Development of anti-tumor-promoting reagent based on the safety assessment of fuel crop Jatropha curcas
| Project/Area Number |
26420801
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biofunction/Bioprocess
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| Research Institution | Kindai University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
柳原 格 地方独立行政法人大阪府立病院機構大阪母子医療センター(研究所), 免疫部門, 部長 (60314415)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | Jatropha curcas / phorbolester / anti-tumor promoter / phorbol ester / tumor promotion / anti tumor promoter / molecular probe |
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| Outline of Final Research Achievements |
Jatropha curcas is a tropical shrub which contains more than 50 %(w/w) liquid neutral lipid suitable for biodiesel production in its seeds and is expected as a raw crop for next generation biofuels. On the other hand, this plant produces phorbol esters having tumor promoting activity as a secondary metabolite other than lipids. In the process of evaluating the safety of this plant, we found that this plant also contains metabolites that act as the counteractant of PMA, which is known as a potent tumor promoter. In this study, we gained insights on the chemical properties and physiological activities of this anti-tumor promoting metabolite of this this plant.
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Report
(5 results)
Research Products
(3 results)
