Developmental plan in reptilian telencephalon: with reference to the evolution of two distinct brain centers
| Project/Area Number |
26430018
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurophysiology / General neuroscience
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| Research Institution | Ehime University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
MURAKAMI YASUNORI 京都府立医科大学, 医学研究科, 准教授 (10323007)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 進化 / 脳 / 脊椎動物 / 発生 / 遺伝子 |
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| Outline of Final Research Achievements |
Since the ancestors of mammals and birds have diverged from their common ancestor (stem amniotes) , the brains of animals in each lineage are thought to have developed independently. Thus, to clarify the evolutionary transition of the telencephalon, the highest integrative center in amniotes, we compared the developmental plan in mouse, chicken, turetle, gecko and snake. We studied the expression patterns of transcription factors and axon guidance molecules in primordia of diencephalon and telencephalon, and found that expression of some axon guidance factors in reptiles were similar to those of mouse embryo, suggesting that the basic mechanisms underlying the connection between diencephalon and telencephalon are shared across amniote lineages. Conversely, telencephalon patterning genes are differentially expressed in animals studied. This indicates that changes in the expression domains of pallium-patterning genes are a prerequisite for the diversification of complex brain centers.
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Report
(4 results)
Research Products
(34 results)
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[Journal Article] The evolution of basal progenitors in the developing non-mammalian brain.2016
Author(s)
NOmura, T., Ohtaka-Maruyama, C., Yamashita, W., Wakamatsu, Y., Murakami, Y., Calegari, F., Suzuki, K., Gotoh, H., Ono, K.
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Journal Title
Development
Volume: 143
Issue: 1
Pages: 66-74
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Evidence from cyclostomes for complex regionalization of the ancestral vertebrate brain2016
Author(s)
Fumiaki Sugahara, Juan Pascual-Anaya, Yasuhiro Oisi, Shigehiro Kuraku, Shin-IchiAota, Noritaka Adachi, Wataru Takagi, Tamami Hirai, Noboru Sato, Yasunori Murakami, Shigeru Kuratani
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Journal Title
Nature
Volume: 531
Issue: 7592
Pages: 97-100
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Development of the thalamo-DVR tract in the Chinese soft-shelled turtle Pelodiscus sinensis.2014
Author(s)
Tosa, Y., Hirao, A., Matsubara, I., Kawaguchi, M., Nagashima, H., Kuratani, S., and Murakami, Y.
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Journal Title
Dev. Growth Diff.
Volume: 57
Issue: 1
Pages: 40-57
DOI
Related Report
Peer Reviewed
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[Presentation] 羊膜類の終脳発生機構2015
Author(s)
平尾綾子, 土佐靖彦, 村上安則
Organizer
日本動物学会・中国四国地区生物系三学会合同大会
Place of Presentation
愛媛県・松山市 愛媛大学
Year and Date
2015-05-17
Related Report
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