Study of the function of FILIP on the neuron morphology

• Project/Area Number: 26430045
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: Hyogo Medical University
• Principal Investigator: Yagi Hideshi 兵庫医科大学, 医学部, 教授 (10303372)
• Co-Investigator(Kenkyū-buntansha): 佐藤 真 大阪大学, 連合小児発達学研究科, 教授 (10222019)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: ミオシン / アクチン / 神経細胞 / 神経突起 / 細胞骨格 / 細胞外マトリックス

Outline of Final Research Achievements

We investigated the mechanism of morphological control of neurons that have an essential role in the function of the nervous system. FILIP which expression is observed in the central nervous system and spinal ganglia controls neuronal cell morphology through the control of intracellular distribution of non-muscle myosin IIB. In this study, we revealed that the function of Hsc70 was indispensable for the control mechanism of non-muscle myosin IIB via FILIP. We also revealed that the function of Hsc70 was involved in the function of FILIP that controls neuronal morphology.

Research Products

• [Journal Article] Subcellular distribution of non-muscle myosin IIb is controlled by FILIP through Hsc70. (2017)
  • Author(s): Yagi H, Takabayashi T, Xie MJ, Kuroda K, Sato M
  • Journal Title: PLOS ONE Volume: 12 Issue: 2 Pages: e0172257-e0172257
  • DOI: 10.1371/journal.pone.0172257
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] 細胞骨格の調整による神経細胞の形態制御機構 (2016)
  • Author(s): 八木秀司
  • Organizer: 第130回 関西実験動物研究会
  • Place of Presentation: 神戸大学医学部(兵庫県神戸市)
  • Invited
• [Presentation] Deletion of FILIP influenced the development of peripheral nerve (2015)
  • Author(s): Hideshi Yagi，Hirosato Kanda，Koichi Noguchi，Makoto Sato
  • Organizer: 第58回 日本神経化学会大会
  • Place of Presentation: 大宮ソニックシティ（埼玉県さいたま市）
  • Year and Date: 2015-09-13