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Globular glial tauopathy: investigation of the pathological features

Research Project

Project/Area Number 26430052
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Nerve anatomy/Neuropathology
Research InstitutionNiigata University

Principal Investigator

TOYOSHIMA Yasuko  新潟大学, 脳研究所, 准教授 (20334675)

Co-Investigator(Kenkyū-buntansha) 池内 健  新潟大学, 脳研究所, 教授 (20372469)
他田 真理  新潟大学, 脳研究所, 助教 (30646394)
高橋 均  新潟大学, 脳研究所, 教授 (90206839)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsタウオパチー / アストロサイト / globular glial tauopathy / オリゴマー / 神経変性疾患 / ピック病 / タウオリゴマー / 進行性核上性麻痺
Outline of Final Research Achievements

We examined the brains of GGT-type III, using an anti-tau oligomer-specific polyclonal antibody, T22 and anti-phosphorylated tau antibody, AT8. Predominant occurrence of GAIs was also confirmed with AT8 and T22. We consider that GGT are different from other 4R tauopathies not only in their pathological picture but also in their constituent tau species. It is tempting to speculate that GAIs represent a distinct, 4R tau-oligomer astrocytopathy that characterizes GGT.
We also performed a pathological and clinical investigation in 40 consecutive autopsied patients with pathological diagnoses of PSP-related disease. Unequivocal TAs were present in 22 cases, all of which were confirmed to be PSP. Such TAs were hardly observed in the other 18 cases. Cluster analysis of the distribution pattern of tau-related pathology for these 18 cases identified two subgroups, pallido-nigro-luysian atrophy (PNLA) Type 1 (n = 9) and Type 2 (n = 9).

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (11 results)

All 2017 2016 2015 2014

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Acknowledgement Compliant: 2 results) Presentation (9 results) (of which Int'l Joint Research: 5 results)

  • [Journal Article] Globular Glial Mixed Four Repeat Tau and TDP-43 Proteinopathy with Motor Neuron Disease and Frontotemporal Dementia2015

    • Author(s)
      Takeuchi R, Toyoshima Y, Tada M, Tanaka H, Shimizu H, Shiga A, Miura T, Aoki K, Aikawa A, Ishizawa S, Ikeuchi T, Nishizawa M, Kakita A, Takahashi H
    • Journal Title

      Brain Pathology

      Volume: 印刷中

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Pathological and Clinical Spectrum of Progressive Supranuclear Palsy: with Special Reference to Astrocytic Tau Pathology2015

    • Author(s)
      Yokoyama Y, Toyoshima Y, Shiga A, Tada M, Kitamura H, Hasegawa K, Onodera O, Ikeuchi T, Someya T, Nishizawa M, Kakita A, Takahashi H
    • Journal Title

      Brain Pathology

      Volume: 印刷中

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Globular glial tauopathy: characteristic histologic features of an autopsied patient with its type II2017

    • Author(s)
      Tanaka H, Toyoshima Y, Tada M, Shimizu H, Miura T, Ikeuchi T, Takahashi H, Kakita A
    • Organizer
      The 10th Congress of Asia Pacific International Academy of Pathology &
    • Place of Presentation
      Bali (Indonesia)
    • Year and Date
      2017-04-24
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Immunohistochemical features of GGT revealed using a tau oligomer-specific antibody2016

    • Author(s)
      Tanaka H, Toyoshima Y, Tada M, Ikeuchi T, Nishizawa M, Takahashi H, Kakita A
    • Organizer
      11th European Congress of Neuropathology
    • Place of Presentation
      Bordeaux (France)
    • Year and Date
      2016-07-06
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Immunohistochemical features of tauopathies revealed usiing a tau oligomer-specific antibody.2016

    • Author(s)
      Tanaka H, Toyoshima Y, Tada M, Shimizu H, Shiga A, Ikeuchi T, Takahashi H, Kakita A
    • Organizer
      第57回日本神経病理学会総会学術研究会
    • Place of Presentation
      ホテルニューキャッスル (青森県・弘前市)
    • Year and Date
      2016-06-01
    • Related Report
      2016 Annual Research Report
  • [Presentation] Tau oligomer accumulation in patients with globular glial tauopathies -type III2015

    • Author(s)
      Toyoshima Y, Tanaka H, Takeuchi R, Shimizu H, Tada M, Shiga A, Yokota O, Kuroda S, Ikeuchi T, Kakita A, Takahashi H
    • Organizer
      The 26th International Symposium on ALS/MND
    • Place of Presentation
      Orlando, USA
    • Year and Date
      2015-12-10
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Globular glial tauopathy (type II) clinically mimicking ALS2015

    • Author(s)
      Tanaka H, Toyoshima Y, Miura T, Tada M, Shimizu H, Shiga A, Ikeuchi T, Kakita A, Takahashi H
    • Organizer
      The 26th International Symposium on ALS/MND
    • Place of Presentation
      Orlando, USA
    • Year and Date
      2015-12-10
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Globular Glial Mixed Four Repeat Tau and TDP-43 Proteinopathy with Motor Neuron Disease and Frontotemporal Dementia2015

    • Author(s)
      Takeuchi R, Toyoshima Y, Tada M, Shiga A, Miura T, Aoki K, Ikeuchi T, Nishizawa M, Kakita A, Takahashi H
    • Organizer
      The 26th International Symposium on ALS/MND
    • Place of Presentation
      Orlando, USA
    • Year and Date
      2015-12-10
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Globular glial tauopathy:蓄積タウの特徴2015

    • Author(s)
      豊島靖子、竹内亮子、田中英智、他田真理、清水 宏、池内 健、柿田明美、高橋 均
    • Organizer
      第56回日本神経病理学会総会学術研究会
    • Place of Presentation
      九州大学医学部百年講堂、福岡
    • Year and Date
      2015-06-03
    • Related Report
      2015 Research-status Report
  • [Presentation] Astrocyteのタウ病理に注目したPSP関連タウオパチーの連続性について2014

    • Author(s)
      横山裕一、豊島靖子、志賀篤、池内健、長谷川一子、柿田明美、高橋均
    • Organizer
      第55回日本神経病理学会総会学術研究会
    • Place of Presentation
      東京 学術総合センター
    • Year and Date
      2014-06-05 – 2014-06-07
    • Related Report
      2014 Research-status Report
  • [Presentation] 臨床的にALS-Dと診断され、特異な病理組織学的所見を呈したGlobular glial tauopathy の1例2014

    • Author(s)
      竹内亮子、豊島靖子、三浦健、青木賢樹、西澤正豊、柿田明美、高橋均
    • Organizer
      第55回日本神経病理学会総会学術研究会
    • Place of Presentation
      東京 学術総合センター
    • Year and Date
      2014-06-05 – 2014-06-07
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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