| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
In the present study, thermoresponsive cell separation materials were developed for the application in regenerative medicine. Thermoresponsive polymer, poly(N-isopropylacrylamide), was modified on glass plates, micro structured substrates, and microfibers. Various types of cells were seeded on the prepared substrates at 37℃, and detached at 20℃. Temperature-modulated cell separation was performed using the difference in cell adhesion property on the prepared substrates. Cell separation efficiency using the prepared substrates was improved by increasing the difference in cell adhesion property among cell types.
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