Experimental study on functional pathology of dystonia
| Project/Area Number |
26430054
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | The University of Tokushima |
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Principal Investigator |
GOTO Satoshi 徳島大学, 大学院医歯薬学研究部(医学系), 特任教授 (50240916)
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| Co-Investigator(Kenkyū-buntansha) |
梶 龍兒 徳島大学, 大学院医歯薬学研究部(医学系), 教授 (00214304)
森垣 龍馬 徳島大学, 大学院医歯薬学研究部(医学系), 助教 (70710565)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 神経変性疾患 / ジストニア / 神経病理 / 線条体 / ストリオソーム / マトリックス / ドパミン / 機能解剖 / パーキンソニズム |
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| Outline of Final Research Achievements |
In the mammalian striatum that plays a central role in the basal ganglia circuit, there exist two functional subdivisions known as striosome and matrix compartments. During the last 3 years, we found a selective loss of dopamine D1 receptor (D1R)-mediated signals in the striosome compartment in transgenic mouse and human disease models with dystonia. Moreover, we provided the evidence that striatal neurodegeneration causing dystonia might be associated with a lack of striosomal expression of neuroprotective molecules that include neuropeptide Y and postsynaptic density protein 95 (PSD-95). These findings corroborate with the hypothesis that deregulation of D1 signaling in the striosome compartment may underlie the genesis of dystonia.
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Report
(4 results)
Research Products
(19 results)
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[Journal Article] Autopsy case of severe generalized dystonia and static ataxia with marked cerebellar atrophy.2015
Author(s)
Miyamoto R, Sumikura H, Takeuchi T, Sanada M, Fujita K, Kawarai T, Mure H, Morigaki R, Goto S, Murayama S, Izumi Y, Kaji R
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Journal Title
Neurology
Volume: 85
Issue: 17
Pages: 1522-1524
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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