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3-D analysis of light propagation in biomedical object using voxel-level photon fluence and detection of skin diseases

Research Project

Project/Area Number 26420379
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Measurement engineering
Research InstitutionMuroran Institute of Technology

Principal Investigator

AIZU Yoshihisa  室蘭工業大学, 工学研究科, 教授 (20212350)

Co-Investigator(Kenkyū-buntansha) 島谷 祐一  東京都市大学, 工学部, 准教授 (20154263)
Co-Investigator(Renkei-kenkyūsha) YUASA Tomonori  室蘭工業大学, 工学研究科, 准教授 (60241410)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords分光反射率 / 皮膚計測 / ハイパースペクトル / イメージング / 光子フルーエンス / 生体光吸収 / 生体光散乱
Outline of Final Research Achievements

We studied to develop a total imaging system for skin tissue, in which hyper-spectral images are acquired, simulated reflectance spectrum is fitted to measured spectrum in the 9-layered Monte Calro skin model, absorption and scattering coefficients are estimated for each of nine layres, and 3-D photon fluence distribution is obtained. In this study, especially, the photon fluence based on the reflected component only is treated to reconstruct the skin surface image with possibly realistic color. This may be useful for comparison with clinical skin images or visual observation by a medical doctor.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (37 results)

All 2016 2015 2014

All Journal Article (13 results) (of which Peer Reviewed: 13 results,  Acknowledgement Compliant: 11 results) Presentation (24 results) (of which Int'l Joint Research: 8 results,  Invited: 3 results)

  • [Journal Article] Estimation of spectral transmittance curves from RGB images in color digital holographic microscopy using speckle illuminations2016

    • Author(s)
      Hideki Funamizu, Yuta Tokuno, and Yoshihisa Aizu
    • Journal Title

      Optical Review

      Volume: 印刷中 Issue: 3 Pages: 535-543

    • DOI

      10.1007/s10043-016-0180-3

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of blood flow covering a wide region of velocity in laser speckle image sensing2016

    • Author(s)
      N. Yokoi and Y. Aizu
    • Journal Title

      Measurement

      Volume: 91 Pages: 342-350

    • DOI

      10.1016/j.measurement.2016.05.066

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Probing depth and dynamic response of speckles in near infrared region for spectroscopic blood flow imaging2016

    • Author(s)
      Naomichi Yokoi, Yoshihisa Aizu
    • Journal Title

      Optics & Laser Technology

      Volume: 78 Part B Pages: 106-114

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Measurements of size and absorption coefficient of a single moving particle by using dual burst Doppler signal2015

    • Author(s)
      Naomichi Yokoi, Yoshihisa Aizu
    • Journal Title

      Measurement

      Volume: 59 Pages: 51-62

    • DOI

      10.1016/j.measurement.2014.09.040

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Improvement of estimation parameter for frame-rate analysis of blood flow using laser speckle image sensing2014

    • Author(s)
      Naomichi Yokoi, Takaaki Maeda, Yuichi Shimatani, Hideki Funamizu, and Yoshihisa Aizu
    • Journal Title

      Optics and Lasers in Engineering

      Volume: 52 Pages: 156-166

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Color digital holography using speckle illumination by means of multi-mode fiber2014

    • Author(s)
      H. Funamizu, S. Shimoma and Y. Aizu
    • Journal Title

      Optics Communications

      Volume: 312 Pages: 245-251

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Development of non-deterioration-type skin tissue phantom using silicone material2014

    • Author(s)
      Saidatul Iva, Akihiro Tanabe, Takaaki Maeda, Hideki Funamizu, Yoshihisa Aizu
    • Journal Title

      OPTICAL REVIEW

      Volume: 21 Pages: 353-358

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Frame-rate analysis of arterial blood flow in human and rat using laser speckle image sensing2014

    • Author(s)
      Naomichi Yokoi, Junki Sato, Yuichi Shimatani, Masaki Kyoso, Hideki Funamizu, Yoshihisa Aizu
    • Journal Title

      OPTICAL REVIEW

      Volume: 21 Pages: 345-352

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Simulation of Spectral Reflectances in Human Skin Tissue Using Ray Tracing and GPU-Based Monte Carlo Method2014

    • Author(s)
      Hideki Funamizu, Takaaki Maeda, Shoko Sasaki, Izumi Nishidate, Yoshihisa Aizu
    • Journal Title

      OPTICAL REVIEW

      Volume: 21 Pages: 359-363

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Color Adjustment Algorithm Adapted to the Spectral Reflectance Estimation Method2014

    • Author(s)
      Tomonori Yuasa, Ryosuke Honma, Hideki Funamizu, Izumi Nishidate, Yoshihisa Aizu
    • Journal Title

      OPTICAL REVIEW

      Volume: 21 Pages: 369-372

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Imaging of blood flow and blood concentration change in a frame rate using laser speckle: Methods for image analysis2014

    • Author(s)
      Naomichi Yokoi, Yuichi Shimatani, Masaki Kyoso, Hideki Funamizu, Yoshihisa Aizu
    • Journal Title

      Optics & Laser Technology

      Volume: 64 Pages: 352-362

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 生体内光伝搬におけるランダムネス:理解と応用2014

    • Author(s)
      相津佳永
    • Journal Title

      光学

      Volume: 43 Pages: 202-210

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Effects of spatiotemporal averaging processes on the estimation of spectral reflectance in color digital holography using speckle illuminations2014

    • Author(s)
      Hideki Funamizu, Shohei Shimoma, Tomonori Yuasa, and Yoshihisa Aizu
    • Journal Title

      Applied Optics

      Volume: 53 Pages: 7072-7080

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Color Digital Holographic Microscopy Using Speckle Illuminations for Removing Twin Image2016

    • Author(s)
      H. Funamizu, T.Q. Chen, Y. Aizu
    • Organizer
      Biomedical Imaging and Sensing Conference 2016
    • Place of Presentation
      Pacifico Yokohama, Yokohama, Kanagawa, Japan
    • Year and Date
      2016-05-18
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Simulation of Spectral Reflectance Image in Human Skin Model Having a Measured Surface Texture by Ray Tracing2016

    • Author(s)
      T. Yuasa, K. Mizunuma, R. Goto, T. Maeda, H. Funamizu, Y. Aizu
    • Organizer
      Biomedical Imaging and Sensing Conference 2016
    • Place of Presentation
      Pacifico Yokohama, Yokohama, Kanagawa, Japan
    • Year and Date
      2016-05-18
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Estimation of Stress Condition Based on Autonomic Nervous Function by Bio-Speckle Imaging2016

    • Author(s)
      N. Yokoi, Y. Shimatani, M. Kyoso, H. Funamizu, Y. Aizu
    • Organizer
      Biomedical Imaging and Sensing Conference 2016
    • Place of Presentation
      Pacifico Yokohama, Yokohama, Kanagawa, Japan
    • Year and Date
      2016-05-18
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Simultaneous Imaging of Blood Flow and Blood Concentration Change Using Laser Speckle in Fiber Illumination2016

    • Author(s)
      T. Shinohara, N. Yokoi, H. Funamizu, T. Yuasa, Y. Aizu
    • Organizer
      Biomedical Imaging and Sensing Conference 2016
    • Place of Presentation
      Pacifico Yokohama, Yokohama, Kanagawa, Japan
    • Year and Date
      2016-05-18
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Fundamental Study on Control of Motion of Nanoparticles Using Scattering Field of Laser Light2015

    • Author(s)
      Naomichi Yokoi, Yoshihisa Aizu
    • Organizer
      The 5th Asian and Pacific-Rim Symposium on Biophotonics
    • Place of Presentation
      Pacifico Yokohama, Yokohama, Kanagawa, Japan
    • Year and Date
      2015-04-22
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Dynamic observation of blood coagulation process in digital holographic microscopy2015

    • Author(s)
      Hideki FUNAMIZU, Yuki WATANABE, Taishi KUMAGAI and Yoshihisa AIZU
    • Organizer
      The 5th Asian and Pacific-Rim Symposium on Biophotonics
    • Place of Presentation
      Pacifico Yokohama, Yokohama, Kanagawa, Japan
    • Year and Date
      2015-04-22
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Simultaneous measurement of vasomotion and plethysmogram in human skin during Stroop test2015

    • Author(s)
      Akira Hoshi, Izumi Nishidate, Kyuichi Niizeki, and Yoshihisa Aizu
    • Organizer
      The 5th Asian and Pacific-Rim Symposium on Biophotonics
    • Place of Presentation
      Pacifico Yokohama, Yokohama, Kanagawa, Japan
    • Year and Date
      2015-04-22
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Non-contact imaging of plethysmogram and tissue oxygen saturation during change in fraction of inspired oxygen2015

    • Author(s)
      Ryota Sato, Izumi Nishidate, Kyuichi Niizeki, and Yoshihisa Aizu
    • Organizer
      The 5th Asian and Pacific-Rim Symposium on Biophotonics
    • Place of Presentation
      Pacifico Yokohama, Yokohama, Kanagawa, Japan
    • Year and Date
      2015-04-22
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 皮膚光計測のための多層構造皮膚モデルによる光子フルーエンス解析2015

    • Author(s)
      相津佳永,船水英希,横井直倫,湯浅友典
    • Organizer
      レーザー学会学術講演会第35回年次大会
    • Place of Presentation
      東京都品川区,東海大学品川キャンパス
    • Year and Date
      2015-01-11 – 2015-01-12
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] スペックル照明を用いたカラーディジタルホログラフィにおける分光反射率推定と画質改善2014

    • Author(s)
      船水英希、湯浅友典、相津佳永
    • Organizer
      第54回 光波センシグ技術研究会講演会
    • Place of Presentation
      東京都新宿区,東京理科大学神楽坂校舎
    • Year and Date
      2014-12-09 – 2014-12-10
    • Related Report
      2014 Research-status Report
  • [Presentation] レーザースペックル血流計測における測定深さの検討2014

    • Author(s)
      山崎 弦也,横井 直倫,船水 英希,相津 佳永
    • Organizer
      Optics & Photonics Japan 2014
    • Place of Presentation
      東京都文京区,筑波大学東京キャンパス文京校舎
    • Year and Date
      2014-11-05 – 2014-11-07
    • Related Report
      2014 Research-status Report
  • [Presentation] ディジタルホログラフィック顕微鏡を用いた血液凝固の動的イメージング2014

    • Author(s)
      渡辺 裕樹,熊谷 泰志,船水 英希,相津 佳永
    • Organizer
      Optics & Photonics Japan 2014
    • Place of Presentation
      東京都文京区,筑波大学東京キャンパス文京校舎
    • Year and Date
      2014-11-05 – 2014-11-07
    • Related Report
      2014 Research-status Report
  • [Presentation] 多層構造皮膚モデルにおける拡散反射光の空間分布解析2014

    • Author(s)
      稲垣 雄太,奥塚 太一,前田 貴章,船水 英希,相津 佳永
    • Organizer
      Optics & Photonics Japan 2014
    • Place of Presentation
      東京都文京区,筑波大学東京キャンパス文京校舎
    • Year and Date
      2014-11-05 – 2014-11-07
    • Related Report
      2014 Research-status Report
  • [Presentation] 非劣化型皮膚ファントムの分光反射率特性2014

    • Author(s)
      田辺 哲裕,前田 貴章,船水 英希,西館 泉,相津 佳永
    • Organizer
      Optics & Photonics Japan 2014
    • Place of Presentation
      東京都文京区,筑波大学東京キャンパス文京校舎
    • Year and Date
      2014-11-05 – 2014-11-07
    • Related Report
      2014 Research-status Report
  • [Presentation] 吸入酸素濃度変化における容積脈波と組織酸素飽和度の非接触イメージング―動物実験による検討2014

    • Author(s)
      佐藤 遼太,西舘 泉,新関 久一,相津 佳永
    • Organizer
      Optics & Photonics Japan 2014
    • Place of Presentation
      東京都文京区,筑波大学東京キャンパス文京校舎
    • Year and Date
      2014-11-05 – 2014-11-07
    • Related Report
      2014 Research-status Report
  • [Presentation] ストループテスト時における皮膚血管運動と容積脈波の同時イメージング2014

    • Author(s)
      星 輝,西舘 泉,新関 久一,相津 佳永
    • Organizer
      Optics & Photonics Japan 2014
    • Place of Presentation
      東京都文京区,筑波大学東京キャンパス文京校舎
    • Year and Date
      2014-11-05 – 2014-11-07
    • Related Report
      2014 Research-status Report
  • [Presentation] 光線追跡計算によるヒト皮膚モデルの分光反射率シミュレーション2014

    • Author(s)
      相津佳永
    • Organizer
      LightTools特別セミナー2014
    • Place of Presentation
      東京都千代田区,アキバホール
    • Year and Date
      2014-10-21
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] バイオスペックル血流イメージングにおける血流領域の深さ推定2014

    • Author(s)
      横井 直倫,相津 佳永
    • Organizer
      第75回応用物理学会秋季学術講演会
    • Place of Presentation
      札幌市,北海道大学
    • Year and Date
      2014-09-17 – 2014-09-20
    • Related Report
      2014 Research-status Report
  • [Presentation] Numerical considerations on measurements of lightabsorbing particles using polarized-type phase Doppler Method2014

    • Author(s)
      Naomichi YOKOI,Yoshihisa AIZU
    • Organizer
      10th Int. Conf. on Laser-light and Interactions with Particles
    • Place of Presentation
      Marseille, France
    • Year and Date
      2014-08-25 – 2014-08-29
    • Related Report
      2014 Research-status Report
  • [Presentation] Observation of red blood cells in bood coagulation using digital holographic microscopy2014

    • Author(s)
      Hideki FUNAMIZU,Yuki WATANABE,Yoshihisa AIZU
    • Organizer
      10th Int. Conf. on Laser-light and Interactions with Particles
    • Place of Presentation
      Marseille, France
    • Year and Date
      2014-08-25 – 2014-08-29
    • Related Report
      2014 Research-status Report
  • [Presentation] 可視・近赤外分光計測と光伝搬計算による皮膚組織イメージング2014

    • Author(s)
      相津 佳永
    • Organizer
      第9回レーザー学会「レーザーバイオ医療」技術専門委員会
    • Place of Presentation
      札幌市,北海道大学
    • Year and Date
      2014-06-06
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Observation of Aggregation Structure of Red Blood Cells in Blood Coagulation Using Digital Holographic Microscopy2014

    • Author(s)
      H. Funamizu, Y. Watanabe, Y. Aizu
    • Organizer
      Biomedical Imaging and Sensing Conference 14
    • Place of Presentation
      Pacifico Yokohama, Yokohama, Kanagawa, Japan
    • Year and Date
      2014-04-23 – 2014-04-25
    • Related Report
      2014 Research-status Report
  • [Presentation] Study on Depth Measurement of a Blood Flow Region Based on Speckle Correlation2014

    • Author(s)
      N. Yokoi,Y. Aizu
    • Organizer
      Biomedical Imaging and Sensing Conference 14
    • Place of Presentation
      Pacifico Yokohama, Yokohama, Kanagawa, Japan
    • Year and Date
      2014-04-23 – 2014-04-25
    • Related Report
      2014 Research-status Report
  • [Presentation] Noncontact Imaging of Human Skin Hemodynamics Using a Digital Red-green-blue Camera2014

    • Author(s)
      I. Nishidate, R. Matsuda, R. Sato, T. Maeda, T. Yuasa, K. Niizeki, Y. Aizu
    • Organizer
      Biomedical Imaging and Sensing Conference 14
    • Place of Presentation
      Pacifico Yokohama, Yokohama, Kanagawa, Japan
    • Year and Date
      2014-04-23 – 2014-04-25
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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