| Project/Area Number |
26430018
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurophysiology / General neuroscience
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| Research Institution | Ehime University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
MURAKAMI YASUNORI 京都府立医科大学, 医学研究科, 准教授 (10323007)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 進化 / 脳 / 脊椎動物 / 発生 / 遺伝子 |
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| Outline of Final Research Achievements |
Since the ancestors of mammals and birds have diverged from their common ancestor (stem amniotes) , the brains of animals in each lineage are thought to have developed independently. Thus, to clarify the evolutionary transition of the telencephalon, the highest integrative center in amniotes, we compared the developmental plan in mouse, chicken, turetle, gecko and snake. We studied the expression patterns of transcription factors and axon guidance molecules in primordia of diencephalon and telencephalon, and found that expression of some axon guidance factors in reptiles were similar to those of mouse embryo, suggesting that the basic mechanisms underlying the connection between diencephalon and telencephalon are shared across amniote lineages. Conversely, telencephalon patterning genes are differentially expressed in animals studied. This indicates that changes in the expression domains of pallium-patterning genes are a prerequisite for the diversification of complex brain centers.
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