Target analyses of Otx2 homeoprotein in postnatal plasticity
| Project/Area Number |
26430010
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurophysiology / General neuroscience
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| Research Institution | Niigata University |
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Principal Investigator |
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| Research Collaborator |
SAKAI Akiko
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 臨界期 / ホメオ蛋白質 / 抑制性介在ニューロン / 眼優位性可塑性 / 視覚野 / 眼優位性 / Otx2 / 弱視 |
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| Outline of Final Research Achievements |
Neuronal circuits are sharpened by experience during critical periods in early life. We previously demonstrated that Otx2 functions as an inducer of the critical period in mouse postnatal visual cortex. In this study, we investigated Otx2 target genes such as transcription factors or homeoproteins by chromatin immunoprecipitation sequencing (ChIP-seq) and cell-type specific RNA-seq analyses for critical period plasticity. Our results suggest some homeoproteins and immediate-early genes (IEGs) as novel targets of Otx2. Otx2 may render the chromatin environment capable of an immediate response to neuronal depolarization and may be required for such a ‘poised’ state of histone modifications of IEGs promoters. Our data indicates that Otx2-induced genetic cascade is broadly involved in neuronal plasticity as well as critical period.
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Report
(4 results)
Research Products
(15 results)
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[Journal Article] Chondroitin Sulfate Is Required for Onset and Offset of Critical Period Plasticity in Visual Cortex2017
Author(s)
Xubin Hou, Nozomu Yoshioka, Hiroaki Tsukano, Akiko Sakai, Shinji Miyata, Yumi Watanabe, Yuchio Yanagawa, Kenji Sakimura, Kosei Takeuchi, Hiroshi Kitagawa, Takao Hensch, Katsuei Shibuki, Michihiro Igarashi, Sayaka Sugiyama
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Journal Title
Scientific Reports
Volume: ―
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Genome-Wide Target Analyses of Otx2 Homeoprotein in Postnatal Cortex2017
Author(s)
Akiko Sakai, Ryuichiro Nakato, Yiwei Ling, Xubin Hou, Norikazu Hara, Tomoya Iijima, Yuchio Yanagawa, Ryozo Kuwano, Shujiro Okuda, Katsuhiko Shirahige, Sayaka Sugiyama
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Journal Title
Frontiers in Neuroscience
Volume: ―
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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