| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Outline of Final Research Achievements |
Gaze holding is controlled primarily by neural structures including the prepositus hypoglossi nucleus (PHN) for the horizontal gaze and the interstitial nucleus of Cajal (INC) for the vertical gaze. In this study, to verify whether the neural structure of the INC is similar to that of the PHN, we compared the network properties between the INC and PHN. The application of burst stimulation induced an increase in the frequency of spontaneous excitatory postsynaptic current (EPSCs). The duration of the increased EPSC frequency of INC neurons was not significantly different from that of PHN neurons. The percent of duration reduction induced by a Ca2+-permeable AMPA receptors (CP-AMPA) antagonist was significantly smaller in the INC than in the PHN. These results suggest that the local excitatory networks that activated the sustained EPSCs are present both in the INC and PHN, but their activation mechanisms including the contribution of CP-AMPA are different between them.
|
