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Participation of LRP4 receptor which is indispensable to neuromuscular junctions in central nervous system

Research Project

Project/Area Number 26430014
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurophysiology / General neuroscience
Research InstitutionShinshu University

Principal Investigator

TANAHASHI Hiroshi  信州大学, 学術研究院医学系, 准教授 (90236654)

Co-Investigator(Kenkyū-buntansha) 鈴木 龍雄  信州大学, 学術研究院医学系, 教授 (80162965)
Co-Investigator(Renkei-kenkyūsha) SAKAGAMI Hiroyuki  北里大学, 医学部, 教授 (90261528)
HARA Yoshinobu  北里大学, 医学部, 助教 (40558467)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords神経可塑性 / シナプス / 合指多指症 / 歯数過剰 / 不正咬合 / 腎臓欠失 / 羊水過多 / アクアポリン
Outline of Final Research Achievements

Amniotic fluid volume during mid-to-late gestation depends mainly on the urine excretion from the fetal kidneys and partly on the fluid secretion from the fetal lungs during fetal breathing-like movements. Lrp4, which functions as an agrin receptor, is essential for the formation of neuromuscular junctions. Herein, we report novel phenotypes of Lrp4 KO mice. Most KO fetuses showed unilateral or bilateral kidney agenesis, and Lrp4 knockout resulted in polyhydramnios. The loss of Lrp4 compromised fetal swallowing and breathing-like movements and downregulated the expression of AQP9 in the fetal membrane and AQP1 in the placenta, which possibly affected the amniotic fluid clearance. These results suggest that amniotic fluid removal was compromised in KO fetuses, resulting in polyhydramnios despite the impairment of urine production. Our findings indicate that amniotic fluid removal plays an essential role in regulating the amniotic fluid volume during mid-to-late gestation.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (2 results)

All 2016

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (1 results)

  • [Journal Article] Polyhydramnios in Lrp4 knockout mice with bilateral kidney agenesis: Defects in the pathways of amniotic fluid clearance.2016

    • Author(s)
      Tanahashi, H.;Tian, Q.B.; Hara, Y.;Sakagami, H.;Endo, S.;Suzuki, T.
    • Journal Title

      Sci Rep

      Volume: 6 Issue: 1 Pages: 20241-20241

    • DOI

      10.1038/srep20241

    • NAID

      120007100143

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 両腎形成不全を伴うLrp4欠失マウスは羊水の排出に異常を来し羊水過多を起こす2016

    • Author(s)
      棚橋浩、田慶宝、遠藤昌吾、鈴木龍雄
    • Organizer
      第63回日本実験動物学会総会
    • Place of Presentation
      川崎(ミューザ川崎シンフォニーホール)
    • Year and Date
      2016-05-18
    • Related Report
      2016 Annual Research Report

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Published: 2014-04-04   Modified: 2018-03-22  

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