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Hippocampus-synthesized brain steroids are strong modulators of neuronal synapses and memory

Research Project

Project/Area Number 26430006
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurophysiology / General neuroscience
Research InstitutionJuntendo University (2015-2016)
The University of Tokyo (2014)

Principal Investigator

KAWATO Suguru  順天堂大学, 医学部, 客員教授 (50169736)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywords神経内分泌学 / 脳ステロイド / 海馬 / シナプス / 記憶 / 神経ステロイド
Outline of Final Research Achievements

Sex-steroids rapidly and non-genomically modulated the dendritic spines in the rat hippocampus. We analyzed the molecular mechanisms of these modulations by using 3-dimentional confocal microscopic imaging of neuronal synapses. Upon application of male hormones (T and DHT) and female hormones (E2 PROG) for 2 h, the density of dendritic spines were significantly increased. The signal pathways of these modulations were “binding of sex-steroids to their classic steroid receptors in spines → phosphorylation of kinases such as LIMK and MAPK → phosphorylation of cofilin and cortactin → actin polymerization → spine increase”. From electrophysiological investigations, nongenomic pathway of E2-induced long-term potentiation was also found.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (28 results)

All 2017 2016 2015 2014 Other

All Journal Article (10 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 8 results) Presentation (16 results) (of which Int'l Joint Research: 1 results,  Invited: 8 results) Remarks (2 results)

  • [Journal Article] LNCaP細胞の浸潤性に関与するアリール炭化水素受容体のシグナル伝達(Aryl hydrocarbon receptor signaling involved in the invasiveness of LNCaP cells)2017

    • Author(s)
      Ide H, Lu Y, Yu J, Kawato S, Horie S
    • Journal Title

      Human cell

      Volume: 30 Issue: 2 Pages: 133

    • DOI

      10.1007/s13577-016-0158-2

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 脳海馬で合成される男性・女性ホルモンは記憶力を増強する2016

    • Author(s)
      川戸 佳
    • Journal Title

      生化学

      Volume: 88 Pages: 342-353

    • NAID

      40020895223

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 海馬のテストステロン産生2016

    • Author(s)
      川戸 佳
    • Journal Title

      日本抗加齢医学会雑誌

      Volume: 12 Pages: 28-33

    • Related Report
      2016 Annual Research Report
  • [Journal Article] テストステロンと脳のアンチエイジング2016

    • Author(s)
      川戸 佳
    • Journal Title

      Medical Science Digest

      Volume: 42 Pages: 4-7

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Estradiol Rapidly Modulates Synaptic Plasticity of Hippocampal Neurons: Involvement of Kinase Networks2015

    • Author(s)
      Hasegawa Y, Hojo Y, Kojima H, Ikeda M, Hotta K, Sato R, Yoshiya M, Chung BC, Ooishi Y, and Kawato S
    • Journal Title

      Brain Res

      Volume: 1621 Pages: 147-161

    • DOI

      10.1016/j.brainres.2014.12.056

    • Related Report
      2015 Research-status Report 2014 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Rapid increase of spines by dihydrotestosterone and testosterone in hippocampal neurons2015

    • Author(s)
      Hatanaka Y, Hojo Y, Mukai H, Murakami G, Komatsuzaki Y, Kim J, Ikeda M, Hiragushi A, Kimoto T, and Kawato S
    • Journal Title

      Brain Res

      Volume: 1621 Pages: 121-132

    • DOI

      10.1016/j.brainres.2014.12.011

    • Related Report
      2015 Research-status Report 2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Estrogen Receptor KO Mice Study on Rapid Modulation of Spines and Long-term Depression in the Hippocampus2015

    • Author(s)
      Murakami G, Hojo Y, Ogiue-Ikeda M, Mukai H, Chambon P, Nakajima K, Ooishi Y, Kimoto T and Kawato S
    • Journal Title

      Brain Res

      Volume: 1621 Pages: 133-146

    • DOI

      10.1016/j.brainres.2014.12.002

    • Related Report
      2015 Research-status Report 2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Aging-induced changes in sex-steroidogenic enzymes and sex-steroid receptors in the cortex, hypothalamus and cerebellum2015

    • Author(s)
      Munetomo A, Hojo Y, Higo S, Kato A, Yoshida K, Shirasawa T, Shimizu T, Barron A, Kimoto T and Kawato S
    • Journal Title

      J Physiol. Sci

      Volume: 65 Issue: 3 Pages: 253-263

    • DOI

      10.1007/s12576-015-0363-x

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Estradiol Rapidly Modulates Spinogenesis in Hippocampal Dentate Gyrus: Involvement of Kinase Networks2015

    • Author(s)
      Hojo Y, Munetomo A, Mukai H, Ikeda M, Sato R, Hatanaka Y, Murakami G, Komatsuzaki Y, Kimoto T and Kawato S
    • Journal Title

      Hormones and Behavior

      Volume: 74 Pages: 149-156

    • DOI

      10.1016/j.yhbeh.2015.06.008

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Hippocampal spine change along the sleep-wake cycle: corticosterone and kinases2015

    • Author(s)
      Ikeda M, Hojo Y, Komatsuzaki Y, Okamoto M, Kato A, Takeda T and Kawato S
    • Journal Title

      J. Endocrinol

      Volume: 226 Issue: 2 Pages: M13-M27

    • DOI

      10.1530/joe-15-0078

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Presentation] テストステロンの中枢神経への作用2016

    • Author(s)
      川戸佳
    • Organizer
      第16回 抗加齢医学会総会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 脳内における性ホルモン作用、雄と雌の差2016

    • Author(s)
      川戸佳
    • Organizer
      第16回 Men's Health 医学会
    • Place of Presentation
      札幌医科大学記念ホール(北海道札幌市)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Modulation of Memory -related Synapses by Hippocampus-syntheized Estrogen and Androgen2016

    • Author(s)
      加藤麻紗実 北条泰嗣 川戸佳
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] Estrogen rapidly modulates spinogenesis in the hippocampus2016

    • Author(s)
      川戸佳
    • Organizer
      17th International Congress of Endocrinology
    • Place of Presentation
      北京市・中華人民共和国
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 男性ホルモンは脳でも創られる。やる気や認知度を支えている2016

    • Author(s)
      川戸佳
    • Organizer
      抗加齢内分泌研究会
    • Place of Presentation
      札幌プリンスホテル(北海道札幌市)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 性ホルモンによる海馬神経シナプスの制御:オスとメスの性差2016

    • Author(s)
      加藤麻紗実 川戸佳
    • Organizer
      第54回日本生物物理学年会
    • Place of Presentation
      つくば国際会議場(茨城県つくば市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] 脳海馬が作る男性・女性ホルモンは記憶神経を早く・うまく制御している2015

    • Author(s)
      川戸佳
    • Organizer
      生化学会
    • Place of Presentation
      神戸
    • Year and Date
      2015-11-04
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 海馬シナプスへの性ホルモンの急性作用:男性ホルモンと女性ホルモンの違い2015

    • Author(s)
      北條泰嗣, 長谷川賢卓, 畑中悠佑, 鍾邦柱, 川戸佳
    • Organizer
      生物物理学会
    • Place of Presentation
      金沢
    • Year and Date
      2015-09-14
    • Related Report
      2015 Research-status Report
  • [Presentation] 海馬で合成される男性・女性ホルモンによる記憶シナプスの急性制御の解析2015

    • Author(s)
      加藤麻紗実 北条泰嗣 川戸佳
    • Organizer
      生物物理学会
    • Place of Presentation
      金沢
    • Year and Date
      2015-09-14
    • Related Report
      2015 Research-status Report
  • [Presentation] 脳内性ホルモンと神経機能2015

    • Author(s)
      川戸佳
    • Organizer
      抗加齢内分泌研究会
    • Place of Presentation
      東大
    • Year and Date
      2015-09-06
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 脳のニューロステロイド:メス海馬が合成する女性ホルモンが制御する神経シナプスと海馬の性周期2015

    • Author(s)
      加藤麻紗実 北条泰嗣 川戸佳
    • Organizer
      神経科学会
    • Place of Presentation
      神戸
    • Year and Date
      2015-07-28
    • Related Report
      2015 Research-status Report
  • [Presentation] 海馬が合成する男性・女性ホルモンによるLTPと神経スパインの制御2015

    • Author(s)
      川戸佳 北条泰嗣
    • Organizer
      神経科学会
    • Place of Presentation
      神戸
    • Year and Date
      2015-07-28
    • Related Report
      2015 Research-status Report
  • [Presentation] テストステロンは脳海馬の記憶神経をうまく制御している2014

    • Author(s)
      川戸佳
    • Organizer
      日本Men's Health 医学会
    • Place of Presentation
      千里ライフサイエンスセンター(大阪)
    • Year and Date
      2014-09-27
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 脳海馬で合成される女性ホルモンによる長期増強の急性的制御2014

    • Author(s)
      長谷川賢卓、川戸佳
    • Organizer
      日本神経科学会
    • Place of Presentation
      横浜パシフィコ(神奈川)
    • Year and Date
      2014-09-12
    • Related Report
      2014 Research-status Report
  • [Presentation] メス海馬の作り出す性周期と神経シナプスの変動~ホルモンとシナプスの性差2014

    • Author(s)
      北条泰嗣、川戸佳
    • Organizer
      日本神経科学会
    • Place of Presentation
      横浜パシフィコ(神奈川)
    • Year and Date
      2014-09-12
    • Related Report
      2014 Research-status Report
  • [Presentation] テストステロンは脳海馬の記憶神経を活性化する2014

    • Author(s)
      川戸佳
    • Organizer
      日本抗加齢医学会総会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Year and Date
      2014-06-07
    • Related Report
      2014 Research-status Report
    • Invited
  • [Remarks] http://kawato-glia.sakura.ne.jp

    • Related Report
      2016 Annual Research Report
  • [Remarks] 東京大学 川戸研究室

    • URL

      http://kawato-glia.sakura.ne.jp/

    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

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