| Project/Area Number |
26430013
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurophysiology / General neuroscience
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
米田 貢 金沢大学, 保健学系, 准教授 (70334787)
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| Co-Investigator(Renkei-kenkyūsha) |
KIKUCHI Yui 金沢大学, 保健学系, 助教 (00749137)
SUGIMOTO Naotoshi 金沢大学, 医学系, 准教授 (80272954)
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| Research Collaborator |
ECHIGO Ryosuke
SUGAWARA Yuto
TANIGAMI Hayate
OTA Tetsuo
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 脳・神経 / ニューロン / 神経科学 / カンナビノイド / シナプス活動 / 行動柔軟性 / シナプス伝達 / 海馬ニューロン / CB1受容体 / 2-AG / アナンダミド / アラキドン酸 |
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| Outline of Final Research Achievements |
Roles of the major endocannabinoid 2-AG and its metabolites in brain functions were examined by measuring electrical activities of rat cultured hippocampal neuros and analyzing the performance of mice on three-lever operant task. We found that 2-AG and its metabolites increase the synaptic activity in a CB1-independent manner, that the ligand-independent basal activity of CB1 receptors supports synaptic activity, and that the endocannabinoid system involving 2-AG and CB1 receptors plays a role in behavioral flexibility.
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