Correlation between emotional change during pregnant and postpartum period and neuronal structure in the amygdala
Project/Area Number |
26430038
|
Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Nerve anatomy/Neuropathology
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Research Institution | Kyoto Prefectural University of Medicine |
Principal Investigator |
Matsuda Ken Ichi 京都府立医科大学, 医学(系)研究科(研究院), 准教授 (40315932)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | エストロゲン / 脳 / 情動 / 扁桃体 / 分界条床核 / 妊娠 / 出産 |
Outline of Final Research Achievements |
In peripartum period, women tend to exhibit emotional instability. The ovarian steroid hormone environment is drastically changed during these periods, and this hormonal change may be an important cause of peripartum emotional instability. The amygdala and the bed nucleus of the stria terminalis (BNST) is involved in the emotional response. In this research, change of the neuronal morphology in the central (CeA) and basolateral (BLA) nucleus of the amygdala and BNST was examined at mid- and late-gestation and early postpartum in rat. The dendritic spine density in the CeA, BLA and BNST was significantly decreased at early postpartum, compared with gestations. These results provide fundamental insights into the neuronal basis underlying emotional instability during pregnancy and postpartum. To examine molecular mechanism of these phenomena, global gene expression analysis was performed. It was found that gene expression profile was dramatically altered during peripartum period.
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Report
(4 results)
Research Products
(35 results)
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[Journal Article] Depressive-like behaviors are regulated by NOX1/NADPH oxidase by redox modification of NMDA receptor 1.2017
Author(s)
Ibi M, Liu J, Arakawa N, Kitaoka S, Kawaji A, Matsuda KI, Iwata K, Matsumoto M, Katsuyama M, Zhu K, Teramukai S, Furuyashiki T, Yabe-Nishimura C.
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Journal Title
J Neurosci
Volume: 37
Issue: 15
Pages: 4200-4212
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] A Sexually Dimorphic Area of the Dorsal Hypothalamus in Mice and Common Marmosets.2016
Author(s)
Moe, Y., Kyi-Tha-Thu, C., Tanaka, T., Ito, H., Yahashi, S., Matsuda, K., Kawata, M., Katsuura, G., Iwashige, F., Sakata, I., Akune, A., Inui, A., Sakai, T., Ogawa, S., and Tsukahara, S.
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Journal Title
Endocrinology
Volume: 157
Issue: 12
Pages: 4817-4828
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Differential responses to steroid hormones in fibroblasts from the vocal fold, trachea, and esophagus.2015
Author(s)
Mukudai S, Matsuda K I, Nishio T, Sugiyama Y, Bando H, Hirota R, Sakaguchi H, Hisa Y, Kawata M
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Journal Title
Endocrinology
Volume: 156
Issue: 3
Pages: 1000-1009
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Stimulation of rotator cuff repair by sustained release of bone morphogenetic protein-7 using a gelatin hydrogel sheet.2015
Author(s)
Kabuto Y, Morihara T, Sukeneri T, Kida Y, Oda R, Arai Y, Sawada K, Matsuda KI, Kawata M, Tabata Y, Fujiwara H, Kubo T.
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Journal Title
Tissue Engineering
Volume: 21
Issue: 13-14
Pages: 2025-2033
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Bisphenol A regulates the estrogen receptor alpha signaling in developing hippocampus of male rats through estrogen receptor.2014
Author(s)
Xu X B, He Y, Song C, Ke X, Fan S J, Peng W J, Tan R, Kawata M, Matsuda K, Pan B X, Kato N
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Journal Title
Hippocampus
Volume: 24
Issue: 12
Pages: 1570-1580
DOI
Related Report
Peer Reviewed
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