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Elucidation of ligand-receptor signaling that regulates the corticospinal tract collateralization

Research Project

Project/Area Number 26430017
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurophysiology / General neuroscience
Research InstitutionOsaka University

Principal Investigator

IGUCHI TOKUICHI  大阪大学, 医学系研究科, 助教 (60509305)

Co-Investigator(Kenkyū-buntansha) 森 泰丈  大阪大学, 医学系研究科, 准教授 (00343252)
尾身 実  藤田保健衛生大学, 医学部, 助教 (00400416)
佐藤 真  大阪大学, 連合小児発達学研究科, 教授 (10222019)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords神経科学 / 解剖学 / 発生・分化 / 神経回路 / 軸索側枝
Outline of Final Research Achievements

Corticospinal tract, which is the major subcortical output from the neocortex, extends the axon collaterals from the main shaft to several nuclei, enabling coordination of neural activity. In order to clarify the molecular mechanism controlling the formation of axon collaterals, we screened and analyzed candidate receptors and their ligands which are involved in axon collateral formation. We found that one of the candidate receptors (receptor #13) and its ligand were complementarily expressed in the cortex and the pontine nucleus, and their expression pattern determined the projection area of the axon collateral branches. Furthermore, receptor #13 was also involved in collateral branch formation that plays a compensatory mechanism during brain injury. These results are of great significance to elucidate the common molecular basis that underlies axon collateralization and to subsequently apply in recovery of neural function.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (27 results)

All 2016 2015 2014 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (23 results) (of which Int'l Joint Research: 5 results,  Invited: 1 results) Remarks (2 results)

  • [Journal Article] DBZ regulates cortical cell positioning and neurite development by sustaining the anterograde transport of Lis1 and DISC1 through control of Ndel1 dual-phosphorylation.2015

    • Author(s)
      1.Okamoto, M., Iguchi, T., Hattori, T., Matsuzaki, S., Koyama, Y., Taniguchi, M., Kodama, M., Xie, M-J., Yagi, H., Shimizu, S., Konishi, Y., Yoshimi, T., Tachibana, T., Fujieda, S., Katayama, T., Ito, A., Hirotsune, S., Tohyaman, M. and Sato, M.
    • Journal Title

      J Neurosci

      Volume: 18 Issue: 7 Pages: 2942-2958

    • DOI

      10.1523/jneurosci.5029-13.2015

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Filamin A-interacting protein (FILIP) is a region-specific modulator of myosin 2b and controls spine morphology and NMDA receptor accumulation.2014

    • Author(s)
      Hideshi Yagi,Takashi Nagano,Min-Jue Xie,Hiroshi Ikeda,Kazuki Kuroda,Munekazu Komada,Tokuichi Iguchi,Rahman M. Tariqur,Soichi Morikubo,Koichi Noguchi,Kazuyuki Murase,Masaru Okabe& Makoto Sato
    • Journal Title

      Scientific reports

      Volume: 4 Issue: 1 Pages: 6353-6353

    • DOI

      10.1038/srep06353

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 膜脂質結合タンパク質Phldb2を介したAMPA受容体局在制御機構2016

    • Author(s)
      謝 敏かく、八木 秀司、猪口 徳一、岡 雄一郎、黒田 一樹、深澤 有吾、松崎 秀夫、岩田 圭子、石川 保幸、佐藤 真
    • Organizer
      第121回日本解剖学会総会 全国学術集会
    • Place of Presentation
      ビッグパレットふくしま、福島県郡山市
    • Year and Date
      2016-03-28
    • Related Report
      2015 Research-status Report
  • [Presentation] RNA結合タンパク質hnRNP K のアルギニンメチル化修飾を介したmRNA輸送制御機構の解明2016

    • Author(s)
      森 泰丈、猪口 徳一、遠山 正彌、佐藤 真
    • Organizer
      第121回日本解剖学会総会 全国学術集会
    • Place of Presentation
      ビッグパレットふくしま、福島県郡山市
    • Year and Date
      2016-03-28
    • Related Report
      2015 Research-status Report
  • [Presentation] 逆行性物質輸送が神経ネットワーク形成に与える影響について2016

    • Author(s)
      熊本 香名子, 猪口 徳一, 上村 卓也, 佐藤 真, 広常 真治
    • Organizer
      第121回日本解剖学会総会 全国学術集会
    • Place of Presentation
      ビッグパレットふくしま、福島県郡山市
    • Year and Date
      2016-03-28
    • Related Report
      2015 Research-status Report
  • [Presentation] DBZはNdel1のリン酸化修飾制御を通して軸索伸長および皮質神経細胞の配置に関与する2016

    • Author(s)
      猪口 徳一、岡本 昌之、 服部 剛志、松崎 伸介、駒田 致和、謝 敏カク、八木 秀司、広常 真治、遠山 正彌、佐藤 真
    • Organizer
      第121回日本解剖学会総会 全国学術集会
    • Place of Presentation
      ビッグパレットふくしま、福島県郡山市
    • Year and Date
      2016-03-28
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Phosphoinositide responsive phldb2 regulates synaptic plasticity2016

    • Author(s)
      M. Xie, H. Yagi, T. Iguchi, Y. Oka, Y. Fukazawa, H. Matsuzaki, K. Iwata, Y. ishikawa, M. Sato
    • Organizer
      Neuroscience 2016, SfN's 46th annual meeting
    • Place of Presentation
      San Diego, U.S.A.
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] PRMT1-dependent arginine methylation on hnRNP K regulates dendritic transport of alpha CaMKII mRNA2016

    • Author(s)
      Y. Mori, T. Iguchi, S. Miyata, M. Tohyama, M. Sato
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜、神奈川県横浜市
    • Related Report
      2016 Annual Research Report
  • [Presentation] Visualization and developmental analysis of the inter-areal connections in the mouse cortex using a new method for sparse labeling2016

    • Author(s)
      Y. Oka, T. Iguchi, M. Sato
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜、神奈川県横浜市
    • Related Report
      2016 Annual Research Report
  • [Presentation] A new method to amplify the reporter expression in the Cre/loxP system applicable to cortical development study2016

    • Author(s)
      Y. Oka, T. Iguchi, M. Sato
    • Organizer
      21st Biennial Meeting of the International Society for Developmental Neuroscience
    • Place of Presentation
      Palais des Congres d’Antibes Juan les Pins, France
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] RNAタンパク質hnRNPKのアルギニンメチル化修飾が樹状突起へのmRNA輸送を制御する2015

    • Author(s)
      森 泰丈、猪口 徳一、遠山 正彌、佐藤 真
    • Organizer
      第91回日本解剖学会 近畿支部学術集会
    • Place of Presentation
      京都工芸繊維大学、京都府京都市
    • Year and Date
      2015-11-28
    • Related Report
      2015 Research-status Report
  • [Presentation] Arginine methylated form of hnRNP K variant mediates a dendritic localization of αCaMKII mRNA2015

    • Author(s)
      Y. Oka, Y. Mori, T. Iguch, M. Tohyama, M. Sato.
    • Organizer
      Neuroscience 2015, SfN's 45th annual meeting
    • Place of Presentation
      Chicago, U.S.A.
    • Year and Date
      2015-10-17
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] FILIP-related molecule binds to NMDA receptor and controls spine maturation and synaptic function of the hippocampal nuron2015

    • Author(s)
      K. Kuroda, H. Yagi, M. Xie, Y. Fukazawa, Y. Oka, T. Iguch, M. Sato.
    • Organizer
      Neuroscience 2015, SfN's 45th annual meeting
    • Place of Presentation
      Chicago, U.S.A.
    • Year and Date
      2015-10-17
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] DISC1-binding zinc finger protein (DBZ) regulates cortical cell positioning and neurite elongation through control of Ndel1 dual-phosphorylation2015

    • Author(s)
      T. Iguch, M. Okamoto, T. Hattori, S. Matsuzaki, Y. Koyama, M. Taniguchi, M. Komada, M. Xie, H. Yagi, S. Shimizu, M. Omi, T. Katayama, A. Ito, S. Hirotsune, M. Tohyama, M. Sato.
    • Organizer
      Neuroscience 2015, SfN's 45th annual meeting
    • Place of Presentation
      Chicago, U.S.A.
    • Year and Date
      2015-10-17
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Development of axon collaterals as the inter-areal connections in the cerebral cortex.2015

    • Author(s)
      岡 雄一郎、猪口 徳一、佐藤 真
    • Organizer
      第58回日本神経化学会大会
    • Place of Presentation
      大宮ソニックシティ、埼玉県大宮市
    • Year and Date
      2015-09-11
    • Related Report
      2015 Research-status Report
  • [Presentation] Functional analysis of protein arginine N-methyltransferase 8 (PRMT8) in activated microglia that are induced by spinal cord injury2015

    • Author(s)
      森 泰丈、小山 佳久、猪口 徳一、宮田 信吾、遠山 正彌、佐藤 真
    • Organizer
      第58回日本神経化学会大会
    • Place of Presentation
      大宮ソニックシティ、埼玉県大宮市
    • Year and Date
      2015-09-11
    • Related Report
      2015 Research-status Report
  • [Presentation] マウス大脳皮質領野間回路の形成過程の解析2015

    • Author(s)
      岡 雄一郎、赤嶺祥真、猪口徳一、佐藤 真
    • Organizer
      第16回 ORIGIN 神経科学研究会 2015
    • Place of Presentation
      下関市豊北生涯学習センター、山口県下関市
    • Year and Date
      2015-08-28
    • Related Report
      2015 Research-status Report
  • [Presentation] 皮質脊髄路側枝形成を制御する受容体による皮質-橋-小脳路の形成機構2015

    • Author(s)
      猪口徳一、尾身 実、岡 雄一郎、佐藤 真
    • Organizer
      第16回 ORIGIN 神経科学研究会 2015
    • Place of Presentation
      下関市豊北生涯学習センター、山口県下関市
    • Year and Date
      2015-08-28
    • Related Report
      2015 Research-status Report
  • [Presentation] 受容体チロシンキナーゼとその反発性結合分子は脳内で相補的に発現することで軸索側枝の投射様式を制御し皮質‐橋‐小脳路の形成に関わる2015

    • Author(s)
      猪口 徳一、尾身 実、岡 雄一郎、佐藤 真
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸国際会議場・展示場、兵庫県神戸市
    • Year and Date
      2015-07-28
    • Related Report
      2015 Research-status Report
  • [Presentation] Phldb2はスナプスの可塑性を制御する2015

    • Author(s)
      謝敏かく、八木秀司、猪口徳一、岡雄一郎、黒田一樹、深澤有吾、松崎秀夫、岩田圭子、柚崎通介、松田信爾、石川保幸、佐藤 真
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸国際会議場・展示場、兵庫県神戸市
    • Year and Date
      2015-07-28
    • Related Report
      2015 Research-status Report
  • [Presentation] 海馬神経細胞におけるNMDAレセプタに結合するFILIP関連分子の機能解析2015

    • Author(s)
      黒田 一樹、八木 秀司、謝 敏かく、尾身 実、深澤 有吾、岡 雄一郎、猪口 徳一、佐藤 真
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸国際会議場・展示場、兵庫県神戸市
    • Year and Date
      2015-07-28
    • Related Report
      2015 Research-status Report
  • [Presentation] 皮質ニューロン軸索側枝による領野間結合の発達2015

    • Author(s)
      岡 雄一郎、猪口 徳一、佐藤 真
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸国際会議場・展示場、兵庫県神戸市
    • Year and Date
      2015-07-28
    • Related Report
      2015 Research-status Report
  • [Presentation] Analyses on the candidate receptors for the axon collateralization of the developing corticospinal tract2015

    • Author(s)
      Tokuichi Iguchi, Minoru Omi, Yuichiro Oka, Makoto Sato
    • Organizer
      第120回 日本解剖学会総会・全国学術集会
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市)
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Research-status Report
  • [Presentation] 皮質脊髄路側枝形成に関与する受容体分子の探索と解析2014

    • Author(s)
      猪口 徳一 、尾身 実 、岡 雄一郎、森 泰丈 、佐藤 真
    • Organizer
      第90回 日本解剖学会近畿支部学術集会
    • Place of Presentation
      大阪大学医学部(大阪府吹田市)
    • Year and Date
      2014-11-29
    • Related Report
      2014 Research-status Report
  • [Presentation] 皮質脊髄路側枝形成に関与する受容体分子の探索と解析2014

    • Author(s)
      猪口 徳一
    • Organizer
      第15回 ORIGIN 神経科学会研究会 夏のワークショップ
    • Place of Presentation
      松本浅間温泉地本屋(長野県松本市)
    • Year and Date
      2014-08-31 – 2014-09-01
    • Related Report
      2014 Research-status Report
  • [Remarks] 大阪大学大学院医学系研究科 解剖学講座(神経機能形態学)ホームページ

    • URL

      http://www.anat2.med.osaka-u.ac.jp/index.html

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
  • [Remarks] 神経機能形態学(旧第二解剖)のホームページ

    • URL

      http://www.anat2.med.osaka-u.ac.jp/

    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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