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Elucidating synergistic motor learning mechanisms by distributed multiple plasticity in the cerebellum

Research Project

Project/Area Number 26430009
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurophysiology / General neuroscience
Research InstitutionThe University of Electro-Communications

Principal Investigator

Yamazaki Tadashi  電気通信大学, 大学院情報理工学研究科, 准教授 (40392162)

Co-Investigator(Kenkyū-buntansha) 田中 繁  電気通信大学, 脳科学ライフサポート研究センター, 特任教授 (70281706)
Research Collaborator GOSUI Masato  
FURUSHO Wataru  
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords小脳 / シナプス可塑性 / 理論 / シミュレーション / 高性能神経計算 / 運動学習 / モデル / 記憶学習 / 記憶 / 眼球運動
Outline of Final Research Achievements

Long-term depression at parallel fiber-Purkinje cell synapses seems to play the essential role in cerebellar motor learning, but recent experiments demonstrate multiple plasticity mechanisms at distributed sites within the cerebellum. The present study aimed to clarify the synergistic role of those plasticity mechanisms for motor learning from the theoretical view point. We proposed a unified theoretical framework for cerebellar motor learning, and varidated our theory by large-scale computer simulation. We also built a very large-scale realistic cerebellar model on a supercomputer. Finally, we reconciled the computational principle of the cerebellum, and suggested that the cerebellum with multiple plasticity mechanisms could perform much stronger computation than that used to be considered as a perceptron.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (13 results)

All 2017 2016 2015 2014 Other

All Journal Article (4 results) (of which Peer Reviewed: 3 results,  Open Access: 3 results,  Acknowledgement Compliant: 3 results) Presentation (8 results) (of which Int'l Joint Research: 5 results,  Invited: 2 results) Remarks (1 results)

  • [Journal Article] Realtime simulation of a cat-scale artificial cerebellum on PEZY-SC processors2017

    • Author(s)
      Tadashi Yamazaki, Jun Igarashi, Junichiro Makino, Toshikazu Ebisuzaki
    • Journal Title

      International Journal of High Performance Computing Applications

      Volume: 印刷中

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] パーセプトロンと小脳2016

    • Author(s)
      山﨑 匡, 牧野 淳一郎, 戎崎 俊一
    • Journal Title

      臨床神経学

      Volume: 34 Pages: 889-891

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Real-world-time simulation of memory consolidation in a large-scale cerebellar model2015

    • Author(s)
      Masato Gosui, Tadashi Yamazaki
    • Journal Title

      Frontiers in Neuroanatomy

      Volume: 10

    • DOI

      10.3389/fnana.2016.00021

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Modeling memory consolidation during post-training periods in cerebellovestibular learning2015

    • Author(s)
      Tadashi Yamazaki, Soichi Nagao, William Lennon, Shigeru Tanaka
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 112 Issue: 11 Pages: 3541-3546

    • DOI

      10.1073/pnas.1413798112

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Efficient numerical simulation of neuron models with spatial structure on graphics processing units2016

    • Author(s)
      Tsukasa Tsuyuki, Yuki Yamamoto, Tadashi Yamazaki
    • Organizer
      ICONIP 2016
    • Place of Presentation
      京大 (京都・京都)
    • Year and Date
      2016-10-16
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Efficient computer simulation of spatial neuron models with graphics processing units2016

    • Author(s)
      Tadashi Yamazaki, Yuki Yamamoto, Tsukasa Tsuyuki
    • Organizer
      日本神経科学大会
    • Place of Presentation
      パシフィコ横浜 (神奈川・横浜)
    • Year and Date
      2016-07-20
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Shoubuで実現するネコ一匹分の人工小脳2016

    • Author(s)
      山﨑 匡
    • Organizer
      理研シンポジウム「スーパーコンピュータHOKUSAIとShoubu、研究開発の最前線」
    • Place of Presentation
      理研 (埼玉・和光)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 前庭動眼反射の長期適応に関する小脳モデル2015

    • Author(s)
      山﨑 匡
    • Organizer
      第25回日本神経回路学会全国大会
    • Place of Presentation
      電気通信大学 (東京・調布)
    • Year and Date
      2015-09-02
    • Related Report
      2015 Research-status Report
  • [Presentation] Building a 1 mm^3 cerebellar module on a computer2015

    • Author(s)
      Tadashi Yamazaki
    • Organizer
      INCF Congress Neuroinformatics 2015
    • Place of Presentation
      Cairns (Australia)
    • Year and Date
      2015-08-21
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Realtime simulation of memory consolidation in a large-scale cerebellar model2015

    • Author(s)
      Masato Gosui, Tadashi Yamazaki
    • Organizer
      INCF Congress Neuroinformatics 2015
    • Place of Presentation
      Cairns (Australia)
    • Year and Date
      2015-08-21
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Modeling the cerebellum: Top-down approach and bottom-up approach2015

    • Author(s)
      Tadashi Yamazaki
    • Organizer
      第38回日本神経科学学会
    • Place of Presentation
      神戸国際会議場 (兵庫・神戸)
    • Year and Date
      2015-07-28
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Realtime simulation of one-million spiking neurons in a realistic cerebellar model using multiple GPUs2014

    • Author(s)
      Tadashi Yamazaki
    • Organizer
      Advances in Neuroinformatics (AINI2014)
    • Place of Presentation
      理化学研究所
    • Year and Date
      2014-09-25 – 2014-09-26
    • Related Report
      2014 Research-status Report
  • [Remarks] 【メディアリリース】小脳における記憶の定着過程の理論を提唱

    • URL

      http://www.uec.ac.jp/news/announcement/2014/20150226-1.html

    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

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