• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Correlation between emotional change during pregnant and postpartum period and neuronal structure in the amygdala

Research Project

Project/Area Number 26430038
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Nerve anatomy/Neuropathology
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

Matsuda Ken Ichi  京都府立医科大学, 医学(系)研究科(研究院), 准教授 (40315932)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsエストロゲン / 脳 / 情動 / 扁桃体 / 分界条床核 / 妊娠 / 出産
Outline of Final Research Achievements

In peripartum period, women tend to exhibit emotional instability. The ovarian steroid hormone environment is drastically changed during these periods, and this hormonal change may be an important cause of peripartum emotional instability. The amygdala and the bed nucleus of the stria terminalis (BNST) is involved in the emotional response. In this research, change of the neuronal morphology in the central (CeA) and basolateral (BLA) nucleus of the amygdala and BNST was examined at mid- and late-gestation and early postpartum in rat. The dendritic spine density in the CeA, BLA and BNST was significantly decreased at early postpartum, compared with gestations. These results provide fundamental insights into the neuronal basis underlying emotional instability during pregnancy and postpartum. To examine molecular mechanism of these phenomena, global gene expression analysis was performed. It was found that gene expression profile was dramatically altered during peripartum period.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (35 results)

All 2017 2016 2015 2014

All Journal Article (12 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 12 results,  Open Access: 11 results,  Acknowledgement Compliant: 5 results) Presentation (23 results) (of which Invited: 8 results)

  • [Journal Article] Depressive-like behaviors are regulated by NOX1/NADPH oxidase by redox modification of NMDA receptor 1.2017

    • Author(s)
      Ibi M, Liu J, Arakawa N, Kitaoka S, Kawaji A, Matsuda KI, Iwata K, Matsumoto M, Katsuyama M, Zhu K, Teramukai S, Furuyashiki T, Yabe-Nishimura C.
    • Journal Title

      J Neurosci

      Volume: 37 Issue: 15 Pages: 4200-4212

    • DOI

      10.1523/jneurosci.2988-16.2017

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Decrease in neuronal spine density in the postpartum period in the amygdala and bed nucleus of the stria terminalis in rat2017

    • Author(s)
      S Matsuo, KI Matsuda, K Takanami, T Mori, M Tanaka, M Kawata, J Kitawaki
    • Journal Title

      Neuroscience Letters

      Volume: 641 Pages: 21-25

    • DOI

      10.1016/j.neulet.2017.01.040

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Immunohistochemical profiling of estrogen-related receptor gamma in rat brain and colocalization with estrogen receptor alpha in the preoptic area.2017

    • Author(s)
      Tanida T, Matsuda KI, Yamada S, Kawata M, Tanaka M.
    • Journal Title

      Brain Res

      Volume: 1659 Pages: 71-80

    • DOI

      10.1016/j.brainres.2017.01.024

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A Sexually Dimorphic Area of the Dorsal Hypothalamus in Mice and Common Marmosets.2016

    • Author(s)
      Moe, Y., Kyi-Tha-Thu, C., Tanaka, T., Ito, H., Yahashi, S., Matsuda, K., Kawata, M., Katsuura, G., Iwashige, F., Sakata, I., Akune, A., Inui, A., Sakai, T., Ogawa, S., and Tsukahara, S.
    • Journal Title

      Endocrinology

      Volume: 157 Issue: 12 Pages: 4817-4828

    • DOI

      10.1210/en.2016-1428

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Differential responses to steroid hormones in fibroblasts from the vocal fold, trachea, and esophagus.2015

    • Author(s)
      Mukudai S, Matsuda K I, Nishio T, Sugiyama Y, Bando H, Hirota R, Sakaguchi H, Hisa Y, Kawata M
    • Journal Title

      Endocrinology

      Volume: 156 Issue: 3 Pages: 1000-1009

    • DOI

      10.1210/en.2014-1605

    • Related Report
      2016 Annual Research Report 2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Critical role of androgen receptor in the postnatal period in male sexual behavior in rats.2015

    • Author(s)
      Yamada S, Ooya M, Takanami K, Matsuda KI, Kawata M.
    • Journal Title

      Neuroscience Letters

      Volume: 609 Pages: 189-93

    • DOI

      10.1016/j.neulet.2015.10.040

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Sex differences in cells expressing green fluorescent protein under the control of the estrogen receptor  promoter in the hypothalamus of mice.2015

    • Author(s)
      Kyi Tha Thu C, Okoshi K, Ito H, Matsuda KI, Kawata M, Tsukahara S.
    • Journal Title

      Neuroscience Research

      Volume: 101 Pages: 44-52

    • DOI

      10.1016/j.neures.2015.07.006

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Stimulation of rotator cuff repair by sustained release of bone morphogenetic protein-7 using a gelatin hydrogel sheet.2015

    • Author(s)
      Kabuto Y, Morihara T, Sukeneri T, Kida Y, Oda R, Arai Y, Sawada K, Matsuda KI, Kawata M, Tabata Y, Fujiwara H, Kubo T.
    • Journal Title

      Tissue Engineering

      Volume: 21 Issue: 13-14 Pages: 2025-2033

    • DOI

      10.1089/ten.tea.2014.0541

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Estrogen-Related Receptor beta Reduces the Subnuclear Mobility of Estrogen Receptor alpha and Suppresses Estrogen-Dependent Cellular Function.2015

    • Author(s)
      Tanida T, Matsuda K I, Yamada S, Hashimoto T, Kawata M
    • Journal Title

      J Biol Chem

      Volume: - Issue: 19 Pages: 12332-12345

    • DOI

      10.1074/jbc.m114.619098

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Bisphenol A regulates the estrogen receptor alpha signaling in developing hippocampus of male rats through estrogen receptor.2014

    • Author(s)
      Xu X B, He Y, Song C, Ke X, Fan S J, Peng W J, Tan R, Kawata M, Matsuda K, Pan B X, Kato N
    • Journal Title

      Hippocampus

      Volume: 24 Issue: 12 Pages: 1570-1580

    • DOI

      10.1002/hipo.22336

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Estrogenic regulation of histamine receptor subtype H1 expression in ventromedial nucleus of the hypothalamus in female rats.2014

    • Author(s)
      Mori H., Matsuda K. I., Yamawaki M., Kawata M.
    • Journal Title

      PLoS One

      Volume: 印刷中 Issue: 5 Pages: 96232-96232

    • DOI

      10.1371/journal.pone.0096232

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Epigenetic changes in the estrogen receptor alpha gene promoter: implications in sociosexual behaviors2014

    • Author(s)
      Matsuda KI
    • Journal Title

      Frontiers in Neuroscience

      Volume: 8 Pages: 344-344

    • DOI

      10.3389/fnins.2014.00344

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Expression of c-Fos in Sagittalis Nucleus of the Hypothalamus after Ovarian Steroid Hormone Manipulation in Female Rat2017

    • Author(s)
      Ivaylo Balabanov、松田賢一、山田俊児、田中雅樹
    • Organizer
      第122回日本解剖学会
    • Place of Presentation
      長崎
    • Year and Date
      2017-03-29
    • Related Report
      2016 Annual Research Report
  • [Presentation] 好気性代謝制御因子PGC-1alphaのスプライシングバリアントPGCvfの細胞内動態と転写調節機構2017

    • Author(s)
      谷田任司、松田賢一、山田俊児、河田光博、田中雅樹
    • Organizer
      第122回日本解剖学会
    • Place of Presentation
      長崎
    • Year and Date
      2017-03-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] Epigenetics in the Sexual Behavior Center of the Rat2016

    • Author(s)
      松田賢一
    • Organizer
      第87回日本動物学会
    • Place of Presentation
      沖縄
    • Year and Date
      2016-11-17
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] The Year 基礎編2016

    • Author(s)
      松田賢一
    • Organizer
      第43回日本神経内分泌学会
    • Place of Presentation
      浜松
    • Year and Date
      2016-10-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] 雄の性機能を司る脊髄神経回路系の機能解析2016

    • Author(s)
      越智拓海、高浪景子、松田賢一、河田光博、坂本竜哉、坂本浩隆
    • Organizer
      第43回日本神経内分泌学会
    • Place of Presentation
      浜松
    • Year and Date
      2016-10-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] 授乳期における弓状核Kiss1遺伝子制御メカニズムの解明2016

    • Author(s)
      山田俊児、杉本有紗、上野山賀久、松田賢一、河田光博、束村博子、田中雅樹
    • Organizer
      第43回日本神経内分泌学会
    • Place of Presentation
      浜松
    • Year and Date
      2016-10-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] 中枢神経系におけるエストロゲン・プロゲストーゲンのクロストーク2016

    • Author(s)
      松田賢一
    • Organizer
      第5回プロゲストーゲン研究会
    • Place of Presentation
      東京
    • Year and Date
      2016-06-04
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] かたちの意味-精到な神経組織観察から機能へ-2016

    • Author(s)
      松田賢一
    • Organizer
      第121回日本解剖学会
    • Place of Presentation
      郡山
    • Year and Date
      2016-03-30
    • Related Report
      2015 Research-status Report
  • [Presentation] 形態学解析から考える痒みの伝達機構2016

    • Author(s)
      高浪景子、松田賢一、河田光博、坂本竜哉、坂本浩隆
    • Organizer
      第121回日本解剖学会
    • Place of Presentation
      郡山
    • Year and Date
      2016-03-30
    • Related Report
      2015 Research-status Report
  • [Presentation] PTSDモデルラットのストレス負荷に伴う脳内CRHの発現変動2016

    • Author(s)
      橋本隆、松田賢一、吉井崇喜、河田光博、飯野哲
    • Organizer
      第121回日本解剖学会
    • Place of Presentation
      郡山
    • Year and Date
      2016-03-30
    • Related Report
      2015 Research-status Report
  • [Presentation] 好気的エネルギー代謝制御因子PGC-1/ERRの細胞内動態2016

    • Author(s)
      谷田任司、松田賢一、山田俊児、河田光博
    • Organizer
      第121回日本解剖学会
    • Place of Presentation
      郡山
    • Year and Date
      2016-03-29
    • Related Report
      2015 Research-status Report
  • [Presentation] 声帯、気管および食道粘膜下線維芽細胞におけるステロイドホルモン受容体の発現と機能2015

    • Author(s)
      椋代茂之、松田賢一、久育男、河田光博
    • Organizer
      第56回日本組織細胞化学会
    • Place of Presentation
      大阪
    • Year and Date
      2015-10-03
    • Related Report
      2015 Research-status Report
  • [Presentation] 片側乳頭結紮による神経伝達阻害が授乳ラットの脳に及ぼす影響2015

    • Author(s)
      山田俊児、谷田任司、松田賢一、河田光博
    • Organizer
      第56回日本組織細胞化学会
    • Place of Presentation
      大阪
    • Year and Date
      2015-10-03
    • Related Report
      2015 Research-status Report
  • [Presentation] エストロゲン受容体とエストロゲン関連受容体によるエストロゲンシグナル共調節機構2015

    • Author(s)
      谷田任司、松田賢一、山田俊児、橋下隆、河田光博
    • Organizer
      第42回日本神経内分泌学会 第23回日本行動神経内分泌研究会 合同大会
    • Place of Presentation
      仙台
    • Year and Date
      2015-09-19
    • Related Report
      2015 Research-status Report
  • [Presentation] エピジェネティクス解析の基礎と組織細胞化学への応用2015

    • Author(s)
      松田賢一、井上敏昭、森浩子、橋本隆、河田光博
    • Organizer
      第40回日本組織細胞化学会講習会
    • Place of Presentation
      東京
    • Year and Date
      2015-08-05
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] エストロゲン受容体陽性ニューロン-形態から分子まで-2015

    • Author(s)
      松田賢一
    • Organizer
      第88回日本内分泌学会
    • Place of Presentation
      東京
    • Year and Date
      2015-04-24
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] エストロゲン受容体陽性ニューロン2015

    • Author(s)
      松田賢一
    • Organizer
      第88回日本内分泌学会
    • Place of Presentation
      東京
    • Year and Date
      2015-04-24
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 妊娠分娩中のホルモン環境変化が扁桃体におけるエストロゲン受容体α発現と神経形態に及ぼす影響2015

    • Author(s)
      松尾精記、松田賢一、北脇城、河田光博、他
    • Organizer
      第120回日本解剖学会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-23
    • Related Report
      2014 Research-status Report
  • [Presentation] 幼若期のアンドロゲン受容体阻害剤投与が中枢神経の雄性化に与える影響2014

    • Author(s)
      松田賢一
    • Organizer
      第14回日本Men’s Health医学会・第5回テストステロン研究会
    • Place of Presentation
      大阪
    • Year and Date
      2014-09-27
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 妊娠分娩を通じたホルモン環境変化が扁桃体におけるエストロゲン受容体αの発現変化と神経細胞形態に与える影響の検討2014

    • Author(s)
      松尾精記、松田賢一、北脇城、河田光博
    • Organizer
      第37回日本神経科学会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-13
    • Related Report
      2014 Research-status Report
  • [Presentation] 妊娠分娩に伴う扁桃体でのエストロゲン受容体α発現と神経形態の変化2014

    • Author(s)
      松尾精記、松田賢一、北脇城、河田光博
    • Organizer
      第21回日本行動神経内分泌研究会
    • Place of Presentation
      秩父
    • Year and Date
      2014-09-04
    • Related Report
      2014 Research-status Report
  • [Presentation] Estrogen Receptor alpha in the Brain: Genetic and Epigenetic Approaches2014

    • Author(s)
      Matsuda KI
    • Organizer
      Satellite Meeting of ICN2014
    • Place of Presentation
      シドニー
    • Year and Date
      2014-08-16
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] エピジェネティックスと組織細胞化学2014

    • Author(s)
      松田賢一
    • Organizer
      第39回日本組織細胞化学会講習会
    • Place of Presentation
      大津
    • Year and Date
      2014-08-06
    • Related Report
      2014 Research-status Report
    • Invited

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi