| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
In the present study, I focused on BRAG1, one of the excitatory postsynaptic molecules, which causes nonsyndromic mental retardation in human. To reveal the functional mechanisms of BRAG1 at postsynapse, BRAG1 knockout mice were generated. Using BRAG1 knockout mice, many neuronal and glial marker molecules were screened by immunoblot and immunohistochemical assays. Consequently, loss of BRAG1 was accompanied by upregulation of some glutamate receptor subunits in the hippocampus, and impairment of the passive avoidance task. These results suggest that BRAG1 plays important roles in the regulation of the glutamate receptor localization at excitatory post synapse and hippocampus-dependent memory.
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