Construction of a library of oral vaccine on malaria using molecular display
| Project/Area Number |
26420803
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biofunction/Bioprocess
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| Research Institution | Hyogo University of Health Sciences |
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Principal Investigator |
SHIBASAKI Seiji 兵庫医療大学, 共通教育センター, 准教授 (50342530)
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| Co-Investigator(Kenkyū-buntansha) |
岩崎 剛 兵庫医療大学, 薬学部, 教授 (10151721)
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| Research Collaborator |
SANO Hajime 兵庫医科大学, 医学部, 教授 (00196304)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 分子ディスプレイ / 酵母 / ワクチン / ディスプレイ / 提示 / 抗原 |
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| Outline of Final Research Achievements |
By using molecular display technology in yeast cells, a convenient method to develop oral vaccines such as malaria and other infectious diseases. A model proteins was efficiently displayed on the yeast cell surface. Kinds of host cells and anchoring protein were examined at first. Plasmids for creation of library , cultivate condition and preservative condition of yeast cell were also investigated.
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Report
(4 results)
Research Products
(9 results)
