Radiation of electromagnetic wave by dispersive nonlienar pulse formation line for cancer treatment method by ultra-short pulse high electric field and its effect
| Project/Area Number |
26420220
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Power engineering/Power conversion/Electric machinery
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| Research Institution | Yamagata University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 非線形伝送線路 / 磁気スイッチ / バーストパルス / がん治療 / アポトーシス / がん細胞 / パルスパワー / パルス電磁波 |
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| Outline of Final Research Achievements |
The cancer treatment by an ultra-short pulse high electric field is one of new biological applications. It is shown that cancer is able to be treated by nanosecond pulsed high electric field. This work focuses on the development of a high power nanosecond pulsed electromagnetic wave generator for the cancer treatment and effect on cancer cells by the developed apparatus. We have developed a pulsed power generator that outputs the multiple pulses continuously by a NLTL (Nonlinear Transmission Line) using magnetic switches. The NLTL makes the pulse train by delaying the propagation of the pulse through the magnetic switch of each ladder. In this study, we have carried out optimization of the transmission line and higher frequency. In addition, high power burst pulses made by the developed apparatus up to 5 ladder stages have been applied to the cancer cells. Here, we have used HeLa-S3 that is subspecies of human cervical cancer as the cancer cell.
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Report
(4 results)
Research Products
(12 results)
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[Presentation] Expression of proteins controlling apoptosis in a cell applying high frequency burst pulse high electric field2016
Author(s)
Yasushi Minamitani, Yoshie Kuramochi, Takashi Toyooka, Kazuki Shinagawa, Kenji Tamura, Riku Kageyama, Yuta Kobayashi, Kazunori Mitsutake, Misako Yano, Masaya Morotomi, Sunao Katsuki, Hidenori Akiyama
Organizer
The 3rd Taiwan-Japan Workshop on Plasma Life Science and Technology
Place of Presentation
New Taipei City (Taiwan)
Year and Date
2016-12-17
Related Report
Int'l Joint Research / Invited
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