Development and evolution of the frontal cortex
| Project/Area Number |
26430033
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Tohoku University |
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Principal Investigator |
Sato Tatsuya 東北大学, 情報科学研究科, 准教授 (00568222)
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| Co-Investigator(Kenkyū-buntansha) |
大隅 典子 東北大学, 医学系研究科, 教授 (00220343)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 内側前頭前野 / 嗅球 / 眼窩前頭皮質 / 電気穿孔法 / マウス / 線維芽細胞増殖因子 / 形態形成 / FGF8 / 大脳皮質 / 前頭前野 / 神経回路形成 / ドーパミン / 錐体細胞 / 樹状突起 |
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| Outline of Final Research Achievements |
The frontal cortex (FC) is an important brain region for motor function as well as decision making and social or cognitive behavior. Here we show the organizing molecule, fibroblast growth factor 8 (Fgf8), has an effect to medialize the dorsal part of the FC. We analyzed expression of FC subdivision markers in Fgf8-transfected mouse brains. When Fgf8 was misexpressed in the anterior pole of the telencephalon by in vivo electroporation, the dorsomedial part of the FC (anterior cingulate and prelimbic cortex) was expanded. Expression borders of dorsal FC subdivision markers shifted laterally. We also found that the morphology of the Fgf8-transfected brains was quite abnormal: the ventral FC (the orbital cortex) was not formed and the olfactory bulb was larger than that of wild-type brains. These findings suggest that Fgf8 is involved in the formation of FC subdivision and olfactory bulb development.
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] Targeted disruption of the mouse protein phosphatase ppm1l gene leads to structural abnormalities in the brain.2016
Author(s)
Kusano, R., Kousuke Fujita, K., Yasuharu Shinoda, Y., Nagaura, Y., Kiyonari, H., Abe, T, Watanabe, T., Matsui, Y., Fukaya, M., Sakagami, H., Sato, T., Funahashi, J.-I., Ohnishi, M., Tamura, S., Kobayashi, T.
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Journal Title
FEBS Letters
Volume: 590
Issue: 20
Pages: 3603-3615
DOI
Related Report
Peer Reviewed
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[Presentation] Sex differences of CRF-expressing neurons in the bed nucleus of the stria terminalis of the mouse2017
Author(s)
Hiroko Otsuka, Katsuya Uchida, Masahiro Morisita, Shinji Tsukahara, Toshimitsu Fuse, Yuto Kagotani, Satoshi Yamagata, Tatsuya Sato, Manabu Abe, Kenji Sakimura, Keiichi Itoi
Organizer
The 2017 Japan-NIH joint Symposium on Advances in Biomedical Research and Disease
Place of Presentation
仙台
Year and Date
2017-02-16
Related Report
Int'l Joint Research
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