| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
We analyzed mechanisms of olfactory preference changes after odor experiences or depending on odor concentrations with our original assay system using C. elegans. In this study, we identified interneurons involved in the preference change after experiences and observed switch of neural activation. We also analyzed functions of neuropeptide signals and the Ras-MAPK pathway in experience-induced olfactory preference changes. VDAC-1 channel was newly identified for a direct target of MAPK in olfactory systems. Furthermore, we elucidated the preference change depending on odor concentrations is regulated by changes of neural circuits working.
We succeeded in development of time- and cell-specific RNAi (T.C.RNAi) contributing to regulation of molecular functions at objective time and space.
We discovered olfactory preference changes in C. elegans can be used for a medical examination.
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