| Project/Area Number |
26430044
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Mukogawa Women's University (2015-2016)
Fujita Health University (2014) |
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Principal Investigator |
Ohira Koji 武庫川女子大学, 生活環境学部, 准教授 (80402832)
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| Co-Investigator(Renkei-kenkyūsha) |
Miyakawa Tsuyoshi 藤田保健衛生大学, 総合医科学研究所, 教授 (10301780)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 成体神経新生 / 抑制性神経細胞 / 大脳皮質 / 神経保護 / 再生医療 / 神経前駆細胞 / 脳由来神経栄養因子 / 分子機構 / 老化 / 電子顕微鏡 |
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| Outline of Final Research Achievements |
We have found the neural progenitor cells, L1-INP cells, in the adult cortex. In this study, we further analyzed L1-INP cells, using neuroanatomical methods. First, we determined the protocols for 3D-SEM analysis of L1-INP cells. Second, we found that the density of L1-INP cells was kept from 5- to 12-month-old, dramatically decreased at 17-month-old, and thereafter maintained the same level until 24-month-old. Additionally, the degrees of decreased densities of NPCs in the cingulate and insular cortices were significantly smaller than those in the primary motor and somatosensory cortices. Finally, we made anti-TrkB-T1, which is
useful for studying the mechanism underlying adult neurogenesis of L1-INP cells. We obtained antiserum for TrkB-T1 in one out of three guinia pigs.
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