      Rome, Italy
    • Year and Date
      2017-04-05
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 超音波によるバブルリポソームの制御に関するシミュレーション手法の開発2016

    • Author(s)
      速水 尚,伊井仁志,沖田浩平,高木 周
    • Organizer
      第30回数値流体力学シンポジウム
    • Place of Presentation
      江東区,東京
    • Year and Date
      2016-12-12
    • Related Report
      2016 Annual Research Report
  • [Presentation] Numerical study on cavitation-enhanced thermal and mechanical effects in high-intensity focused ultrasound therapy2016

    • Author(s)
      K. Okita, Y. Matsumoto
    • Organizer
      5th Joint Meeting of the Acoustical Society of America and the Acoustical Society of Japan
    • Place of Presentation
      Waikiki, Hawaii
    • Year and Date
      2016-11-28
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Cavitation-enhanced diagnostics and therapy in HIFU treatment2016

    • Author(s)
      Y. Matsumoto, K. Okita
    • Organizer
      5th Joint Meeting of the Acoustical Society of America and the Acoustical Society of Japan
    • Place of Presentation
      Waikiki, Hawaii
    • Year and Date
      2016-11-28
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 超音波によるバブルリポソームの制御に関する数値解析2016

    • Author(s)
      速水 尚,伊井仁志,沖田浩平,高木 周
    • Organizer
      混相流シンポジウム2016
    • Place of Presentation
      上京区,京都
    • Year and Date
      2016-08-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] Numerical Simulation for Development of Advanced HIFU Therapy2016

    • Author(s)
      Kohei Okita, Takashi Azuma, Shu Takagi, Yoichiro Matsumoto
    • Organizer
      The Joint Symposium of 10th International Symposium on Medical, Bio- and Nano-Electronics
    • Place of Presentation
      東北大学(宮城県,仙台市)
    • Year and Date
      2016-03-01
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] HIFU phase control simulation based on patient medical image with temperature dependency of sound speed during heating2016

    • Author(s)
      張 明禛,東 隆,沖田浩平,高木 周,松本洋一郎
    • Organizer
      第15回日本超音波治療研究会(JSTU2016)
    • Place of Presentation
      新宿区,東京
    • Related Report
      2016 Annual Research Report
  • [Presentation] Temperature distribution analysis for High Intensity Focused Ultrasound Breast Cancer Treatment by Numerical Simulation2015

    • Author(s)
      Mingzhen Zhang, Takashi Azuma, Xiaolei Qu, Ryuta Narumi, Shu Takagi, Yoichiro Matusmoto, Kohei Okita, Hidemi Furusaswa, Junichi Shidooka
    • Organizer
      2015 IEEE International Ultrasonic Symposium
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2015-10-21
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Numerical study on the effective heating due to inertial cavitation in microbubble-enhanced HIFU therapy2015

    • Author(s)
      Kohei Okita, Kazuyasu Sugiyama, Shu Takagi, Yoichiro Matsumoto
    • Organizer
      20th International Symposium on Nonlinear Acoustics
    • Place of Presentation
      Lyon, France
    • Year and Date
      2015-06-29 – 2015-07-03
    • Related Report
      2014 Research-status Report
  • [Presentation] INFLUENCE OF BREAST STRUCTURE ON HIFU FOCAL ERROR2015

    • Author(s)
      Kohei Okita, Mika Seki, Ryuta Narumi, Takashi Azuma, Junichi Shidooka, Hidemi Furusawa, Shu Takagi, Yoichiro Matsumoto
    • Organizer
      15th International Symposium on Therapeutic Ultrasound
    • Place of Presentation
      Utrecht, Netherlands
    • Year and Date
      2015-04-15 – 2015-04-18
    • Related Report
      2014 Research-status Report
  • [Presentation] NUMERICAL SIMULATION OF HIGH-INTENSITY FOCUSED ULTRAOUND TREATMENT FOR BREAST CANCER2014

    • Author(s)
      Kohei Okita, Ryuta Narumi, Takashi Azuma, Shu Takagi, Yoichiro Matsumoto
    • Organizer
      11th World Congress on Computational Mechanics (WCCM XI)
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2014-07-20 – 2014-07-25
    • Related Report
      2014 Research-status Report
  • [Remarks] Fluid Engineering Lab.

    • URL

      http://www.me.cit.nihon-u.ac.jp/lab/okita/

    • Related Report
      2016 Annual Research Report

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Published: 2014-04-04   Modified: 2018-03-22  

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