Functional analysis of the mouse posterior parietal cortex that forms the filter of selective attention

• Project/Area Number: 26430011
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurophysiology / General neuroscience
• Research Institution: Niigata University
• Principal Investigator: Hishida Ryuichi 新潟大学, 脳研究所, 准教授 (90313551)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 神経科学 / 脳・神経 / 生理学 / 可視化 / 認知科学 / 注意 / フラビン蛋白質イメージング / マウス

Outline of Final Research Achievements

Although we found that the feedback projection from the mouse posterior parietal cortex (PPC) to the primary visual cortex (V1) exists and suppresses V1, its physiological role was unknown. Therefore, we made a hypothesis that the projection from the PPC forms an initial selection filter of selective attention in V1, and proceeded with the analysis. We found that (1) the PPC has an ability to cause plastic changes in V1 responses to visual stimuli in a selective manner, (2) the PPC modifies the direction selectivity of excitatory neurons in V1, (3) the function of the V1 suppression is mapped to the PPC, etc. These results are supposed to support the hypothesis and encourage the further analysis.

Research Products

• [Journal Article] Tomographic optical imaging of cortical responses after crossing nerve transfer in mice (2018)
  • Author(s): Maniwa K, Yamashita H, Tsukano H, Hishida R, Endo N, Shibata M, Shibuki K
  • Journal Title: PLoS One Volume: 13 Issue: 2 Pages: e0193017-e0193017
  • DOI: 10.1371/journal.pone.0193017
  • Peer Reviewed / Open Access
• [Journal Article] Corrigendum: Reconsidering Tonotopic Maps in the Auditory Cortex and Lemniscal Auditory Thalamus in Mice (2017)
  • Author(s): Tsukano H, Horie M, Ohga S, Takahashi K, Kubota Y, Hishida R, Takebayashi H, Shibuki K
  • Journal Title: Frontiers in Neural Circuits Volume: 11 Pages: 39-39
  • DOI: 10.3389/fncir.2017.00039
  • Peer Reviewed / Open Access
• [Journal Article] Reconsidering Tonotopic Maps in the Auditory Cortex and Lemniscal Auditory Thalamus in Mice. (2017)
  • Author(s): 1.Tsukano H, Horie M, Ohga S, Takahashi K, Kubota Y, Hishida R, Takebayashi H, Shibuki K
  • Journal Title: Front Neural Circuits Volume: 11 Pages: 14-14
  • DOI: 10.3389/fncir.2017.00014
  • Peer Reviewed / Open Access
• [Journal Article] Independent tonotopy and thalamocortical projection patterns in two adjacent parts of the classical primary auditory cortex in mice. (2017)
  • Author(s): 2.Tsukano H, Horie M, Takahashi K, Hishida R, Takebayashi H, Shibuki K
  • Journal Title: Neurosci Lett Volume: 637 Pages: 26-30
  • DOI: 10.1016/j.neulet.2016.11.062
  • Peer Reviewed / Open Access
• [Journal Article] Auditory cortical field coding long-lasting tonal offsets in mice. (2016)
  • Author(s): 3.Baba H, Tsukano H, Hishida R, Takahashi K, Horii A, Takahashi S, Shibuki K
  • Journal Title: Scientific Reports Volume: 6 Issue: 1 Pages: 34421-34421
  • DOI: 10.1038/srep34421
  • Peer Reviewed / Open Access
• [Journal Article] Quantitative map of multiple auditory cortical regions with a stereotaxic fine-scale atlas of the mouse brain. (2016)
  • Author(s): Hiroaki Tsukano, Masao Horie, Ryuichi Hishida, Kuniyuki Takahashi, Hirohide Takebayashi, Katsuei Shibuki
  • Journal Title: Sci Rep. Volume: 6 Issue: 1 Pages: 22315-22315
  • DOI: 10.1038/srep22315
  • Peer Reviewed / Open Access
• [Journal Article] mpaired clustered protocadherin-α leads to aggregated retinogeniculate terminals and impaired visual acuity in mice. (2015)
  • Author(s): Meguro R, Hishida R, Tsukano H, Yoshitake K, Imamura R, Tohmi M, Kitsukawa T, Hirabayashi T, Yagi T, Takebayashi H, Shibuki K
  • Journal Title: J Neurochem Volume: 133 Issue: 1 Pages: 66-72
  • DOI: 10.1111/jnc.13053
  • Peer Reviewed / Open Access
• [Journal Article] Delineation of a frequency-organized region isolated from the mouse primary auditory cortex. (2015)
  • Author(s): Tsukano H, Horie M, Bo T, Uchimura A, Hishida R, Kudoh M, Takahashi K, Takebayashi H, Shibuki K
  • Journal Title: J Neurophysiol Volume: 印刷中 Issue: 7 Pages: 2900-2920
  • DOI: 10.1152/jn.00932.2014
  • Peer Reviewed / Open Access
• [Journal Article] Spinal mechanisms underlying potentiation of hindpaw responses observed after transient hindpaw ischemia in mice. (2015)
  • Author(s): Tatsunori Watanabe, Mika Sasaki, Seiji Komagata, Hiroaki Tsukano, Ryuichi Hishida, Tatsuro Kohno, Hiroshi Baba, Katsuei Shibuki
  • Journal Title: Sci Rep. Volume: 5 Issue: 1 Pages: 11191-11191
  • DOI: 10.1038/srep11191
  • Peer Reviewed / Open Access
• [Journal Article] Multimodal cortical sensory pathways revealed by sequential transcranial electrical stimulation in mice. (2014)
  • Author(s): Hishida R, Kudoh M, Shibuki K
  • Journal Title: Neurosci Re Volume: 8 Pages: 49-55
  • DOI: 10.1016/j.neures.2014.07.004
  • Peer Reviewed
• [Presentation] マウス頭頂連合野から一次視覚野への抑制投射は視覚応答の可塑的変化を特徴選択的に誘導する (2017)
  • Author(s): 菱田竜一
  • Organizer: 日本神経科学会
• [Presentation] マウス一次視覚野興奮性ニューロンの特徴選択性は頭頂連合野からの抑制投射により制御される (2016)
  • Author(s): 菱田竜一
  • Organizer: 日本神経科学会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
• [Presentation] マウス頭頂連合野から一次視覚野への抑制投射の２光子イメージングによる解析 (2015)
  • Author(s): 菱田竜一
  • Organizer: 日本神経科学会
  • Place of Presentation: 神戸国際会議場（兵庫県・神戸市）
  • Year and Date: 2015-07-30
• [Presentation] 視覚野を抑制するマウス頭頂連合野 (2014)
  • Author(s): 菱田竜一
  • Organizer: 日本神経科学会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2014-09-12
• [Remarks] 新潟大学脳研究所システム脳生理学分野ホームページ
  • URL: http://www.bri.niigata-u.ac.jp/~physio/