Correlation between emotional change during pregnant and postpartum period and neuronal structure in the amygdala

• Project/Area Number: 26430038
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: Matsuda Ken Ichi 京都府立医科大学, 医学(系)研究科(研究院), 准教授 (40315932)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: エストロゲン / 脳 / 情動 / 扁桃体 / 分界条床核 / 妊娠 / 出産

Outline of Final Research Achievements

In peripartum period, women tend to exhibit emotional instability. The ovarian steroid hormone environment is drastically changed during these periods, and this hormonal change may be an important cause of peripartum emotional instability. The amygdala and the bed nucleus of the stria terminalis (BNST) is involved in the emotional response. In this research, change of the neuronal morphology in the central (CeA) and basolateral (BLA) nucleus of the amygdala and BNST was examined at mid- and late-gestation and early postpartum in rat. The dendritic spine density in the CeA, BLA and BNST was significantly decreased at early postpartum, compared with gestations. These results provide fundamental insights into the neuronal basis underlying emotional instability during pregnancy and postpartum. To examine molecular mechanism of these phenomena, global gene expression analysis was performed. It was found that gene expression profile was dramatically altered during peripartum period.

Research Products

• [Journal Article] Depressive-like behaviors are regulated by NOX1/NADPH oxidase by redox modification of NMDA receptor 1. (2017)
  • Author(s): Ibi M, Liu J, Arakawa N, Kitaoka S, Kawaji A, Matsuda KI, Iwata K, Matsumoto M, Katsuyama M, Zhu K, Teramukai S, Furuyashiki T, Yabe-Nishimura C.
  • Journal Title: J Neurosci Volume: 37 Issue: 15 Pages: 4200-4212
  • DOI: 10.1523/jneurosci.2988-16.2017
  • Peer Reviewed / Open Access
• [Journal Article] Decrease in neuronal spine density in the postpartum period in the amygdala and bed nucleus of the stria terminalis in rat (2017)
  • Author(s): S Matsuo, KI Matsuda, K Takanami, T Mori, M Tanaka, M Kawata, J Kitawaki
  • Journal Title: Neuroscience Letters Volume: 641 Pages: 21-25
  • DOI: 10.1016/j.neulet.2017.01.040
  • Peer Reviewed / Open Access
• [Journal Article] Immunohistochemical profiling of estrogen-related receptor gamma in rat brain and colocalization with estrogen receptor alpha in the preoptic area. (2017)
  • Author(s): Tanida T, Matsuda KI, Yamada S, Kawata M, Tanaka M.
  • Journal Title: Brain Res Volume: 1659 Pages: 71-80
  • DOI: 10.1016/j.brainres.2017.01.024
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A Sexually Dimorphic Area of the Dorsal Hypothalamus in Mice and Common Marmosets. (2016)
  • Author(s): Moe, Y., Kyi-Tha-Thu, C., Tanaka, T., Ito, H., Yahashi, S., Matsuda, K., Kawata, M., Katsuura, G., Iwashige, F., Sakata, I., Akune, A., Inui, A., Sakai, T., Ogawa, S., and Tsukahara, S.
  • Journal Title: Endocrinology Volume: 157 Issue: 12 Pages: 4817-4828
  • DOI: 10.1210/en.2016-1428
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Differential responses to steroid hormones in fibroblasts from the vocal fold, trachea, and esophagus. (2015)
  • Author(s): Mukudai S, Matsuda K I, Nishio T, Sugiyama Y, Bando H, Hirota R, Sakaguchi H, Hisa Y, Kawata M
  • Journal Title: Endocrinology Volume: 156 Issue: 3 Pages: 1000-1009
  • DOI: 10.1210/en.2014-1605
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Critical role of androgen receptor in the postnatal period in male sexual behavior in rats. (2015)
  • Author(s): Yamada S, Ooya M, Takanami K, Matsuda KI, Kawata M.
  • Journal Title: Neuroscience Letters Volume: 609 Pages: 189-93
  • DOI: 10.1016/j.neulet.2015.10.040
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Sex differences in cells expressing green fluorescent protein under the control of the estrogen receptor  promoter in the hypothalamus of mice. (2015)
  • Author(s): Kyi Tha Thu C, Okoshi K, Ito H, Matsuda KI, Kawata M, Tsukahara S.
  • Journal Title: Neuroscience Research Volume: 101 Pages: 44-52
  • DOI: 10.1016/j.neures.2015.07.006
  • Peer Reviewed / Open Access
• [Journal Article] Stimulation of rotator cuff repair by sustained release of bone morphogenetic protein-7 using a gelatin hydrogel sheet. (2015)
  • Author(s): Kabuto Y, Morihara T, Sukeneri T, Kida Y, Oda R, Arai Y, Sawada K, Matsuda KI, Kawata M, Tabata Y, Fujiwara H, Kubo T.
  • Journal Title: Tissue Engineering Volume: 21 Issue: 13-14 Pages: 2025-2033
  • DOI: 10.1089/ten.tea.2014.0541
  • Peer Reviewed / Open Access
• [Journal Article] Estrogen-Related Receptor beta Reduces the Subnuclear Mobility of Estrogen Receptor alpha and Suppresses Estrogen-Dependent Cellular Function. (2015)
  • Author(s): Tanida T, Matsuda K I, Yamada S, Hashimoto T, Kawata M
  • Journal Title: J Biol Chem Volume: - Issue: 19 Pages: 12332-12345
  • DOI: 10.1074/jbc.m114.619098
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Bisphenol A regulates the estrogen receptor alpha signaling in developing hippocampus of male rats through estrogen receptor. (2014)
  • Author(s): Xu X B, He Y, Song C, Ke X, Fan S J, Peng W J, Tan R, Kawata M, Matsuda K, Pan B X, Kato N
  • Journal Title: Hippocampus Volume: 24 Issue: 12 Pages: 1570-1580
  • DOI: 10.1002/hipo.22336
  • Peer Reviewed
• [Journal Article] Estrogenic regulation of histamine receptor subtype H1 expression in ventromedial nucleus of the hypothalamus in female rats. (2014)
  • Author(s): Mori H., Matsuda K. I., Yamawaki M., Kawata M.
  • Journal Title: PLoS One Volume: 印刷中 Issue: 5 Pages: 96232-96232
  • DOI: 10.1371/journal.pone.0096232
  • Peer Reviewed / Open Access
• [Journal Article] Epigenetic changes in the estrogen receptor alpha gene promoter: implications in sociosexual behaviors (2014)
  • Author(s): Matsuda KI
  • Journal Title: Frontiers in Neuroscience Volume: 8 Pages: 344-344
  • DOI: 10.3389/fnins.2014.00344
  • Peer Reviewed / Open Access
• [Presentation] Expression of c-Fos in Sagittalis Nucleus of the Hypothalamus after Ovarian Steroid Hormone Manipulation in Female Rat (2017)
  • Author(s): Ivaylo Balabanov、松田賢一、山田俊児、田中雅樹
  • Organizer: 第122回日本解剖学会
  • Place of Presentation: 長崎
  • Year and Date: 2017-03-29
• [Presentation] 好気性代謝制御因子PGC-1alphaのスプライシングバリアントPGCvfの細胞内動態と転写調節機構 (2017)
  • Author(s): 谷田任司、松田賢一、山田俊児、河田光博、田中雅樹
  • Organizer: 第122回日本解剖学会
  • Place of Presentation: 長崎
  • Year and Date: 2017-03-28
• [Presentation] Epigenetics in the Sexual Behavior Center of the Rat (2016)
  • Author(s): 松田賢一
  • Organizer: 第87回日本動物学会
  • Place of Presentation: 沖縄
  • Year and Date: 2016-11-17
  • Invited
• [Presentation] The Year 基礎編 (2016)
  • Author(s): 松田賢一
  • Organizer: 第43回日本神経内分泌学会
  • Place of Presentation: 浜松
  • Year and Date: 2016-10-15
• [Presentation] 雄の性機能を司る脊髄神経回路系の機能解析 (2016)
  • Author(s): 越智拓海、高浪景子、松田賢一、河田光博、坂本竜哉、坂本浩隆
  • Organizer: 第43回日本神経内分泌学会
  • Place of Presentation: 浜松
  • Year and Date: 2016-10-14
• [Presentation] 授乳期における弓状核Kiss1遺伝子制御メカニズムの解明 (2016)
  • Author(s): 山田俊児、杉本有紗、上野山賀久、松田賢一、河田光博、束村博子、田中雅樹
  • Organizer: 第43回日本神経内分泌学会
  • Place of Presentation: 浜松
  • Year and Date: 2016-10-14
• [Presentation] 中枢神経系におけるエストロゲン・プロゲストーゲンのクロストーク (2016)
  • Author(s): 松田賢一
  • Organizer: 第5回プロゲストーゲン研究会
  • Place of Presentation: 東京
  • Year and Date: 2016-06-04
  • Invited
• [Presentation] かたちの意味－精到な神経組織観察から機能へ－ (2016)
  • Author(s): 松田賢一
  • Organizer: 第121回日本解剖学会
  • Place of Presentation: 郡山
  • Year and Date: 2016-03-30
• [Presentation] 形態学解析から考える痒みの伝達機構 (2016)
  • Author(s): 高浪景子、松田賢一、河田光博、坂本竜哉、坂本浩隆
  • Organizer: 第121回日本解剖学会
  • Place of Presentation: 郡山
  • Year and Date: 2016-03-30
• [Presentation] PTSDモデルラットのストレス負荷に伴う脳内CRHの発現変動 (2016)
  • Author(s): 橋本隆、松田賢一、吉井崇喜、河田光博、飯野哲
  • Organizer: 第121回日本解剖学会
  • Place of Presentation: 郡山
  • Year and Date: 2016-03-30
• [Presentation] 好気的エネルギー代謝制御因子PGC-1/ERRの細胞内動態 (2016)
  • Author(s): 谷田任司、松田賢一、山田俊児、河田光博
  • Organizer: 第121回日本解剖学会
  • Place of Presentation: 郡山
  • Year and Date: 2016-03-29
• [Presentation] 声帯、気管および食道粘膜下線維芽細胞におけるステロイドホルモン受容体の発現と機能 (2015)
  • Author(s): 椋代茂之、松田賢一、久育男、河田光博
  • Organizer: 第56回日本組織細胞化学会
  • Place of Presentation: 大阪
  • Year and Date: 2015-10-03
• [Presentation] 片側乳頭結紮による神経伝達阻害が授乳ラットの脳に及ぼす影響 (2015)
  • Author(s): 山田俊児、谷田任司、松田賢一、河田光博
  • Organizer: 第56回日本組織細胞化学会
  • Place of Presentation: 大阪
  • Year and Date: 2015-10-03
• [Presentation] エストロゲン受容体とエストロゲン関連受容体によるエストロゲンシグナル共調節機構 (2015)
  • Author(s): 谷田任司、松田賢一、山田俊児、橋下隆、河田光博
  • Organizer: 第42回日本神経内分泌学会 第23回日本行動神経内分泌研究会 合同大会
  • Place of Presentation: 仙台
  • Year and Date: 2015-09-19
• [Presentation] エピジェネティクス解析の基礎と組織細胞化学への応用 (2015)
  • Author(s): 松田賢一、井上敏昭、森浩子、橋本隆、河田光博
  • Organizer: 第40回日本組織細胞化学会講習会
  • Place of Presentation: 東京
  • Year and Date: 2015-08-05
  • Invited
• [Presentation] エストロゲン受容体陽性ニューロン－形態から分子まで－ (2015)
  • Author(s): 松田賢一
  • Organizer: 第88回日本内分泌学会
  • Place of Presentation: 東京
  • Year and Date: 2015-04-24
  • Invited
• [Presentation] エストロゲン受容体陽性ニューロン (2015)
  • Author(s): 松田賢一
  • Organizer: 第88回日本内分泌学会
  • Place of Presentation: 東京
  • Year and Date: 2015-04-24
  • Invited
• [Presentation] 妊娠分娩中のホルモン環境変化が扁桃体におけるエストロゲン受容体α発現と神経形態に及ぼす影響 (2015)
  • Author(s): 松尾精記、松田賢一、北脇城、河田光博、他
  • Organizer: 第120回日本解剖学会
  • Place of Presentation: 神戸
  • Year and Date: 2015-03-23
• [Presentation] 幼若期のアンドロゲン受容体阻害剤投与が中枢神経の雄性化に与える影響 (2014)
  • Author(s): 松田賢一
  • Organizer: 第14回日本Men’s Health医学会・第5回テストステロン研究会
  • Place of Presentation: 大阪
  • Year and Date: 2014-09-27
  • Invited
• [Presentation] 妊娠分娩を通じたホルモン環境変化が扁桃体におけるエストロゲン受容体αの発現変化と神経細胞形態に与える影響の検討 (2014)
  • Author(s): 松尾精記、松田賢一、北脇城、河田光博
  • Organizer: 第37回日本神経科学会
  • Place of Presentation: 横浜
  • Year and Date: 2014-09-13
• [Presentation] 妊娠分娩に伴う扁桃体でのエストロゲン受容体α発現と神経形態の変化 (2014)
  • Author(s): 松尾精記、松田賢一、北脇城、河田光博
  • Organizer: 第21回日本行動神経内分泌研究会
  • Place of Presentation: 秩父
  • Year and Date: 2014-09-04
• [Presentation] Estrogen Receptor alpha in the Brain: Genetic and Epigenetic Approaches (2014)
  • Author(s): Matsuda KI
  • Organizer: Satellite Meeting of ICN2014
  • Place of Presentation: シドニー
  • Year and Date: 2014-08-16
  • Invited
• [Presentation] エピジェネティックスと組織細胞化学 (2014)
  • Author(s): 松田賢一
  • Organizer: 第39回日本組織細胞化学会講習会
  • Place of Presentation: 大津
  • Year and Date: 2014-08-06
  • Invited