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Occurrence of endotoxin activity and its formation potential in water source and water for healthcare

Research Project

Project/Area Number 26420540
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Civil and environmental engineering
Research InstitutionNational Institute of Public Health

Principal Investigator

Simazaki Dai  国立保健医療科学院, 生活環境研究部水管理研究領域, 上席主任研究官 (60322046)

Co-Investigator(Kenkyū-buntansha) 秋葉 道宏  国立保健医療科学院, その他部局等, 統括研究官 (00159336)
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsエンドトキシン / 浄水処理 / 水道水 / 透析用水 / 浄水場 / 医療施設 / 医療用水 / 水道 / 従属栄養細菌
Outline of Final Research Achievements

Occurrence of residual endotoxin activity (ET) in tap water is a matter of great concern to medical professionals conducting dialysis therapy in healthcare facilities (HCFs). This study was performed to determine the occurrence and fate of the ET at selected Japanese drinking water purification plants and HCFs. Chemical coagulation and sedimentation, rapid sand filtration, and membrane filtration were highly effective to decrease ET. Moderate decreases in bound-ET and limited decreases in free-ET were observed by chlorination and ozonation. Bacterial activated carbon filtration was a major cause of significant increases in endotoxin activity during the course of drinking water purification process. Microbial regrowth on the premises, from water tanks to faucets at HCFs could also contribute to ET increases in tap water.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (13 results)

All 2018 2017 2016 2015 2014 Other

All Presentation (12 results) (of which Int'l Joint Research: 1 results) Remarks (1 results)

  • [Presentation] Fate of Endotoxic Activity in the course of Drinking Water Purification Process2018

    • Author(s)
      D. Simazaki, N. Utsuki, H. Sukegawa, T. Gushiken, and M. Akiba
    • Organizer
      IWA World Water Congress & Exhibition
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 国内の水道原水および水道水における硫酸塩の存在状況2017

    • Author(s)
      島﨑大,秋葉道宏
    • Organizer
      第62回日本透析医学会学術集会・総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2017-06-16
    • Related Report
      2016 Research-status Report
  • [Presentation] 水道の高度浄水処理におけるエンドトキシン活性の消長2017

    • Author(s)
      島﨑大,秋葉道宏
    • Organizer
      第76回日本公衆衛生学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 高度浄水処理工程におけるエンドトキシン活性の挙動に関する研究2016

    • Author(s)
      橋本久志,髙村光輝,渡部純也,島﨑大,秋葉道宏
    • Organizer
      第67回全国水道研究発表会
    • Place of Presentation
      みやこめっせ
    • Year and Date
      2016-11-09
    • Related Report
      2016 Research-status Report
  • [Presentation] 浄水処理工程および医療用水におけるエンドトキシン活性の存在状況と挙動2016

    • Author(s)
      島﨑大,秋葉道宏
    • Organizer
      第75回日本公衆衛生学会総会
    • Place of Presentation
      グランフロント大阪
    • Year and Date
      2016-10-26
    • Related Report
      2016 Research-status Report
  • [Presentation] 国内の水道原水および医療用水等におけるエンドトキシン活性の季節変化2016

    • Author(s)
      島﨑大,秋葉道宏
    • Organizer
      第61回日本透析医学会学術集会・総会
    • Place of Presentation
      リーガロイヤルNDB
    • Year and Date
      2016-06-10
    • Related Report
      2016 Research-status Report
  • [Presentation] 国内の水道原水および医療用水等におけるエンドトキシン活性の季節変化2016

    • Author(s)
      島﨑大,秋葉道宏
    • Organizer
      第61回日本透析医学会学術集会・総会
    • Place of Presentation
      リーガロイヤルNCB
    • Year and Date
      2016-06-10
    • Related Report
      2015 Research-status Report
  • [Presentation] 浄水処理の凝集沈澱・砂ろ過・塩素消毒過程におけるエンドトシキン活性の挙動2016

    • Author(s)
      島﨑大,三谷翔,三谷駿太,小沼晋,齋藤利晃,秋葉道宏
    • Organizer
      第50回日本水環境学会年会講演集
    • Place of Presentation
      アスティとくしま
    • Year and Date
      2016-03-16
    • Related Report
      2015 Research-status Report
  • [Presentation] 水道原水・処理工程水・医療用水におけるエンドトキシン活性の存在状況に関する研究2015

    • Author(s)
      廣瀬正晃,山中駿司,島﨑大,秋葉道宏
    • Organizer
      第66回全国水道研究発表会講演集
    • Place of Presentation
      さいたまスーパーアリーナ
    • Year and Date
      2015-10-21
    • Related Report
      2015 Research-status Report
  • [Presentation] 国内の水道原水・浄水処理工程・医療用水等におけるエンドトキシン活性の挙動2015

    • Author(s)
      島﨑大,秋葉道宏
    • Organizer
      第60回日本透析医学会学術集会・総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2015-06-28
    • Related Report
      2015 Research-status Report 2014 Research-status Report
  • [Presentation] 水道原水および浄水におけるエンドトシキンの存在状況ならびに塩素処理による挙動に関する研究2014

    • Author(s)
      島﨑大,井上宏隆,山田圭一,吉村友希,秋葉道宏
    • Organizer
      第65回全国水道研究発表会講演集
    • Place of Presentation
      ポートメッセ名古屋
    • Year and Date
      2014-10-29 – 2014-10-31
    • Related Report
      2014 Research-status Report
  • [Presentation] 国内の水道水ならびに水道原水におけるエンドトキシン活性値および生菌数の存在状況2014

    • Author(s)
      島﨑大,秋葉道宏
    • Organizer
      第59回日本透析医学会学術集会・総会
    • Place of Presentation
      クオリティホテル神戸
    • Year and Date
      2014-06-13 – 2014-06-15
    • Related Report
      2014 Research-status Report
  • [Remarks] 水道原水・医療用水中のエンドトキシン活性と生成能の存在状況に関する研究

    • URL

      https://www.niph.go.jp/soshiki/09seikatsu/shimazaki_j.pdf

    • Related Report
      2017 Annual Research Report 2016 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2019-03-29  

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