Hippocampus-synthesized brain steroids are strong modulators of neuronal synapses and memory
| Project/Area Number |
26430006
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurophysiology / General neuroscience
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| Research Institution | Juntendo University (2015-2016)
The University of Tokyo (2014) |
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Principal Investigator |
KAWATO Suguru 順天堂大学, 医学部, 客員教授 (50169736)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 神経内分泌学 / 脳ステロイド / 海馬 / シナプス / 記憶 / 神経ステロイド |
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| Outline of Final Research Achievements |
Sex-steroids rapidly and non-genomically modulated the dendritic spines in the rat hippocampus. We analyzed the molecular mechanisms of these modulations by using 3-dimentional confocal microscopic imaging of neuronal synapses. Upon application of male hormones (T and DHT) and female hormones (E2 PROG) for 2 h, the density of dendritic spines were significantly increased. The signal pathways of these modulations were “binding of sex-steroids to their classic steroid receptors in spines → phosphorylation of kinases such as LIMK and MAPK → phosphorylation of cofilin and cortactin → actin polymerization → spine increase”. From electrophysiological investigations, nongenomic pathway of E2-induced long-term potentiation was also found.
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Report
(4 results)
Research Products
(28 results)
